234 | Tobias Warnecke on Cellular Structure and Evolution

234 | Tobias Warnecke on Cellular Structure and Evolution

Eukaryotic cells manage to pull off a number of remarkable feats. One is packing quite a long DNA molecule, with potentially billions of base pairs, into a tiny central nucleus. A key role is played by histones, proteins that provide scaffolding for DNA to wrap around. Histones also appear in archaea (one of the other domains of life), but until recently there wasn't evidence for them in bacteria (the final of the three domains). Todays guest, Tobias Warnecke, is an author on a recent paper that claims to provide such evidence. We discuss this new result, as well as background questions of how cells evolved and what their current structure can teach us about their histories.

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Tobias Warnecke received his Ph.D. in biology from the University of Bath. He is currently a Programme Leader and MRC Investigator at the London Institute of Medical Sciences. He is a co-author on A. Hochner et al. (2023), "Histone-Organized Chromatin in Bacteria."


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183 | Michael Dine on Supersymmetry, Anthropics, and the Future of Particle Physics

183 | Michael Dine on Supersymmetry, Anthropics, and the Future of Particle Physics

Modern particle physics is a victim of its own success. We have extremely good theories — so good that it’s hard to know exactly how to move beyond them, since they agree with all the experiments. Yet...

7 Helmi 20221h 39min

182 | Sally Haslanger on Social Construction and Critical Theory

182 | Sally Haslanger on Social Construction and Critical Theory

Reality is just out there — but how we perceive reality and talk about it depends on choices we human beings make. We decide (consciously or not) to conceptualize the world in certain ways, whether it...

31 Tammi 20221h 37min

181 | Peter Dodds on Quantifying the Shape of Stories

181 | Peter Dodds on Quantifying the Shape of Stories

A good story takes you on an emotional journey, with ups and downs along the way. Thanks to science, we can quantify that. Peter Dodds works on understanding the structure of stories and other strings...

24 Tammi 20221h 16min

180 | Camilla Pang on Instructions for Being Human

180 | Camilla Pang on Instructions for Being Human

Being a human is tricky. There are any number of unwritten rules and social cues that we have to learn as we go, but that we ultimately learn to take for granted. Camilla Pang, who was diagnosed with ...

17 Tammi 20221h 3min

179 | David Reich on Genetics and Ancient Humanity

179 | David Reich on Genetics and Ancient Humanity

Human beings like to divide themselves into groups, and then cooperate, socialize, and reproduce with members of their own group. But they’re not very absolutist about it; groups tend to gradually (or...

10 Tammi 20221h 13min

178 | Jody Azzouni on What Is and Isn't Real

178 | Jody Azzouni on What Is and Isn't Real

Are numbers real? What does that even mean? You can’t kick a number. But you can talk about numbers in useful ways, and we use numbers to talk about the real world. There’s surely a kind of reality th...

3 Tammi 20221h 14min

Holiday Message 2021 | On Disciplines & Cocktails

Holiday Message 2021 | On Disciplines & Cocktails

As each December comes to a close, we wrap up another year of podcasts with the Mindscape Holiday Message. Nothing too profound, just some thoughts that wouldn’t fit easily into a regular podcast. Thi...

20 Joulu 202159min

AMA | December 2021

AMA | December 2021

Welcome to the December 2021 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). I take the large number of qu...

15 Joulu 20213h 37min

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