Rethinking Tuberculosis: Why Enhancing Immune Responses in Tuberculosis Might be Detrimental - Dr. Mohamed Ahmed
The Immunology in Africa Podcast14 Joulu 2022

Rethinking Tuberculosis: Why Enhancing Immune Responses in Tuberculosis Might be Detrimental - Dr. Mohamed Ahmed

Mohamed Ahmed (PhD) is a fellow of the Sub-Saharan African Network for TB/HIV Research Excellence (SANTHE) and a recent PhD graduate of the Africa Health Research Institute (AHRI) associated with the University of Kwa-Zulu Natal in Durban, South Africa. In this episode, he talks about his return to tuberculosis (TB) research for his PhD after a not-so-motivating undergraduate experience. His PhD research showed that Interferon-gamma, a key regulator of TB immunity, interacts with Mycobacterium tuberculosis (Mtb), the bacterium that causes TB. This interaction, which increases Mtb virulence and metabolism, worsens TB infection. His findings add to a growing body of evidence suggesting that excessive immune responses might paradoxically be harmful to the control of human TB. In addition, the ability of Mtb to sense Interferon-gamma indicates an evolutionary measure to counter host immunity and enhance bacterial survival.

Current efforts to develop TB vaccines depend on boosting immune responses, as it is believed that natural immunity is inadequate to prevent disease. Mohamed hopes that the findings of his PhD research could inform future therapeutic and vaccine strategies to design more effective means to combat TB.

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