Founder vs. Cancer: A Real-Life Hail Mary

Founder vs. Cancer: A Real-Life Hail Mary

After watching Project Hail Mary, Cal sees more than a sci-fi story about saving the stars—he sees a blueprint for how humans might survive the age of AI. That insight leads him to a real-life story even more extraordinary. When tech founder Sid Sijbrandij is diagnosed with a rare, aggressive cancer, the traditional medical system eventually runs out of answers. Most people would accept that outcome. Sid does the opposite. He treats his own disease like an open- source problem—gathering data, building a team, and chasing solutions across the globe with the same mindset that helped build GitLab into a billion-dollar company. With the help of AI, Cal translates this complex scientific journey into a human story anyone can follow. One that's filled with pancakes, partnerships, love, and a radical idea: What if the future of survival—against disease, against uncertainty, against AI itself—belongs to those who adapt fastest? This episode is about more than cancer. It's about how humans fight back.

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Building New Muscles With AI

Building New Muscles With AI

Cal goes to the heartland to talk with a man who's spent decades teaching kids how to build strength the right way for a conversation on how his training approach overlaps with AI. Turns out, Michael ...

8 Syys 51min

Tower 2 Fell On His Head: 25 Years Later

Tower 2 Fell On His Head: 25 Years Later

As the 25th anniversary of 9/11 approaches, Cal replays one of the most powerful conversations in Big Questions' archive: his interview with Michael Wright, a survivor who was buried alive when Tower ...

1 Syys 1h 12min

The Future, Interrupted by a Tornado

The Future, Interrupted by a Tornado

Mike Bechtel doesn't just study the future — he makes a living seeing it before the rest of us. As a historian, futurist, and professor at the University of Notre Dame, he spends his days tracing the ...

25 Elo 1h 2min

Seeing the Path

Seeing the Path

Lachi is a blind musician who has produced GRAMMY nominated projects. She's also a GRAMMY trustee. And the voice behind Diseducation — a song built on the idea that the world needs a new way of thinki...

18 Elo 58min

From A Chicken To Infinite

From A Chicken To Infinite

"If you want to know what life's like when you're not the apex of intelligence, ask a chicken."That's the line that Geoffrey Hinton, the Nobel Prize-winning "Godfather of AI" dropped on Steven Bartlet...

11 Elo 32min

Be Happy, Kevin's Here!

Be Happy, Kevin's Here!

Everybody's telling you that AI is coming for your job. Kevin Surace is here to tell you what they're not telling you. Kevin's the father of the artificial assistant. A CNBC Top Innovator of the Decad...

4 Elo 35min

Can't Automate What She Did Next

Can't Automate What She Did Next

A patient kept showing up in the Emergency Room. Most insurance reps would approve or decline each claim and move on. One customer service representative at Devoted Health called to ask the patient wh...

28 Heinä 44min

Decoding The World

Decoding The World

Cal has a suspicion that the little-known K Economy explains more about where the world is headed than most of what you hear on the news. So he reaches out to one of the world's most masterful interpr...

21 Heinä 44min

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