#418: The Science of NAD+: Why Precursors & IVs Fail Without This Step With Courtney Van Bussum

#418: The Science of NAD+: Why Precursors & IVs Fail Without This Step With Courtney Van Bussum

Today, I'm joined by the insightful Courtney Van Bussum, a biomedical engineer and entrepreneur who has become a rising force in longevity science. Courtney shares how growing up in a family of healthcare innovators shaped her journey, and how she pivoted from startup life to tackling age-related challenges—especially when COVID brought her back to her roots and reignited her passion for cellular health. If you want to try Endotelio 1-MNA and save 10% click here and code NAT10 will be entered for you at checkout. Episode Timestamps: Welcome and introduction to Longevity Podcast ... 00:00:00 Challenging beliefs about aging and cellular health ... 00:12:00 Deep dive into NAD+ biochemistry and cellular function ... 00:13:08 NAD+/NADH balance: Why both matter ... 00:15:24 Why NAD+ declines: Not just aging, but increased degradation ...00:18:26 The role of CD38 and NMNT enzymes in NAD metabolism ... 00:20:14 Controversy and confusion: NAD+ precursors (NR, NMN) and IVs ... 00:22:28 Methylation's hidden importance in NAD supplementation ... 00:30:55 Supplementing 1-MNA: Understanding dosages and applications ... 00:50:54 Assessing NAD+ status: Biomarkers and limitations of testing ... 00:53:01 Lifestyle ROI: Sleep, exercise, and circadian rhythm for NAD preservation ... 00:57:14 Ketones: Beyond performance, supporting cellular energy and longevity ... 01:06:03 Future of NAD science: Anticipating new insights and risks ... 01:11:45 Confidence and humility: Advice for navigating the longevity field ... 01:18:52 Our Amazing Sponsors: Qualia Creatine+ by Qualia Life – A clinically formulated blend of two highly bioavailable forms of creatine plus magnesium and electrolytes to support lean muscle, cellular energy, and brain health—especially for women over 40 who naturally produce less with age. Go to qualialife.com/nathalie and use code NATHALIE to save up to 50%, plus an additional 15% off. Complete Liver Complex by LVLUP Health - supports your liver's natural detox pathways so your body can reset after the holidays without suffering. Go to lvluphealth.com and use code NAT for 20% off. Gut Essentials Bundle by Just Thrive Health – This powerhouse duo pairs the only probiotic clinically proven to arrive 100% alive in your gut with science-backed Digestive Bitters to reduce bloat, curb cravings, and support better energy fast. Take the Just Thrive Feel Better Challenge and save 20% at justthrivehealth.com/NAT20 with code NAT20. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode

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A portable AND affordable Red Light & Near Infra Red Light device that can help to heal your injuries, improve your skin, improve your immunity, your gut health and more…Dr Zulia Frost shares all on the new FlexBEAM…

A portable AND affordable Red Light & Near Infra Red Light device that can help to heal your injuries, improve your skin, improve your immunity, your gut health and more…Dr Zulia Frost shares all on the new FlexBEAM…

The FlexBEAM is a tiny and mighty new entry in the photobiomodulation space - the team at Recharge set out to make the safest, most powerful, portable and affordable red light and near infra red light...

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Dr Amber Part 2 on Mitochondrial Energy: MotsC and NAD

Dr Amber Part 2 on Mitochondrial Energy: MotsC and NAD

Please note that this content is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Peptides are for the most part classified...

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Sleep Crown: The Sleep Hack You've Never Heard of that will Supercharge Your Sleep

Sleep Crown: The Sleep Hack You've Never Heard of that will Supercharge Your Sleep

https://www.natniddam.com/ https://www.sleepcrown.com/ Longevity10 saves you 10% off Please note that this content is intended for information purposes only and is not intended to substitute professio...

21 Marras 202043min

Why You Need to Optimize Your Hormones BEFORE anything else with Caleb Greer FNP-C - the best kept secret in functional medicine

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In my opinion Caleb Greer is one of the best kept secrets in Functional Medicine. One of his many superpowers is his ability to take the best from the world of conventional medicine and marry it to Fu...

13 Marras 202045min

Deep Dive into Molecular Hydrogen with Alex Tarnava

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Alex Tarnava of HRW https://drinkhrw.com/ Promo Code: Longevity10 to get 10% off your purchase 0:11 Alex Tarnava and DrinkHRW 1:06 DrinkHRW aims to get messaging right and put forth an honest and accu...

9 Marras 20201h 15min

Cellular Senescence, Why the Goldilocks Approach is the ONLY way to go and SELANK: more than just another brain peptide

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Dr. Seeds is a board-certified orthopedic surgeon and physician specializing in all aspects of sports medicine and total joint treatments. With over 22 years of experience, Dr. Seeds is focused on pro...

2 Marras 20201h 2min

Repair Peptides: TB500 vs Thymosin Beta 4, they are NOT the same

Repair Peptides: TB500 vs Thymosin Beta 4, they are NOT the same

Thymosin Beta 4 and TB500 - are they one and the same? NO! We are BACK!!! In the peptide world these two peptides are often referred to interchangeably....as if they were one. And yet - they are most ...

29 Loka 202034min

Find Out How Fast (or Slowly) You're Aging with Épi-Age & Dr Moshe Szyf

Find Out How Fast (or Slowly) You're Aging with Épi-Age & Dr Moshe Szyf

Dr. Szyf is a pioneer in the field of epigenetics, he holds a PhD from the celebrated Hebrew University, a postdoctoral fellowship in Genetics at Harvard Medical School, a Professorship at McGill Univ...

26 Loka 202055min

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