234 | Tobias Warnecke on Cellular Structure and Evolution

234 | Tobias Warnecke on Cellular Structure and Evolution

Eukaryotic cells manage to pull off a number of remarkable feats. One is packing quite a long DNA molecule, with potentially billions of base pairs, into a tiny central nucleus. A key role is played by histones, proteins that provide scaffolding for DNA to wrap around. Histones also appear in archaea (one of the other domains of life), but until recently there wasn't evidence for them in bacteria (the final of the three domains). Todays guest, Tobias Warnecke, is an author on a recent paper that claims to provide such evidence. We discuss this new result, as well as background questions of how cells evolved and what their current structure can teach us about their histories.

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Tobias Warnecke received his Ph.D. in biology from the University of Bath. He is currently a Programme Leader and MRC Investigator at the London Institute of Medical Sciences. He is a co-author on A. Hochner et al. (2023), "Histone-Organized Chromatin in Bacteria."


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Jaksot(411)

196 | Judea Pearl on Cause and Effect

196 | Judea Pearl on Cause and Effect

To say that event A causes event B is to not only make a claim about our actual world, but about other possible worlds — in worlds where A didn’t happen but everything else was the same, B would not h...

9 Touko 20221h 16min

195 | Richard Dawkins on Flight and Other Evolutionary Achievements

195 | Richard Dawkins on Flight and Other Evolutionary Achievements

Evolution has equipped species with a variety of ways to travel through the air — flapping, gliding, floating, not to mention jumping really high. But it hasn’t invented jet engines. What are the diff...

2 Touko 20221h 18min

194 | Frans de Waal on Culture and Gender in Primates

194 | Frans de Waal on Culture and Gender in Primates

Humans are related to all other species here on Earth, but some are closer relatives than others. Primates, a group that includes apes, monkeys, lemurs, and others besides ourselves, are our closest r...

25 Huhti 20221h 8min

193 | Daniels on Everything, Everywhere, All at Once

193 | Daniels on Everything, Everywhere, All at Once

Every time we make an important decision, it’s hard not to wonder how things would have turned out had we chosen differently. The set of all those hypothetical lives is a kind of “multiverse” — not on...

18 Huhti 20221h 8min

AMA | April 2022

AMA | April 2022

Welcome to the April 2022 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). I take the large number of quest...

14 Huhti 20223h 27min

192 | Nicole Yunger Halpern on Quantum Steampunk Thermodynamics

192 | Nicole Yunger Halpern on Quantum Steampunk Thermodynamics

Randomness and probability are central to modern physics. In statistical mechanics this is because we don’t know everything about the distribution of atoms and molecules in a fluid, so we consider a p...

11 Huhti 20221h 17min

191 | Jane McGonigal on How to Imagine the Future

191 | Jane McGonigal on How to Imagine the Future

The future grows out of the present, but it manages to consistently surprise us. How can we get better at anticipating and preparing for what the future can be like? Jane McGonigal started out as a ga...

4 Huhti 20221h 21min

190 | Lea Goentoro on Regrowing Limbs

190 | Lea Goentoro on Regrowing Limbs

Biological organisms are pretty good at healing themselves, but their abilities fall short in crucial ways. Planaria can be cut into pieces, and each piece will regrow into an entire organism; but for...

28 Maalis 20221h 3min

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