Drugs (Sometimes) Work: "Do ACE inhibitors treat Diabetes?"

Drugs (Sometimes) Work: "Do ACE inhibitors treat Diabetes?"

Before we ask a patient to take any drug we should be confident that the benefits outweigh the risks. This involves considerations like duration of therapy and whether the drug is being used to treat a disease versus prevent it. But even more important is an understanding of how the pharmacology of the drug matches up to the pathophysiology of the disease. The better we understand both, the better we'll be at deciding when to use any drug for any disease.

In todays episode we apply these tenets of drug therapy to a common question, "does my patient with diabetes need to be on an ACEi or ARB?" To answer that question, we'll discuss the merits of drugs for disease prevention versus disease treatment. The use of risk factors for disease may or may not be sufficient to justify drug therapy. An LDL cholesterol of 220 is sufficient to initiate cholesterol lowering therapy. But is diabetes a sufficient reason to initiate an ACEi or ARB? We'll figure that out....and whether or not the answer surprises you, we'll learn things along the way that will be useful in virtually all settings of applied pharmacotherapy.

Jaksot(15)

Vitamania, Part 2

Vitamania, Part 2

In this second part of the 2-part episode "Vitamania," we dig in to the clinical trial data behind vitamins as dietary supplements. In Part 1 of this episode, we met a patient with Scurvy....and said ...

12 Touko 202222min

Vitamania, Part 1

Vitamania, Part 1

Vitamins are widely used in the U.S., to the tune of between $15-20 billion dollars per year. But what are vitamins and what do they do? How are they regulated by the FDA and does the clinical trial d...

10 Touko 202216min

Medicating the Failing Heart, Part 3 of 3: The finale

Medicating the Failing Heart, Part 3 of 3: The finale

As we finish up we focus on the contemporary management of systolic heart failure or so called heart failure with reduced ejection fraction. Our focus in this episode is on RAAS blockade which include...

18 Touko 202122min

Medicating the Failing Heart; Part 2: The difference between a drug and not a drug is dose

Medicating the Failing Heart; Part 2: The difference between a drug and not a drug is dose

In this continuation of "Medicating the Failing Heart" we pick up the theme of systolic heart failure and how good beta blockers are or aren't compared to our newest agent for systolic heart failure -...

12 Touko 202116min

Episode 9, Medicating the failing heart, Part 1

Episode 9, Medicating the failing heart, Part 1

When it comes to treating symptomatic heart failure, many things have changed but many have not. Some things that haven't changed maybe should change - that depends on who you listen to. In this multi...

7 Touko 202114min

"Ceph-a-Something" Part 2: pesky PK

"Ceph-a-Something" Part 2: pesky PK

The cephalosporin antibiotics are a confusing class of medications. We talk about them in "generations" like a pharmacologic family tree. And while there is a general rule regarding which bugs are cov...

23 Huhti 202114min

"Ceph-a-Something" Part 1: Genealogy

"Ceph-a-Something" Part 1: Genealogy

The cephalosporin antibiotics are a confusing class of medications. We talk about them in "generations" like a pharmacologic family tree. And while there is a general rule regarding which bugs are cov...

23 Huhti 202111min

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