#544: Wheel Next + Packaging PEPs

#544: Wheel Next + Packaging PEPs

When you pip install a package with compiled code, the wheel you get is built for CPU features from 2009. Want newer optimizations like AVX2? Your installer has no way to ask for them. GPU support? You're on your own configuring special index URLs. The result is fat binaries, nearly gigabyte-sized wheels, and install pages that read like puzzle books. A coalition from NVIDIA, Astral, and QuanSight has been working on Wheel Next: A set of PEPs that let packages declare what hardware they need and let installers like uv pick the right build automatically. Just uv pip install torch and it works. I sit down with Jonathan Dekhtiar from NVIDIA, Ralf Gommers from Quansight and the NumPy and SciPy teams, and Charlie Marsh, founder of Astral and creator of uv, to dig into all of it.

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#556: Updates on Django's Async Story

#556: Updates on Django's Async Story

For years, "Django and async" came with an asterisk. The docs themselves warned you off it. Scary performance notes, a story that felt half-finished. Well, that story just got rewritten, literally, an...

26 Heinä 0s

#555: Marimo Pair - A Canvas for Agent + Developers Collaboration

#555: Marimo Pair - A Canvas for Agent + Developers Collaboration

Coding agents have gotten really good at one kind of work. You scope a feature, edit some files, run the tests, ship it. It all happens on disk. But that is not how data work feels. You load something...

13 Heinä 1h 4min

#554: Trustworthy AI in Healthcare and Longevity

#554: Trustworthy AI in Healthcare and Longevity

You ask an AI a question and it answers with total confidence. Most of the time, a confidently wrong answer is just an annoyance. But what if the question is medical, and there's a real patient on the...

10 Heinä 1h

#553: All of our tools

#553: All of our tools

This episode is a fun crossover from our Python news and tips podcast, Python Bytes. We have had some big changes over there. Brian Okken has moved on and Calvin Hendryx-Parker has joined the show as ...

26 Kesä 55min

#552: Astral joins OpenAI

#552: Astral joins OpenAI

OpenAI just acquired Astral, the company behind uv, Ruff, and ty. And if your first thought was "wait, is uv toast?", you are not alone. But here's the twist Charlie Marsh shared with me: he thinks th...

17 Kesä 1h 5min

#551: Stroll Down Startup Lane - 2026

#551: Stroll Down Startup Lane - 2026

If you've ever been to PyCon, you know one of the best parts of the expo hall is Startup Row, a stretch of booths where early-stage companies built on Python show off what they're creating. But only a...

11 Kesä 1h 48min

#550: AI Contributions and Maintainer Load in Open Source

#550: AI Contributions and Maintainer Load in Open Source

You wake up, brew the coffee, open GitHub, and there it is. Another pull request on your open source project. Thirteen thousand lines added. No issue filed first. No discussion. Just "here, please rev...

30 Touko 1h 2min

#549: Great Docs

#549: Great Docs

Your documentation has two audiences now - humans reading the rendered HTML, and AI agents trying to make sense of your library. Rich Iannone and Michael Chow from Posit are back on Talk Python with a...

25 Touko 1h 7min