Declining ALS Patients Are Waiting On The FDA's Next Move
Big Take23 Joulu 2022

Declining ALS Patients Are Waiting On The FDA's Next Move

For many years, pharmaceutical companies have tried and failed to find a treatment to slow symptoms of ALS–the debilitating, fatal illness also known as Lou Gehrig’s Disease. A potentially promising new drug from Biogen may offer some relief to those afflicted with an uncommon and especially insidious form of ALS that runs in families. Patients are urging the US Food and Drug Administration to speed access to the drug, which hasn’t yet been approved because clinical trials didn’t conclusively show it works.

As pharmaceutical companies use new technologies to seek cures of all kinds, this tension between making sure drugs are effective and safe, and offering not-quite-ready but possibly life-saving treatment to people for whom it’s now or never, is becoming more acute.

Bloomberg’s chief medical writer Robert Langreth joins this episode to talk about the race to find a treatment for ALS–and the back and forth between patients, companies and government regulators. We also hear the story of a Pennsylvania family that has passed on a gene for ALS from generation to generation–and their demands for access to the new treatment.

Learn more about the episode here: https://bloom.bg/3WIkvCm

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Inside Trump’s Retribution Campaign

Inside Trump’s Retribution Campaign

On Monday, a federal judge threw out the criminal cases filed by the Department of Justice against former FBI director James Comey and New York Attorney General Letitia James. When President Trump took office in January, he made it clear that retribution against his perceived political enemies was a key part of his second-term agenda. The cases against Comey and James were a high profile part of that strategy, and the White House does not seem inclined to accept this outcome. On today’s Big Take podcast, host Sarah Holder is joined by Bloomberg senior national political reporter Nancy Cook and Department of Justice reporter Chris Strohm to discuss the stakes of the Comey and James cases, the role the DOJ has played in carrying out Trump’s second-term agenda — and what to expect next.See omnystudio.com/listener for privacy information.

25 Marras 19min

Checking the Math on Trump’s $2,000 Checks

Checking the Math on Trump’s $2,000 Checks

Under new pressures over inflation and affordability, President Donald Trump has been talking up a plan to share tariff revenues with Americans, in the form of $2,000 checks. But there are several major problems with this plan — and he’s lacking support among some of his most ardent allies. On today’s Big Take episode, host Sarah Holder is joined by Bloomberg senior national political reporter Nancy Cook and US Treasury reporter Dan Flatley to discuss how Trump’s latest proposal fits into the economic debate that could define midterm elections – and how the Supreme Court, the Republican party and Trump’s own cabinet could throw a wrench in his plans. Read more: Trump’s $2,000 Tariff ‘Dividend’ Marks Throwback to Covid Checks Trump’s $2,000 Tariff Check Idea Draws Republican Resistance See omnystudio.com/listener for privacy information.

24 Marras 18min

Harassment Concerns at Oxford Went Unaddressed for Years

Harassment Concerns at Oxford Went Unaddressed for Years

Oxford University has repeatedly been slow to act when confronted with allegations of harassment, assault and inappropriate behavior by male academics, a new Bloomberg investigation has found. Katherine Griffiths, the city editor of Bloomberg’s London bureau, spoke to dozens of academics, staffers and women who have studied at Oxford to understand how the storied institution has handled misconduct concerns — and why it lags behind its peers. On this episode of the Big Take podcast, she shares her findings about the barriers to addressing misconduct at Oxford, and the lasting consequences for women. Read more: Oxford University Has Failed Women Over Harassment Concerns, Staff SaySee omnystudio.com/listener for privacy information.

21 Marras 20min

Nvidia Silences AI Skeptics (For Now)

Nvidia Silences AI Skeptics (For Now)

Nvidia released its third quarter earnings Wednesday, crushing estimates and easing Wall Street’s concerns about an AI bubble. On today’s Big Take podcast, Bloomberg Tech’s Ed Ludlow sits down with David Gura to discuss his post-earnings interview with Jensen Huang – what the Nvidia CEO had to say about the company’s breakneck growth, so-called circular deals, and potential expansion into China. Read more: Nvidia’s Huang Says Company Has Plenty of New Chips to Sell It's OK, Nvidia Says There's No AI Bubble See omnystudio.com/listener for privacy information.

20 Marras 18min

The Hot Market for Jobs No One Wants

The Hot Market for Jobs No One Wants

After a period characterized as “low-hire, low-fire,” the American labor market is seeing a surge of layoffs from companies like Amazon, Starbucks, UPS and Target. And that’s pushing more job applicants towards traditionally less-desirable occupations, like substitute teaching, traffic flagging and waste management. Today on the Big Take, Sarah Holder is joined by economic reporter Mike Sasso to discuss what’s happening in this often-overlooked corner of the labor market and what it means for the economy overall. Read more: The Job Market Is Heating Up — for Jobs That People Usually Don't WantSee omnystudio.com/listener for privacy information.

19 Marras 14min

China Tests the Limits in the Race for Biotech Power

China Tests the Limits in the Race for Biotech Power

China is investing heavily in cutting-edge genetic experiments. It’s part of their quest to become a biotech superpower. On today’s Big Take Asia Podcast, host K. Oanh Ha, Bloomberg’s Karoline Kan and Oxford University geneticist Andy Greenfield discuss China’s pharmaceutical ambitions and the loose regulatory environment that allows the animal testing industry to thrive. Read more: China Pushes Boundaries With Animal Testing to Win Global Biotech RaceSee omnystudio.com/listener for privacy information.

18 Marras 19min

How Private Equity Got Its Hands on Billions in Americans’ Retirement Money

How Private Equity Got Its Hands on Billions in Americans’ Retirement Money

Apollo Global Management reinvented how pensions could be managed and paid out — by taking them over and moving the risks offshore. Other firms have followed suit and ushered hundreds of billions of dollars in American retirement savings into accounts that retirees and economists say are exposed to higher risk. On today’s Big Take podcast, host Sarah Holder sits down with Bloomberg reporters Alex Rajbhandari and Tom Schoenberg, who investigated this phenomenon and explain what it means for the people whose nest eggs ended up on private equity’s opaque balance sheets. Read more: The Offshoring of America’s Retirement Savings When Wall Street’s Insurance Playbook Goes Wrong See omnystudio.com/listener for privacy information.

17 Marras 19min

They Voted for Trump. His Tariffs Took Down Their Family-Owned Sawmill

They Voted for Trump. His Tariffs Took Down Their Family-Owned Sawmill

For years, Mackeys Ferry Sawmill in North Carolina relied on exporting its goods to China and Vietnam after a dip in domestic demand for high-quality hardwood. But President Donald Trump’s trade war with China dealt a blow that the mill’s owners say they couldn’t come back from. In July, just months after the president announced his “Liberation Day” tariffs, they decided to shut it down. On today’s Big Take podcast, Bloomberg economics reporter Shawn Donnan goes to the “Old North State” to understand the ripple effect of tariffs on one of the oldest industries in America and how the mill’s owner feels about Trump and his policies, one year after voting for him in the ballot booth. Listen more: The Most Worrying — and Reassuring — Signals in the US EconomySee omnystudio.com/listener for privacy information.

14 Marras 20min

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