Dave’s Anti-Aging Skincare Routine: Exosomes, Methylene Blue & NAD+ : 1547

Visit https://www.younggoose.com/ and use code ASPREY10 to save on the skin longevity products discussed in this episode.

Skin Longevity, Cellular Repair, Red Light Therapy & the Biology of Younger Skin with Young Goose

Host Dave Asprey sits down with Amitay Eshel and Anastasia Khodzhaeva, co-founders of Young Goose, to explore the emerging science of skin longevity, cellular aging, mitochondrial function, exosomes, NAD+, red light therapy, and what it may take to keep skin functioning younger for longer.

Anastasia is a biologist, biohacker, and co-CEO of Young Goose who began her career in biomedical research focused on liver fibrosis and breast cancer before moving into wellness, product development, and longevity-focused skincare. Amitay is co-founder and CEO of Young Goose and host of the Biohacking Beauty podcast, with more than a decade of experience across health, wellness, beauty, and business development. Together, they focus on applying longevity science and performance optimization to skin health.

Amitay and Anastasia explain why wrinkles may be only one visible sign of a much deeper biological process involving declining cellular energy, weakened barrier function, oxidative stress, senescence, and changes in how skin cells repair themselves. They break down how newer approaches to skincare are moving beyond surface-level hydration toward targeting the cellular mechanisms associated with aging.

The conversation goes deep into testing, including a metabolomics-based approach designed to assess skin metabolic age from a small blood sample and analyze 17 different metabolites. They also discuss emerging proteomics testing that can examine thousands of proteins involved in processes such as collagen production, oxidative stress, mitochondrial function, and cellular repair.

Dave, Amitay, and Anastasia explore some of the most unusual compounds now being used in skin longevity, including methylene blue, NAD+ precursors, spermidine, ergothioneine, superoxide dismutase, copper peptides, ectoin, and gotu kola. They explain how these compounds may interact with mitochondrial energy production, oxidative stress, mitophagy, collagen signaling, and the broader hallmarks of aging.

They also break down red light therapy and why combining light with certain topical compounds may influence the response. The discussion covers methylene blue and electron transport, copper peptides and mitochondrial biogenesis, light-activated DNA repair enzymes, photodamage, reactive oxygen species, and why dose and timing may matter when using red or near-infrared light.

The episode also dives into platelet-derived “Vampire Exosomes,” how exosomes carry cellular instructions through microRNAs, why formulation and stability matter, and how these signaling particles may influence skin repair, inflammation, collagen production, and senescence. Dave and the Young Goose team also discuss growth factors, klotho, senomorphic strategies, cellular longevity, and why extending the functional life of healthy cells may become an important frontier in longevity science.

They also explore practical skincare routines, including how to layer products, what Dave uses while traveling, how airplanes and dry environments affect skin, why aggressive acids may not always fit a long-term skin longevity strategy, and how AI-based skin analysis could make skincare increasingly personalized.

This is essential listening for anyone interested in skin longevity, anti-aging skincare, exosomes, methylene blue, NAD+, red light therapy, mitochondrial health, senescent cells, collagen, peptides, cellular repair, metabolomics, proteomics, biohacking, and the future of personalized skincare.

You’ll Learn:

• Why wrinkles may be a downstream sign of deeper cellular aging
• How skin metabolic age can be assessed using metabolomics and multiple biological markers
• What methylene blue may do inside mitochondria and why it pairs with red light
• How NAD+ precursors, spermidine, copper peptides, SOD, and ergothioneine may support skin biology
• Why platelet-derived “Vampire Exosomes” are being studied for cellular signaling, repair, and senescence
• How red light therapy interacts with mitochondrial function, oxidative stress, and DNA repair
• Why some traditional acids and surface-level skincare strategies may not address long-term skin function
• How proteomics and AI could change the way skincare is measured and personalized
• What Dave and the Young Goose team use to support skin during travel and other high-stress environments

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Amitay Eshel, Anastasia Khodzhaeva, Young Goose, Biohacking Beauty, skincare, anti-aging skincare, skin longevity, skin aging, younger skin, exosomes, vampire exosomes, platelet-derived exosomes, methylene blue, NAD+, NAD precursors, red light therapy, mitochondria, mitochondrial health, mitochondrial dysfunction, cellular aging, cellular repair, senescent cells, senescence, senomorphics, collagen, copper peptides, GHK-Cu, spermidine, ergothioneine, superoxide dismutase, SOD, ectoin, gotu kola, mitophagy, metabolomics, proteomics, skin metabolic age, klotho, oxidative stress, peptides, skin barrier, DNA repair, photodamage, biohacking, longevity

Resources:

• Visit https://www.younggoose.com/ and use code ASPREY10 to save on the skin longevity products discussed in this episode.

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Timestamps:

00:00 — Trailer

01:09 — Skin Testing & Metabolomics

04:48 — Longevity Skincare Paradigm

07:50 — Airplane Skincare Routine

11:15 — Tardigrade Juice & Antioxidants

16:00 — Mitochondrial Dysfunction

21:00 — Skincare Ingredients: Old vs New

27:20 — Vampire Exosomes

32:30 — Red Light Therapy Stacking

38:00 — Proteomics & Klotho

41:00 — Exosome Safety, Growth Factors & MicroRNAs

44:00 — Senescent Cells & Senomorphics

47:00 — Skin Longevity Takeaways

50:00 — Outro

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