A cognition engine for science with Allen Stewart

A cognition engine for science with Allen Stewart

Scott Hanselman sits down with Allen Stewart, Partner Director of Software Engineering at Microsoft, to explore how AI agents with persistent memory are transforming scientific research and software engineering. Allen explains how his team built an AI system that learns from every investigation turning a 12-day autonomous drug discovery run into reusable knowledge that makes future research exponentially faster. Instead of starting from scratch each time, the AI inherits hypotheses, methodologies, and findings from previous work, saving hundreds of millions of tokens and weeks of effort.

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The space between the Commits with Zed and DeltaDB's Nathan Sobo

The space between the Commits with Zed and DeltaDB's Nathan Sobo

Scott talks with Nathan Sobo, CEO and co-founder of Zed, about what comes after the traditional code editor. They start with Zed’s vision for a fast, collaborative, AI-native development environment, ...

18 Kesä 33min

Braille Is Freedom with Bristol Braille's Ed Rogers

Braille Is Freedom with Bristol Braille's Ed Rogers

On this episode of Hanselminutes, Scott talks with Ed Rogers of Bristol Braille Technology about the Canute project and the long road toward affordable multiline Braille. Most refreshable Braille disp...

11 Kesä 38min

"Observabilitying" the Future of Software with Charity Majors

"Observabilitying" the Future of Software with Charity Majors

Charity Majors is the co-founder and CTO of Honeycomb.io, where she pioneered the concept of modern observability for distributed systems. Before Honeycomb, she spent years at Parse (acquired by Faceb...

4 Kesä 32min

Cloud Commitments Without the Lock-In with Archera's Aran Khanna

Cloud Commitments Without the Lock-In with Archera's Aran Khanna

Scott talks with Aran Khanna, co-founder and CEO of Archera, about a new category of cloud financial tooling: "Insured Commitments." Instead of locking into 1- or 3-year reserved instance contracts an...

14 Touko 31min

How IBM Z Is Modernizing Mainframes with Skyla Loomis

How IBM Z Is Modernizing Mainframes with Skyla Loomis

Scott talks with Skyla Loomis, General Manager of IBM Z Software, about the ongoing relevance of mainframes in 2026. They discuss the enduring power of mainframes, how generative AI is transforming CO...

7 Touko 31min

Making opinionated AI tooling decisions with Nimbalyst's Greg Hinkle

Making opinionated AI tooling decisions with Nimbalyst's Greg Hinkle

Greg Hinkle, co-founder of Nimbalyst and former VP of Software Engineering at Salesforce, joins Scott to discuss the future of AI-assisted development. They explore the challenges of managing multiple...

30 Huhti 31min

The Joy of Unplugging Cables: Kelly Shortridge on Security Resilience

The Joy of Unplugging Cables: Kelly Shortridge on Security Resilience

Kelly Shortridge, author of "Security Chaos Engineering: Sustaining Resilience in Software and Systems" and CPO at Fastly, joins Scott for an ACM ByteCast joint episode about why security should be de...

23 Huhti 32min

Why Tori Westerhoff says we should talk to strangers

Why Tori Westerhoff says we should talk to strangers

Tori Westerhoff joins Scott to explore the intersection of AI, human psychology, and personal growth. As people increasingly use LLMs for introspection and decision-making, Tori argues that we're miss...

9 Huhti 36min

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