Dr Brendan Khong on Inflammaging, Regenerative Aesthetics and Skin Health

In this episode, I sit down with Dr Brendan Khong, a London-based aesthetic physician and regenerative medicine advocate, for a practical conversation about what it really means to age well, starting with the skin, but quickly expanding into whole-body biology.

The central theme is a shift now reshaping aesthetic medicine: moving away from surface-level fixes and toward addressing the underlying drivers of visible ageing. A key driver, Dr Brendan explains, is inflammaging, a chronic, low-grade inflammation that builds over time and accelerates both skin ageing and broader physiological decline.

He breaks down why some conventional aesthetic approaches can backfire, particularly repeated high-heat energy treatments, which may contribute to fibrosis, uneven pigmentation, and a dull, “waxy” skin texture over time. His approach favours smarter, gentler interventions, including an anti-inflammatory 1064nm Nd:YAG laser, targeted resurfacing that can be safer across a wider range of skin types, and calming injectables such as Meso-Wharton (a peptide product derived from Wharton’s jelly) used in practice to support skin quality, texture and fine lines.

But this is not just a conversation about devices and injectables. Dr Brendan argues that better results start with better assessment and the need to factor in gut health, supplement use, stress load, and cortisol patterns before reaching for a needle or a laser. He is also candid about timelines: collagen remodelling takes time, and unrealistic expectations are one of the biggest problems in aesthetics.

For day-to-day longevity habits that support skin health, he highlights fundamentals that are often overlooked: exercise, stress management, avoiding very hot showers, and finding a retinoid your skin can consistently tolerate.

Dr Brendan Khong | London's Most Sought-after Aesthetic Doctor

Dr Brendan Khong (@drbrendankhong) • Instagram profile

00:00 Welcome and Guest Intro

02:06 Brandon’s Medical Journey

03:36 Skin as an Inflammation Mirror

07:19 Supplements and Gut Health

10:15 Overtreatment and Inflammaging

14:47 Anti-Inflammatory Laser Approach

17:39 Regenerative Injectables Peptides

21:36 Personalised Protocols and Expectations

25:18 Why Glanine Stands Out

25:57 Microspheres Not Clumps

26:55 Anti-Inflammatory Collagen

27:47 Safety Profile Focus

28:45 Building Patient Protocols

30:25 Longevity Over Quick Fixes

32:17 Future Of Aesthetics

33:41 Gentler Treatment Philosophy

34:49 Quantum Magnetic Resonance

36:18 Healthy Beauty Trends

37:25 Daily Longevity Skin Tips

40:10 Rapid Fire Longevity Qs

45:14 Final Takeaways And Wrap