The Truth About Hormones and Your Skin—A Top Endocrinologist and Dermatologist Explain

What actually happens to skin when your hormones change? In this unfiltered episode, we sit down with powerhouse (twin!!) sisters Dr. Florence Comite, Yale & NIH-trained endocrinologist and author of the NY Times Bestseller: Invincible: Defy Your Genetic Destiny to Live Better, Longer and board-certified dermatologist Dr. Harriet Comite to connect the dots between hormones, endocrinology and skin health.

You’ll hear about:

• The perimenopause skin shift: Why fluctuating estrogen and plunging testosterone wreck your skin pH, leaving your barrier and microbiome vulnerable to skin chaos.
• Defying your genetic destiny: Dr. Florence breaks down her longevity playbook for rewriting your health span through epigenetics, deep sleep, and tracking the right biomarkers before stuff hits the fan.
• Acne & barrier health: Why adult breakouts demand serious intervention and why your basic bar soap belongs nowhere near your face.
• Peptides & GLP-1s demystified: The systemic reality of GLP-1 weight loss, rapid volume loss, and what actually happens when Silicon Valley bro-stacks BPC-157 and GHK-Cu ("the glow injection").
• Topical estrogen myth vs. reality: The science behind applying prescription estrogen cream on your face versus what systemic Menopause Hormone Therapy (MHT) actually delivers.
• Biomarkers you cannot ignore: The five metabolic markers that Dr. Florence says you need to know now to empower your future health
• Sun protection & vitamin D: The critical breakdown between UVA and UVB damage, and why your daily mineral SPF 50+ needs a serious oral vitamin D3/K2 backup.

Disclaimer: Please note the discussion in today’s podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or qualified healthcare provider with any questions you may have regarding a medical condition.

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🎙️ For more related conversations like this, check out these episodes:

• Acne Secrets, Accutane Myths & More with Dermatologist Dr. Amy Wechsler
• The *New* Rules of Skin Brightening, Laser “Stacking” and Why Everyone is Freaking Out Over Xerf with Dermatologist Dr. Tia Paul
• Vagina Care Do’s & Don’ts with Dr. Jen Gunter, Social Media’s Resident Gyno and Anti-GOOP Advocate

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Hosts: Carlene Higgins and Jill Dunn

Theme song, used with permission: Cherry Bomb by Saya


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