Semaglutide Steps In: New Hope for PAD Patients

Semaglutide Steps In: New Hope for PAD Patients

This episode explores new randomized evidence that semaglutide, a GLP-1 receptor agonist used for diabetes and weight loss, can improve walking distance and quality of life for people with type 2 diabetes and symptomatic peripheral arterial disease (PAD).

The landmark STRID trial showed median gains of about 26 meters (mean ~40 m) in walking distance over a year, along with better pain scores and daily function. Large real-world studies also suggest fewer PAD-related hospitalizations and amputations.

Benefits likely come from multiple effects: weight loss and improved glucose control, anti-inflammatory actions, better endothelial function and muscle metabolism, all combining to improve perfusion and exercise capacity.

Semaglutide is an adjunct to standard PAD care (exercise, smoking cessation, statins, antiplatelets, revascularization when needed). Common side effects include GI symptoms; monitor eye health, pancreatitis risk, and avoid use in patients with MEN2 or medullary thyroid cancer history.

Tämä jakso on lisätty Podme-palveluun avoimen RSS-syötteen kautta eikä se ole Podmen omaa tuotantoa. Siksi jakso saattaa sisältää mainontaa.

Jaksot(322)

LIMBWatch Series: Riley Csernica, VP of Product Development at DARCO International: From Napkin to Norm: GO Line ™ Unveiled & The DARCO Story Behind Modern Offloading

LIMBWatch Series: Riley Csernica, VP of Product Development at DARCO International: From Napkin to Norm: GO Line ™ Unveiled & The DARCO Story Behind Modern Offloading

On this episode of Limb Watch, Riley Csernica, VP of Product Development at DARCO International, recounts the company’s origin and explains the GO Line ™ innovations — including AirCore™ and PowerPods...

16 Kesä 24min

The Wound That Hated Debridement: Recognizing Pathergy and Great mimics of Diabetic Foot Infection

The Wound That Hated Debridement: Recognizing Pathergy and Great mimics of Diabetic Foot Infection

A patient with a presumed infected diabetic foot ulcer worsens after debridement and escalating antibiotics. This episode explores pathergy — an exaggerated inflammatory response to minor trauma that ...

15 Kesä 20min

Escaping Plato’s Cave: Amputation Illusion- how healthcare learned to accept preventable limb loss

Escaping Plato’s Cave: Amputation Illusion- how healthcare learned to accept preventable limb loss

In this episode of Diabetic Foot Files Dr. G uses Plato's allegory of the cave to reveal how long‑standing assumptions and systemic failures—not just biology—drive many diabetes‑related amputations. H...

14 Kesä 26min

From seizures to Granulation Nation: The Unexpected Story of Phenytoin in Wound Healing

From seizures to Granulation Nation: The Unexpected Story of Phenytoin in Wound Healing

This episode traces how phenytoin — an anticonvulsant known for causing gingival overgrowth — was repurposed into a topical therapy for chronic wounds. It outlines the drug’s mechanisms in wounds: act...

13 Kesä 24min

Forgotten Infection Friday- Buruli Ulcer vs Diabetic Foot: Lessons from a Painless Wound

Forgotten Infection Friday- Buruli Ulcer vs Diabetic Foot: Lessons from a Painless Wound

This episode explores the rare Buruli (Buruli) ulcer caused by Mycobacterium ulcerans and its toxin mycolactone, which destroys tissue, suppresses immune signaling, and reduces pain, leading to delaye...

12 Kesä 25min

Why we use Saline vs. Sterile Water vs. Tap Water vs Seawater- Not all water is equal

Why we use Saline vs. Sterile Water vs. Tap Water vs Seawater- Not all water is equal

In this episode Dr. G explains why 0.9% sterile saline is the preferred when using to cleanse for diabetic foot ulcers, diving into osmosis, isotonicity, and how saline preserves cell function while...

11 Kesä 29min

Wound Intelligence Wednesday: Atraumatic Dressings for Diabetic Limbs

Wound Intelligence Wednesday: Atraumatic Dressings for Diabetic Limbs

This episode explains traumatic dressing selection for diabetic wounds, emphasizing atraumatic (especially silicone-based) dressings that protect fragile peri-wound skin, preserve keratinocytes and ca...

10 Kesä 27min

Beyond Closure/ Post Healing Maintenance : Inside the Long Remodeling Phase of Wound Healing

Beyond Closure/ Post Healing Maintenance : Inside the Long Remodeling Phase of Wound Healing

Dr. G explains why skin closure in diabetic foot ulcers is a transition, not a cure: the remodeling phase can last months to years, leaving the scar biologically weaker and at high risk of recurrence....

9 Kesä 31min

Suosittua kategoriassa Koulutus

rss-murhan-anatomia
psykopodiaa-podcast
rss-valo-minussa-2
voi-hyvin-meditaatiot-2
rss-narsisti
adhd-podi
psykologia
rss-koira-haudattuna
kesken
rss-duodecim-lehti
salainen-paivakirja
rss-hereilla
leikitaanko-laakaria
rss-liian-kuuma-peruna
rss-suomen-aa-podcast
rss-monarch-talk-with-alexandra-alexis
rss-luonnollinen-synnytys-podcast
rss-niinku-asia-on
dear-ladies
rss-arkea-ja-aurinkoa-podcast-espanjasta