Zombie Cells in the Wound: How Senescent Fibroblasts Sabotage Diabetic Ulcers

Zombie Cells in the Wound: How Senescent Fibroblasts Sabotage Diabetic Ulcers

Dr. G examines how normal fibroblasts drive tissue repair and how, in diabetic foot ulcers, they can become senescent “zombie” cells that stop dividing, secrete inflammatory SASP factors, and degrade the wound environment.

The episode covers triggers (hyperglycemia, oxidative stress, ischemia, infection), clinical signs and biomarkers of senescence, the vicious cycle with biofilm, and emerging approaches—including senolytics, targeted dressings, and debridement—to reduce senescent burden and improve healing.

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Jaksot(366)

“I Have a Diabetic Foot Ulcer… But I Don’t Have Insurance. Now What?”

“I Have a Diabetic Foot Ulcer… But I Don’t Have Insurance. Now What?”

This episode explains what to do if you have a diabetic foot ulcer and no health insurance, stressing that you should not ignore the wound or try to self-treat. It covers signs of infection, the need ...

21 Elo 17min

SMAPs: Rethinking Antimicrobials for Diabetic Foot Care

SMAPs: Rethinking Antimicrobials for Diabetic Foot Care

This episode explores SMAPs — synthetic mimics of antimicrobial peptides — and how they use membrane-targeting chemistry to kill bacteria differently from conventional antibiotics. It covers the scien...

19 Elo 21min

LIMBWatch Series: Dr. Shilpa Rajan Mulki- Look at Your Feet Before You Sleep: Saving Limbs in Resource-Limited Settings

LIMBWatch Series: Dr. Shilpa Rajan Mulki- Look at Your Feet Before You Sleep: Saving Limbs in Resource-Limited Settings

🎙️ Diabetic Foot Files: Limb Watch with Dr. Shilpa Rajan Mulki What if some amputations could be prevented simply by recognizing the warning signs sooner? In this episode of Diabetic Foot Files: Limb...

17 Elo 48min

The Toe That Killed Jack Daniel: The Untold Medical Story

The Toe That Killed Jack Daniel: The Untold Medical Story

A man who built a global whiskey empire may have been felled not by drink or duel but by a small foot injury that turned infected. This episode examines the legend of Jack Daniel’s toe, the historical...

16 Elo 36min

Understanding Undermining- Unseen, unexpected and unforgiving : The Truth Behind “Doctor Made My Wound Bigger” — Understanding Undermining

Understanding Undermining- Unseen, unexpected and unforgiving : The Truth Behind “Doctor Made My Wound Bigger” — Understanding Undermining

This episode explains undermining in diabetic foot ulcers—how tissue destruction can extend beneath intact skin, why wounds may appear larger after debridement, and what that means for healing. We cov...

15 Elo 19min

Teeth in the Tide- When the Ocean Bites: Barracuda Strike and Diabetic Foot Danger

Teeth in the Tide- When the Ocean Bites: Barracuda Strike and Diabetic Foot Danger

In this episode Dr. G recounts a surprising barracuda bite that exposes the challenges of marine injuries, especially for people with diabetes. The episode explains how sharp lacerations, contaminatio...

15 Elo 22min

Forgotten Infection Friday- Madura Foot: The Silent, Years-Long Infection Hiding in Plain Sight

Forgotten Infection Friday- Madura Foot: The Silent, Years-Long Infection Hiding in Plain Sight

This episode reviews Madura foot (mycetoma), a chronic implantation infection characterized by long-standing swelling, multiple sinus tracts, and visible ‘‘grains.’p> There are two main types — eumyce...

15 Elo 33min

LIMBWatch Series: Dr. Andrew JM Boulton, MD, DSc (Hon), FACP, FICP, FRCP-The Man Who Changed Diabetic Foot Care Dr. Andrew Boulton on Neuropathy, Prevention & Saving Limbs Worldwide

LIMBWatch Series: Dr. Andrew JM Boulton, MD, DSc (Hon), FACP, FICP, FRCP-The Man Who Changed Diabetic Foot Care Dr. Andrew Boulton on Neuropathy, Prevention & Saving Limbs Worldwide

Welcome to LIMBWatch — the global movement dedicated to protecting limbs, preventing amputations, and transforming the future of diabetic foot care. In this landmark episode, we welcome one of the wor...

10 Elo 46min

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