1005: David Fajgenbaum | Leveraging AI to Cure Rare Diseases

What challenges can the ocean help us meet, and what must we do to safeguard its treasures? The Underworld author Susan Casey dives deep for answers here! What We Discuss with Susan Casey: The ocean plays a crucial role in regulating the Earth's climate and serves as the largest carbon sink on the planet, making its preservation essential for mitigating climate change. The ocean is home to a fascinating array of creatures that have adapted to extreme conditions, such as iron-breathing microbes, glass sponges, and jellyfish that can reverse their life cycle. Pollution, including plastics, chemical weapons, and nuclear waste, has severely impacted the ocean ecosystem, with some deep-sea creatures found to have plastic particles embedded in their organs. There are an estimated three million shipwrecks on the ocean floor, preserving valuable historical artifacts and information — such as the Antikythera mechanism, an ancient Greek analog computer. Exploring the ocean can lead to groundbreaking discoveries in medicine, Earth's history, and climate, providing valuable insights for addressing humanity's challenges — provided we safeguard this treasury of knowledge for current and future generations. And much more... Full show notes and resources can be found here: jordanharbinger.com/984  This Episode Is Brought To You By Our Fine Sponsors: jordanharbinger.com/deals  Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course!  Like this show? Please leave us a review here — even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

30 Huhti 20241h 22min

Your brother's never-ending barrage of goat-related songs, text messages, and references has your family concerned. Welcome to Feedback Friday! And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Gabriel Mizrahi (@GabeMizrahi) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! On This Week's Feedback Friday, We Discuss: An innocent bystander might find your brother's weird obsession with goats amusing, but his barrage of goat-related songs, text messages, and references has your family concerned. What can you do to herd him back to reality? Feeling unwelcome as the only woman at a family card game, you struggle with self-doubt and question your husband's support. How can you navigate family dynamics while staying true to yourself? Despite not being officially charged by the DA for public intoxication and alleged indecent exposure (the latter of which you deny), your six-year career as a firefighter is in jeopardy. What are your options? [Thanks to police agency supervisor T.D. De La Peña for helping us with this one!] As a small business co-owner, you face a dilemma: stay in a potentially profitable but stressful partnership or leave with decent earnings, which would have a negative impact on the company's stability and your (ex-)business partner. Have any questions, comments, or stories you'd like to share with us? Drop us a line at friday@jordanharbinger.com! Connect with Jordan on Twitter at @JordanHarbinger and Instagram at @jordanharbinger. Connect with Gabriel on Twitter at @GabeMizrahi and Instagram @gabrielmizrahi. Full show notes and resources can be found here: jordanharbinger.com/983 This Episode Is Brought To You By Our Fine Sponsors: jordanharbinger.com/deals Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Huhti 20241h 2min

Should we worry that the complex dynamics between Israel and Iran might ignite WWIII? Intelligence analyst Ryan McBeth brings us in from Out of the Loop. Welcome to what we're calling our "Out of the Loop" episodes, where we dig a little deeper into fascinating current events that may only register as a blip on the media's news cycle and have conversations with the people who find themselves immersed in them. On This Episode of Out of the Loop: Israel and Iran have been engaged in recent attacks on each other, with Israel striking Iranian officers in Syria, Iran launching drones at Israel, and Israel firing missiles back at Iran. However, neither side seems to want a wider conflict. Iran's military is split between the regular Artesh forces and the Islamic Revolutionary Guard Corps (IRGC). The IRGC gets better equipment and training and has a Quds Force that specializes in unconventional warfare. Iran and Israel both lack strong expeditionary capabilities to directly attack each other. Iran's navy is mostly small fast attack boats, while Israel has a defensive-oriented military. Many ordinary Iranian citizens oppose their government and the Ayatollahs. The people should not be conflated with the regime. Iran has a large young population that is quite pro-Western. Overall, a massive conventional war between Israel and Iran remains unlikely due to the geographic and military constraints on both sides, despite the harsh rhetoric. However, proxy conflicts and tit-for-tat strikes may continue. And much more! Full show notes and resources can be found here: jordanharbinger.com/982 This Episode Is Brought To You By Our Fine Sponsors: jordanharbinger.com/deals Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course! Like this show? Please leave us a review here — even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

25 Huhti 20241h

Grab a front-row seat to the gritty world of bare-knuckle boxing with undefeated champ Bobby Gunn and his 'Bare Knuckle' biographer Stayton Bonner here! What We Discuss with Bobby Gunn and Stayton Bonner: The culture and traditions of — as well as the stereotypes, lifestyle choices, and challenges faced by — the traveler community in which Bobby was raised. How Bobby started fighting drunks for money at the not-so-tender age of 11. The rich history — and brutal realities — of bare-knuckle boxing. How Bobby answered the call of the underground bare-knuckle boxing circuit and what the costs have been along the way. The evolution of bare-knuckle boxing, and Bobby's indelible mark on the sport.  And much more... Full show notes and resources can be found here: jordanharbinger.com/981  This Episode Is Brought To You By Our Fine Sponsors: jordanharbinger.com/deals  Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course!  Like this show? Please leave us a review here — even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23 Huhti 20241h 15min

Your pregnant sister-in-law was a wild child growing up and suffers addiction. Would adopting her baby disrupt your family life? Welcome to Feedback Friday! And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Gabriel Mizrahi (@GabeMizrahi) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! On This Week's Feedback Friday, We Discuss: Whenever you're hit with a double-whammy of physical illness and depression, remember that psychology is, in fact, biology. Metacognition is the key. Your pregnant sister-in-law was a wild child growing up and suffers from addiction. Would adopting her baby disrupt your own family's tranquility? What's the most drama-free way to get your professional contacts on board with the changes you've made since coming out as transgender? [Thanks to Noelle Soncrant, the first visible transgender financial advisor at Northwestern Mutual, for helping us with this one!] You just discovered your wife has a warrant for her arrest after neglecting to pay $173,000 in taxes your co-owned and recently dissolved business owes to the IRS. Now what? [Thanks to bankruptcy attorney Erin Hoskins for giving us some sound advice here!] Your sister left her amazing husband for a man she finds more attractive — but who also exhibits controlling and manipulative behavior. He's pressuring her to have a baby despite her lifelong decision against it. How can you help her realize she's making a huge mistake? How can you mitigate career setbacks while taking time off from work to travel? Have any questions, comments, or stories you'd like to share with us? Drop us a line at friday@jordanharbinger.com! Connect with Jordan on Twitter at @JordanHarbinger and Instagram at @jordanharbinger. Connect with Gabriel on Twitter at @GabeMizrahi and Instagram @gabrielmizrahi. Full show notes and resources can be found here: jordanharbinger.com/980 This Episode Is Brought To You By Our Fine Sponsors: jordanharbinger.com/deals Sign up for Six-Minute Networking — our free networking and relationship...See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19 Huhti 20241h 19min

What's it like to be one of the only Muslim Arab Americans fighting terrorism in the US' most secret military unit? Adam Gamal shares here in part 2 of 2! [Part 1 can be found here.] What We Discuss with Adam Gamal: How Adam Gamal went from being an Egyptian refugee who barely spoke English to an operative in the United States' most secret special forces unit. The unit's tasks range from counterterrorism and hostage rescue to counter-narcotics operations. The ethical and emotional complexities of covert operations. How top secret operatives navigate cultural nuances while making personal sacrifices for the greater good. The importance of intelligence, adaptability, and the unseen battles fought every day to ensure American safety. And much more... Full show notes and resources can be found here: jordanharbinger.com/979  This Episode Is Brought To You By Our Fine Sponsors: jordanharbinger.com/deals  Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course!  Like this show? Please leave us a review here — even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

18 Huhti 20241h 7min

What's it like to be one of the only Muslim Arab Americans fighting terrorism in the US' most secret military unit? Adam Gamal shares here in part 1 of 2! What We Discuss with Adam Gamal: How Adam Gamal went from being an Egyptian refugee who barely spoke English to an operative in the US Army's most secret special forces unit. The unit's tasks range from counterterrorism and hostage rescue to counter-narcotics operations. The ethical and emotional complexities of covert operations. How top secret operatives navigate cultural nuances while making personal sacrifices for the greater good. The importance of intelligence, adaptability, and the unseen battles fought every day to ensure American safety. And much more... Full show notes and resources can be found here: jordanharbinger.com/978 This Episode Is Brought To You By Our Fine Sponsors: jordanharbinger.com/deals Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course! Like this show? Please leave us a review here — even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

16 Huhti 20241h 12min

We have a follow-up from our episode 904 listener on her Persian boyfriend's hesitation to advance their six-year relationship. Welcome to Feedback Friday! And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Gabriel Mizrahi (@GabeMizrahi) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! On This Week's Feedback Friday: What are the benefits of raising a resilient child? Daily Dad Ryan Holiday counts the ways. An update from the listener who wrote in on episode 904 regarding her Persian boyfriend's reluctance to commit to the next step of their six-year relationship. (Hint: it's got very little to do with his family's acceptance of her non-Persianness.) As a Mandarin-speaking American quickly rising within a Chinese-owned organization, you find the inevitable influence of the CCP over the fate of your company and career to be suboptimal. How do you reconcile the broader moral objections of your work with your responsibility to ensure financial stability for your family moving forward? Getting divorced would be financially disastrous, but marriage to someone who lacks critical thinking skills, is incapable of reading the simplest of context clues, and can't come to any opinion he isn't told by his parents, church, or political movement is exhausting. What are your options? In the event of your untimely demise, how do you keep your kids safe from your estranged, narcissistic, abusive, BPD-afflicted, manipulative, and generally toxic parents? [Thanks to trust and estate attorney and judge Jordan Richards for helping us with this one!] Hey, bro, if you need us to hook you up with Carl's DNA-altering money pills (as mentioned on episode 941), your business may be failing for reasons completely unrelated to the ones you're imagining. But we have thoughts... Have any questions, comments, or stories you'd like to share with us? Drop us a line at friday@jordanharbinger.com! Connect with Jordan on Twitter at @JordanHarbinger and Instagram at @jordanharbinger. Connect with Gabriel on Twitter at @GabeMizrahi and Instagram @gabrielmizrahi. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12 Huhti 20241h 13min