Why biomining might finally work: How Endolith is using microbes and data to unlock more copper from low-grade ore

Copper is moving from background commodity to frontline constraint. Demand is rising fast, high-grade deposits are getting harder to find, and the lead times for bringing new supply online remain brutally long. That matters not just for renewables and electrification, but for the basic energy resilience of modern life: the wires that keep lights on, water running, refrigeration working, and data centres scaling all depend on a metal the industry already knows is becoming harder to source.

Host Sylvia Leyva Martinez is joined by Liz Dennett, founder and CEO of Endolith, whose career spans Wood Mackenzie, AWS, and NASA-linked astrobiology research, to explore a biological approach to one of mining’s toughest problems. Endolith uses microbial communities, what Dennett calls “the world’s oldest miners," to help recover more copper from low-grade ore in existing heap leach operations. The company’s core thesis is that copper supply can be made more elastic not by rebuilding mine sites from scratch, but by layering biology, sensing, and robust data architecture into brownfield operations that are already running.

Liz explains how that works on site: low-grade ore is stacked into large heaps, irrigated with sulfuric acid, and treated with microbes that accelerate the chemical pathways needed to liberate more copper into solution. The appeal is not futuristic moonshot capex, but a modular, plug-and-play system designed to fit into existing mine infrastructure with minimal downtime. The discussion looks at why that matters economically. Endolith is targeting ore bodies and waste streams that are currently too messy, too low grade, or too contaminated to recover efficiently through conventional routes, including arsenic-rich material that can be especially problematic for smelting. In lab settings, the company has seen significantly higher recovery, and even modest incremental gains in the field could translate into a meaningful unlock when the underlying mine and processing system are already built.

The conversation also asks why biomining may be having its moment now, after decades of false starts. Liz argues that the breakthrough is not microbes alone, but the combination of microbial science, cloud-scale data systems, and faster experimentation that lets teams build and iterate far more effectively than even a few years ago. From there, the conversation broadens into the strategic question underneath Endolith’s business: how to increase copper supply in a world where demand is being pushed simultaneously by grid build-out, industrial electrification, and the explosive growth of AI infrastructure. The episode closes on the trade-offs that follow from that reality, from financing hard-tech mining solutions to building companies in sectors where the need is obvious, the customers are conservative, and proof matters more than hype.

This Horizons episode Liz refers to can be found here:

https://www.woodmac.com/podcasts/horizons/red-metal-green-demand/

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