Milestones in Pediatric Nutrition - DOHaD (Developmental Origins): The lifelong imprint of early nutrition - Episode 6

Milestones in Pediatric Nutrition - DOHaD (Developmental Origins): The lifelong imprint of early nutrition - Episode 6

In this episode of Milestones in Pediatric Nutrition, Professor Andrew Prentice interviews Professor Chittaranjan Yajnik about the Developmental Origins of Health and Disease (DOHaD) theory. Professor Yajnik traces its origins to David Barker's "Fetal Origins of Adult Disease" hypothesis, which demonstrated geographic correlations between early-life deprivation and adult cardiovascular disease mortality across English counties. The theory has evolved beyond hypothesis status, supported by cohort studies, animal models, and research demonstrating how intrauterine and early-life conditions influence later risk of non-communicable diseases. Professor Yajnik discusses his collaboration with Barker beginning in 1991 and explains why India provided an ideal research setting given its high prevalence of low birth weight and rapidly increasing diabetes rates. He highlights the "Yajnik-Yudkin (YY) paradox," demonstrating that Indians develop diabetes at younger ages with lower BMI but higher body fat percentages compared to Europeans. The "thin-fat Indian baby syndrome" further showed that Indian newborns, despite being 800 grams lighter, exhibit proportionally higher adiposity and metabolic risk markers at birth, establishing critical evidence for DOHaD's relevance in South Asian populations and informing early-life intervention strategies.

For Healthcare Professionals Only
Nestlé Nutrition Institute

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Milestones in Maternal Nutrition - Healthy Weight Management in Pregnancy - Episode 10

Milestones in Maternal Nutrition - Healthy Weight Management in Pregnancy - Episode 10

In this episode of Milestones in Maternal Nutrition, Professor Andrew Prentice speaks with Dr. Nandita Perumal about healthy weight management before and during pregnancy. Dr. Perumal explains how bei...

19 Kesä 27min

Milestones in Maternal Nutrition - Drivers and Consequences of Low Birth Weight - Episode 9

Milestones in Maternal Nutrition - Drivers and Consequences of Low Birth Weight - Episode 9

In this episode of Milestones in Maternal Nutrition, Professor Andrew Prentice speaks with Professor Parul Christian about the drivers and lifelong consequences of low birth weight. Professor Christia...

4 Kesä 27min

Milestones in Maternal Nutrition - INTERGROWTH-21st Project - Episode 8

Milestones in Maternal Nutrition - INTERGROWTH-21st Project - Episode 8

In this episode of Milestones in Maternal Nutrition, Professor Andrew Prentice and  Professor Stephen Kennedy talk about the INTERGROWTH-21st Project and its contribution to the assessment of fetal an...

3 Kesä 29min

Milestones in Maternal Nutrition - Combating Maternal Anemia - Episode 7

Milestones in Maternal Nutrition - Combating Maternal Anemia - Episode 7

For Healthcare Professionals OnlyNestlé Nutrition Institute

2 Kesä 27min

Milestones in Maternal Nutrition - Long-chain Fatty Acids in Pregnancy - Episode 6

Milestones in Maternal Nutrition - Long-chain Fatty Acids in Pregnancy - Episode 6

In this episode of Milestones in Maternal Nutrition, Professor Andrew Prentice interviews Professor Maria Makrides, exploring the evolving science of long-chain omega-3 fatty acids during pregnancy an...

1 Kesä 28min

Milestones in Maternal Nutrition - Protein Energy Supplements in Pregnancy - Episode 5

Milestones in Maternal Nutrition - Protein Energy Supplements in Pregnancy - Episode 5

In this episode of Milestones in Maternal Nutrition, Professor Andrew Prentice with Professor Kathryn Dewey talks about the role of protein-energy supplementation during pregnancy and its potential to...

15 Touko 33min

Milestones in Maternal Nutrition - Multiple Micronutrient Supplements in Pregnancy - Episode 4

Milestones in Maternal Nutrition - Multiple Micronutrient Supplements in Pregnancy - Episode 4

In this episode of Milestones in Maternal Nutrition, Professor Andrew Prentice speaks with Dr. Klaus Kraemer about the development and the science behind UNIMMAP — the standardized multiple micronutri...

14 Touko 29min

Milestones in Maternal Nutrition - Folic Acid Prevents Neural Tube Defects - Episode 3

Milestones in Maternal Nutrition - Folic Acid Prevents Neural Tube Defects - Episode 3

In this episode of Milestones in Maternal Nutrition, Professor Andrew Prentice speaks with Professor Helene McNulty about the landmark evidence linking periconceptional folic acid supplementation to t...

13 Touko 21min

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