Ozempic Shows Mental Health Benefits but Poses Risks if Stopped, New Research Warns

Recent studies from the past week highlight new insights into Ozempic and similar GLP-1 medications for weight loss. Researchers from the University of Eastern Finland, Karolinska Institutet in Stockholm, and Griffith University in Australia analyzed large-scale data and found that semaglutide, the active ingredient in Ozempic, significantly reduces risks of depression, anxiety, and addiction alongside its weight loss effects. According to their work published in The Lancet Psychiatry, users experienced a 44 percent lower risk of depression and a 38 percent drop in anxiety disorders during treatment periods. Psychiatric hospital visits fell by 42 percent, and substance use disorders decreased by 47 percent compared to times without the medication. The team suggests these benefits may stem from lifestyle changes or direct effects on the brain.

Another study from Washington University School of Medicine, reported by Fox News, warns that stopping GLP-1 drugs like Ozempic quickly erodes heart health gains. Continuous use over three years lowered cardiovascular risk by 18 percent through reductions in cholesterol, blood pressure, inflammation, and insulin resistance. However, quitting for six months raised risk by 4 percent, one year by 14 percent, and two years by 22 percent. Restarting the drugs provided partial protection, only 12 percent, indicating some lasting damage from discontinuation. Lead researcher Ziyad Al-Aly described this as metabolic whiplash, with silent reversals in metabolic health that could lead to heart attacks or strokes.

Oprah Winfrey continues to draw attention for her weight loss transformation using GLP-1 medications. The List reports that recent before-and-after photos from events like the 2025 Tony Awards reveal Ozempic neck, a sagging, crepey skin effect under the jaw due to rapid fat loss outpacing skin adjustment. Winfrey has been seen favoring high-necked outfits to camouflage the loose folds, a common side effect among users.

These developments underscore the dual-edged nature of Ozempic for weight management, offering mental and heart benefits during use but posing challenges with side effects and discontinuation.

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