unPAUSED with Dr. Mary Claire Haver30 Kesä

Gut, Brain, and Hormones: The Menopause Connection with Dr. Amy Shah

In this episode of unPAUSED, Dr. Mary Claire Haver sits down with Dr. Amy Shah, a physician trained in internal medicine and immunology with a nutrition background from Cornell, and author of the new book Hormone Havoc.

Dr. Haver and Dr. Shah begin the conversation with the gut-hormone-brain connection, explaining how 40% of estrogen is recirculated through the gut, how the estrobolome, the collection of gut bacteria responsible for metabolizing estrogen, determines how much the body retains, and why declining estrogen in perimenopause and menopause triggers a cascade that loosens the tight junctions meant to keep food particles, toxins, and viruses from entering the bloodstream. This leaky gut drives inflammation that accelerates every symptom women are already experiencing, from weight gain and mood changes to sleep disruption and brain health decline. The gut-brain axis, the constant two-way communication between the gut and the brain, means that what is happening in the gut is directly shaping cognitive function, motivation, and emotional resilience in menopause. She also covers how 95% of serotonin is made in the gut, why chronic inflammation reroutes tryptophan away from serotonin and melatonin, and what that means for mood, sleep, and appetite in midlife.

Guest links:

Dr. Amy Shah (Instagram)

Dr. Amy Shah (TikTok)

Dr. Amy Shah

Save Yourself With Dr. Amy Shah (Apple Podcasts)

Books:

“Hormone Havoc: A Science-Backed Protocol for Perimenopause and Menopause: Sleep Better. Think Better. Feel Better,” by Dr. Amy Shah

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Women’s Health Issues Doctors Too Often Miss with CNN’s Pamela Brown

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9 Loka 47min

How Menopause Changes Your Gut Health with a Leading Gastroenterologist

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Menopause Skin Treatments: Botox, Lasers and Lifestyle

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2 Loka 35min

Menopause Skin Changes and the Science of Skincare

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29 Syys 46min

Building Muscle in Menopause: Protein, Creatine and Strength Training with Dr. Gabrielle Lyon

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22 Syys 56min

Menopause Masterclass: Why Your Hair Is Thinning and What Works

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Melinda French Gates Is Fighting to Close the Menopause Funding Gap

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8 Syys 46min