Season 2 Episode 4: Making it Personal: Targeted Cancer Therapies
Unraveled5 Huhti 2023

Season 2 Episode 4: Making it Personal: Targeted Cancer Therapies

By the early 2000s, researchers at Dana-Farber and elsewhere knew that a certain protein appeared in many tumors taken from lung cancer patients. Based on that data, doctors started treating those patients with a drug that inhibited that protein. Unfortunately, for reasons that weren’t clear at the time, most of the patients didn’t respond — but there was a small percentage of patients, about one out of ten, who did. People called it a "Lazarus-like effect." So how can doctors know which of their patients is Lazarus? How can they know which ones will respond to a drug and which ones won’t? In other words, how can they interpret data so it makes sense? That's the subject of this episode of Unraveled about precision medicine and the EGFR discovery. It's an episode that begins with a riddle and ends with a roadmap.

Tämä jakso on lisätty Podme-palveluun avoimen RSS-syötteen kautta eikä se ole Podmen omaa tuotantoa. Siksi jakso saattaa sisältää mainontaa.

Jaksot(14)

Season 2 Episode 6: Big Data, AI, and Cancer Research

Season 2 Episode 6: Big Data, AI, and Cancer Research

As our universe of knowledge expands, sometimes incrementally and more often, exponentially, its new dimensions create new challenges. The more we know, the better our tools are, the more choices we h...

17 Touko 202328min

Season 2 Episode 5: With a Little Help From My Friends: Combination Immunotherapy

Season 2 Episode 5: With a Little Help From My Friends: Combination Immunotherapy

If there is such a thing as a holy grail in cancer research, a secret spell or golden ring that can ward off any and all forms of the disease, it probably lives somewhere in the realm of immunotherapy...

26 Huhti 202332min

Season 2 Episode 3: Stop the Division: CDK-4/6 Inhibitors and the Cell Cycle

Season 2 Episode 3: Stop the Division: CDK-4/6 Inhibitors and the Cell Cycle

Cancer is often a problem of cell division; cancer cells keep doubling and doubling, faster and faster. Eventually, they crowd out the healthy cells we need to survive. So researchers proposed a quest...

15 Maalis 202326min

Season 2 Episode 2: Thalidomide and its Second Act in Multiple Myeloma

Season 2 Episode 2: Thalidomide and its Second Act in Multiple Myeloma

Momentum isn't always one way. And it's not always constant. Sometimes it shoves you sideways, sometimes it stops you in your tracks. And sometimes only sometimes, it drives you to write one of the mo...

22 Helmi 202328min

Season 2 Episode 1 BCL-2 Inhibitors: Driving Cells to Destruction

Season 2 Episode 1 BCL-2 Inhibitors: Driving Cells to Destruction

The story begins decades ago with a man named Stanley Korsmeyer, who led the molecular oncology program at Dana-Farber from 1998 until his death in 2005. He discovered that B-cell cancers like CLL ove...

1 Helmi 202330min

Season 2 Trailer

Season 2 Trailer

In season 2 of Unraveled, we explore the theme of momentum. The momentum that takes therapies from test bench to bedside, and then back to test bench for fine tuning. The momentum provided by research...

27 Tammi 20232min

Episode 6: Dana-Farber in the Time of COVID

Episode 6: Dana-Farber in the Time of COVID

A beauty… that in some cases becomes tragic. It’s not the way most people would describe a virus. In the simplest of terms, a virus is a snippet of genetic code. It can’t reproduce on its own. So, in ...

4 Loka 202131min

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