T-Cell Memory and Metabolic Response to Weight Cycling, Gut-Derived FGF15 Modulating Lean Mass, Bone, and Bile Acid Responses to Weight Loss, plus "Sweet Talk" with Myers, past recipient of the Outstanding Scientific Achievement Award

Welcome to the June 2026 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the June 2026 issue of Diabetes.

7:00 To discuss this issue's Paper of the Month, our hosts speak with Alyssa Hasty, PhD, Vice Provost and Senior Associate Dean of Faculty Affairs at UT Southwestern in Dallas, and Jamie Garcia, PhD, Associate Director for Scientific Partnerships and Engagement at Jane Coffin Childs Memorial Fund for Medical Research. Their article, "Interrupting T-Cell Memory Ameliorates Exaggerated Metabolic Response to Weight Cycling," is available for free at doi.org/10.2337/db25-0605.

27:35 Next, Darleen is joined by Randy J. Seeley, PhD, Henry King Ransom Professor of Surgery and Professor of Internal Medicine and Nutritional Sciences at the University of Michigan School of Medicine, as well as Nadejda Bozadjieva Kramer, PhD, Assistant Professor of Surgery at the University of Michigan School of Medicine. Their article, "Gut-Derived FGF15 Modulates Lean Mass, Bone, and Bile Acid Responses to Weight Loss," is available for free at doi.org/10.2337/db25-0466.

57:40 In the latest edition of "Sweet Talk," our hosts speak with Martin Myers, MD, PhD, Marilyn H Vincent Professor of Diabetes Research at the University of Michigan, Director of the Elizabeth Caswell Diabetes Institute, and recipient of the 2010 Outstanding Scientific Achievement Award from the American Diabetes Association. They talk about his work in leptin receptor signaling and the way brain circuitry works alongside GLP-1 based drugs to induce weight loss.

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!