Narcolepsy: A Review

Narcolepsy: A Review

Narcolepsy is a chronic neurologic disorder that causes severe daytime sleepiness and impaired quality of life. Author Tom Scammell, MD, of Harvard Medical School joins JAMA Deputy Editor Karen Lasser, MD, MPH, to discuss the etiology, clinical presentation, diagnostic evaluation, and treatment of narcolepsy.

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Heart Transplant for Advanced Heart Failure

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Heart transplant for patients with advanced heart failure can lead to improved survival and quality of life. Author JoAnne Lindenfeld, MD, of Vanderbilt University joins JAMA Associate Editor David Si...

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Influenza, RSV, and COVID-19 Vaccines: Effectiveness, Safety, and Trust in 2026

Influenza, RSV, and COVID-19 Vaccines: Effectiveness, Safety, and Trust in 2026

Respiratory virus vaccine effectiveness and safety for influenza, RSV, and COVID-19 are reviewed, including new evidence, risks, and recommendations. JAMA Deputy Editor Preeti Malani, MD, MSJ, speaks ...

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Vaccines for Cancer Treatment

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Cancer vaccines stimulate immune cells to recognize proteins or mutations found on or within cancer cells, facilitating destruction of cancer cells. Several vaccines are approved and others are in dev...

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Idiopathic Normal Pressure Hydrocephalus: Diagnosis and Treatment

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Idiopathic normal pressure hydrocephalus (iNPH) affects approximately 1% to 4% of adults aged 65 years and older and is associated with gait impairment, cognitive decline, and urinary dysfunction. Aut...

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Rheumatoid Arthritis

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Rheumatoid arthritis can affect any synovial joint and cause irreversible damage, but early diagnosis and treatment with DMARDs can reduce inflammation and lower the risk of joint destruction. JAMA As...

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An Overview of Postural Orthostatic Tachycardia Syndrome (POTS)

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POTS is a chronic autonomic disorder characterized by excessive orthostatic tachycardia and multisystem symptoms that affects an estimated 0.1% to 1% of the US population. Author Satish Raj, MD, MSCI,...

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Medication Treatments for Alcohol Use Disorder

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Naltrexone, acamprosate, disulfiram, and topiramate are effective but underused medications for treatment of alcohol use disorder. Author Stephen Holt, MD, MS, of Yale School of Medicine joins JAMA De...

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