Zaynich: A New Weapon Against MDR Gram-Negatives

Zaynich: A New Weapon Against MDR Gram-Negatives

In this episode of Diabetic Foot Files, Dr. G explores Zaynich (cefepime + ZD-bactam), a newly FDA-approved IV antibiotic designed to overcome multi-drug resistant gram-negative infections. He explains the drug's dual-target mechanism, its potential role in limb salvage for severe diabetic foot infections, common side effects, dosing, current FDA indications, and when to involve infectious disease specialists.

Listeners will learn why this combination may be a game-changer for difficult-to-treat infections, the importance of antibiotic stewardship, and practical considerations for use in wound care and limb salvage scenarios.

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LIMBWatch Series: Dr. Shilpa Rajan Mulki- Look at Your Feet Before You Sleep: Saving Limbs in Resource-Limited Settings

LIMBWatch Series: Dr. Shilpa Rajan Mulki- Look at Your Feet Before You Sleep: Saving Limbs in Resource-Limited Settings

🎙️ Diabetic Foot Files: Limb Watch with Dr. Shilpa Rajan Mulki What if some amputations could be prevented simply by recognizing the warning signs sooner? In this episode of Diabetic Foot Files: Limb...

17 Elo 48min

The Toe That Killed Jack Daniel: The Untold Medical Story

The Toe That Killed Jack Daniel: The Untold Medical Story

A man who built a global whiskey empire may have been felled not by drink or duel but by a small foot injury that turned infected. This episode examines the legend of Jack Daniel’s toe, the historical...

16 Elo 36min

Understanding Undermining- Unseen, unexpected and unforgiving : The Truth Behind “Doctor Made My Wound Bigger” — Understanding Undermining

Understanding Undermining- Unseen, unexpected and unforgiving : The Truth Behind “Doctor Made My Wound Bigger” — Understanding Undermining

This episode explains undermining in diabetic foot ulcers—how tissue destruction can extend beneath intact skin, why wounds may appear larger after debridement, and what that means for healing. We cov...

15 Elo 19min

Teeth in the Tide- When the Ocean Bites: Barracuda Strike and Diabetic Foot Danger

Teeth in the Tide- When the Ocean Bites: Barracuda Strike and Diabetic Foot Danger

In this episode Dr. G recounts a surprising barracuda bite that exposes the challenges of marine injuries, especially for people with diabetes. The episode explains how sharp lacerations, contaminatio...

15 Elo 22min

Forgotten Infection Friday- Madura Foot: The Silent, Years-Long Infection Hiding in Plain Sight

Forgotten Infection Friday- Madura Foot: The Silent, Years-Long Infection Hiding in Plain Sight

This episode reviews Madura foot (mycetoma), a chronic implantation infection characterized by long-standing swelling, multiple sinus tracts, and visible ‘‘grains.’p> There are two main types — eumyce...

15 Elo 33min

LIMBWatch Series: Dr. Andrew JM Boulton, MD, DSc (Hon), FACP, FICP, FRCP-The Man Who Changed Diabetic Foot Care Dr. Andrew Boulton on Neuropathy, Prevention & Saving Limbs Worldwide

LIMBWatch Series: Dr. Andrew JM Boulton, MD, DSc (Hon), FACP, FICP, FRCP-The Man Who Changed Diabetic Foot Care Dr. Andrew Boulton on Neuropathy, Prevention & Saving Limbs Worldwide

Welcome to LIMBWatch — the global movement dedicated to protecting limbs, preventing amputations, and transforming the future of diabetic foot care. In this landmark episode, we welcome one of the wor...

10 Elo 46min

Antimicrobial ≠ Antibiotic: Antimicrobial Doesn’t Mean Antibiotic

Antimicrobial ≠ Antibiotic: Antimicrobial Doesn’t Mean Antibiotic

This episode clarifies the difference between antimicrobials (agents that act against a range of microorganisms) and antibiotics (drugs that specifically target bacteria), and explains related terms l...

9 Elo 22min

Why Your Healed Wound Still Feels Tight — What Causes Tight Skin After Diabetic Foot Wounds

Why Your Healed Wound Still Feels Tight — What Causes Tight Skin After Diabetic Foot Wounds

This episode explains why healed wounds can feel tight, covering the stages of wound healing, the role of myofibroblasts and alpha-SMA in wound contraction, and how scar tissue differs from normal ski...

8 Elo 21min

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