234 | Tobias Warnecke on Cellular Structure and Evolution

234 | Tobias Warnecke on Cellular Structure and Evolution

Eukaryotic cells manage to pull off a number of remarkable feats. One is packing quite a long DNA molecule, with potentially billions of base pairs, into a tiny central nucleus. A key role is played by histones, proteins that provide scaffolding for DNA to wrap around. Histones also appear in archaea (one of the other domains of life), but until recently there wasn't evidence for them in bacteria (the final of the three domains). Todays guest, Tobias Warnecke, is an author on a recent paper that claims to provide such evidence. We discuss this new result, as well as background questions of how cells evolved and what their current structure can teach us about their histories.

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Tobias Warnecke received his Ph.D. in biology from the University of Bath. He is currently a Programme Leader and MRC Investigator at the London Institute of Medical Sciences. He is a co-author on A. Hochner et al. (2023), "Histone-Organized Chromatin in Bacteria."


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342 | Rachell Powell on Evolutionary Convergence, Morality, and Mind

342 | Rachell Powell on Evolutionary Convergence, Morality, and Mind

Evolution with natural selection involves an intricate mix of the random and the driven. Mutations are essentially random, while selection pressures work to prefer certain outcomes over others. There ...

26 Tammi 1h 37min

341 | Stewart Brand on Maintenance as an Organizing Principle

341 | Stewart Brand on Maintenance as an Organizing Principle

"Things fall apart; the centre cannot hold," wrote W.B. Yeats. I don't know about the centre, but the tendency of things to fall apart is pretty universal, ultimately due to the Second Law of Thermody...

19 Tammi 1h 12min

340 | Rebecca Newberger Goldstein on What Matters and Why It Matters

340 | Rebecca Newberger Goldstein on What Matters and Why It Matters

At any given moment, an uncountable number of events are happening, but only some of them matter to us. What does it mean for something to matter, and more importantly, what does it mean for us to mat...

12 Tammi 1h 18min

339 | Ned Block on Whether Consciousness Requires Biology

339 | Ned Block on Whether Consciousness Requires Biology

It's become increasingly clear that the Turing Test -- determining whether human interlocutors can tell whether a conversation is being carried out by a human or a machine -- is not a good way to thin...

5 Tammi 1h 11min

Holiday Message 2025 | The Romance of the University

Holiday Message 2025 | The Romance of the University

Time for the holiday message! Rounding off the year with a brief and casual reflection on some issue that doesn't quite rise to the level of a full solo podcast. And hopefully something uplifting. Thi...

22 Joulu 202542min

AMA | December 2025

AMA | December 2025

Welcome to the December 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Pa...

15 Joulu 20253h 36min

338 | Ryan Patterson on the Physics of Neutrinos

338 | Ryan Patterson on the Physics of Neutrinos

The story goes that Wolfgang Pauli, who first proposed the existence of neutrinos, was embarrassed to have done so, as it was considered uncouth to hypothesize new particles that could not be detected...

8 Joulu 20251h 26min

337 | Kevin Zollman on Game Theory, Signals, and Meaning

337 | Kevin Zollman on Game Theory, Signals, and Meaning

Game theory is a way of quantitatively describing what happens any time one thing interacts with another thing, when both things have goals and potential rewards. That's a pretty broad class of intere...

1 Joulu 20251h 17min

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