1005: David Fajgenbaum | Leveraging AI to Cure Rare Diseases

David Buss (@ProfDavidBuss) is a professor of psychology at the University of Texas at Austin. He is considered the world’s leading scientific expert on strategies of human mating, and his most recent book is — appropriately enough — The Evolution of Desire: Strategies of Human Mating. [Note: This is a previously broadcast episode from the vault that we felt deserved a fresh pass through your earholes!] What We Discuss with David Buss: Why does mating matter? The mating crisis among educated women. How to select a good long-term mate. What leads to mating disasters. What we can do to become better long-term mates. And much more... Full show notes and resources can be found here: jordanharbinger.com/758 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Missed our conversation with Daniel Pink in which we discussed the psychology, biology, and economics behind scheduling for optimal effect (including sleep) — and why your ideal time to get something done may widely differ from someone else’s? Catch up with episode 63: Daniel Pink | When Is the Best Time to Get Things Done? Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

1 Joulu 20221h 1min

Annie Duke (@annieduke) is a World Series poker champion, a shrewd decision-maker, and the author of Thinking in Bets: Making Smarter Decisions When You Don’t Have All the Facts and Quit: The Power of Knowing When to Walk Away. What We Discuss with Annie Duke: Why "Never give up!" is objectively terrible advice (as even Muhammad Ali might grudgingly admit). Life's too short to keep fighting a battle that's only losing ground when you could better devote the time you're spending to more worthwhile pursuits. Why the worst time to make a decision is when you're already in the middle of it. How the sunk cost fallacy keeps us spinning our wheels in fruitless attempts at progress long after we should have turned back. How we can actually tell the difference between a worthy pursuit and a lost cause — and what we can do to resist our own stubborn impulse to persist beyond reasonable defeat. And much more... Full show notes and resources can be found here: jordanharbinger.com/757 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Miss our last conversation with Annie Duke — World Series poker champion and author of Thinking in Bets: Making Smarter Decisions When You Don’t Have All the Facts? Catch up by listening to episode 40: Annie Duke | How to Make Decisions Like a Poker Champ here! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

29 Marras 20221h 20min

As a child, you were sexually abused by an older sibling, and you, in turn, abused your younger sibling. How can you overcome the guilt and shame you feel to repair your relationship with this person you've deeply hurt? We'll try to find an answer to this and more here on Feedback Friday! And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Gabriel Mizrahi (@GabeMizrahi) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! Full show notes and resources can be found here: jordanharbinger.com/756 On This Week's Feedback Friday, We Discuss: Some listener feedback about the butt-dialer situation from episode 732. As a child, you were sexually abused by an older sibling, and you, in turn, abused your younger sibling. How can you overcome the guilt and shame you feel to repair your relationship with this person you've deeply hurt? To your chagrin, the team lead in your old department — someone you consider a friend — wants you to keep helping out even though you've moved on to another position at the company. How do you navigate this without completely blowing up your friendship with this colleague? Your mother's guilt from cheating on your late father and contributing to the stress that killed him has given her an eating disorder and sapped her will to live. Is there anything you can do to bring her back from the brink? Can you be a high achiever in law school and work and still have time for family, friends, and the things you love? You were raised by a verbally and physically abusive mother, and grew up in an area where you were ethnically persecuted daily. As a result, you suffer from PTSD that therapy has only seemed to make worse, and you can't really seem to return the love you've been given in past relationships. Is it possible to find a balance between loneliness and happiness? Have any questions, comments, or stories you'd like to share with us? Drop us a line at friday@jordanharbinger.com! Connect with Jordan on Twitter at @JordanHarbinger and Instagram at @jordanharbinger. Connect with Gabriel on Twitter at @GabeMizrahi. Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Miss our conversation with actor, producer, and Scientology survivor See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

25 Marras 202257min

Dr. Sohom Das (@dr_s_das) is a consultant forensic psychiatrist who works in prisons and criminal courts to assess and rehabilitate mentally ill offenders. He is the author of In Two Minds: Stories of Murder, Justice, and Recovery From a Forensic Psychiatrist. What We Discuss with Dr. Sohom Das: Telling the difference between someone whose treatable madness is causing them to act out and someone whose irredeemable, criminal badness makes them a permanent danger to society. Over 97% of the mentally ill defendants with whom Sohom works experienced trauma in childhood. Comparing and contrasting psychopaths and sociopaths. How can a psychiatrist determine whether someone in custody is mentally ill or just faking it (and has Sohom ever been fooled)? What precautions does Sohom take for his own safety when working in close quarters with mad or bad people who mean him harm? And much more... Full show notes and resources can be found here: jordanharbinger.com/755 Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course! Miss the show we did with James Fallon — the psychiatry professor who can teach you how to spot a psychopath because he is a psychopath? Catch up here with episode 28: James Fallon | How to Spot a Psychopath! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

24 Marras 20221h 13min

Miki Mistrati (@MrMistrati) is the award-winning director of three international documentaries exposing brutal trafficking and illegal child labor in the multi-billion dollar chocolate industry: The Chocolate War, The Shady Chocolate Business, and The Dark Side of Chocolate. What We Discuss with Miki Mistrati: How human trafficking, child slavery, and inhumane treatment likely contribute to the production of your favorite chocolate products. Why, nearly two decades after pledging to eradicate child labor, major chocolate companies still cannot identify the farms where all their cocoa comes from, let alone if child labor was used in producing it. How the biggest chocolate companies wield their billions of dollars in profits to keep legislation that would hold them accountable at bay. What we, as consumers, can do to effectively censure these companies and help the people they exploit. How to ensure the chocolate we enjoy is ethically and sustainably sourced. And much more... Full show notes and resources can be found here: jordanharbinger.com/754 Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course! Miss the show we did with Vince Beiser — author of The World in a Grain: The Story of Sand and How It Transformed Civilization? Make sure to check out episode 97: Vince Beiser | Why Sand Is More Important Than You Think It Is! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

22 Marras 20221h 13min

When you're a secret crossdresser who's had a secret affair with another married man whose untimely death left you grieving in secret, it's got you wondering if you should bury your secret things before you die and your wife discovers what you've been hiding from her for all these years? We'll try to find an answer to this and more here on Feedback Friday! And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Gabriel Mizrahi (@GabeMizrahi) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! Full show notes and resources can be found here: jordanharbinger.com/753 On This Week's Feedback Friday, We Discuss: Good news! Skeptical Sundays with David C. Smalley will be back in 2023! Should you bury evidence of your crossdressing life and an affair you had with a man before your wife discovers it upon your death? Your parents want to give you and your siblings an inheritance, but how do they compassionately explain excluding your brother who's living as a monk and would have to donate his share to the Church? You envy your siblings whose lives have worked out better than yours to the point where you don't feel empathy for them when they endure terrible things — like having their houses washed out to sea in a hurricane. How can you cultivate a better attitude toward them? You've been appointed as class prefect in your high school, but your less ambitious classmates have chosen to bully you instead of following your efforts at leadership. What can you do when your peers don't respect your authority and the administration refuses to help? Should you remain as a partner at the large law firm where you've been for the past six years when your higher-ups treat you like a doormat, or should you pursue getting a fresh start somewhere new? Have any questions, comments, or stories you'd like to share with us? Drop us a line at friday@jordanharbinger.com! Connect with Jordan on Twitter at @JordanHarbinger and Instagram at @jordanharbinger. Connect with Gabriel on Twitter at @GabeMizrahi. Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course! Miss our two-parter with professional pickpocket See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

18 Marras 202250min

Angela Duckworth (@angeladuckw) is a professor of psychology at the University of Pennsylvania, founder of the non-profit Character Lab, co-host of the No Stupid Questions podcast, and author of NYT bestseller Grit: The Power of Passion and Perseverance. [Note: This is a previously broadcast episode from the vault that we felt deserved a fresh pass through your earholes!] What We Discuss with Angela Duckworth: What grit is and how it overrides the myth of innate "talent." How to quantify your own level of grit. How to grow your grit and achieve what once seemed impossible. Why, when you’re a lifelong learner, you’re always going to see in hindsight how you might have done something better in the past — and this is a sign of improvement. How to know the difference between a lost cause to abandon and a challenge worthy of pursuit. And much more... Full show notes and resources can be found here: jordanharbinger.com/752 Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course! Miss the conversation we had with Habits Academy’s James Clear? Catch up by listening to episode 108: James Clear | Forming Atomic Habits for Astronomic Results! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

17 Marras 202254min

General Robert Spalding (@@robert_spalding) is a retired US Air Force brigadier general, the CEO of digital infrastructure company SEMPRE, and the author of Stealth War: How China Took Over While America’s Elite Slept and War Without Rules: China's Playbook for Global Domination. What We Discuss with General Robert Spalding: How a 1999 book by military strategists Qiao Liang and Wang Xiangsui called Unrestricted Warfare has become China's playbook for global domination against the Western world. Numerous ways the Chinese Communist Party (CCP) exploits Western weaknesses with this playbook's primary tenet: the best strategy for warfare is not to kill, but to control. Why the CCP isn't likely to crumble under the weight of its own debts as Soviet Russia did, and why a Chinese invasion of Taiwan stands a better chance of success than the Russian invasion of Ukraine. How the CCP uses corporate espionage, global pandemics, and trade violations to pursue its goal of dominance. What can we, as individuals clued in to the tactics of this playbook, do to resist the influence of the CCP on the Western world? And much more... Full show notes and resources can be found here: jordanharbinger.com/751 Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course! Miss our conversation with elite counterterrorism undercover agent Tamer Elnoury? Catch up with episode 572: Tamer Elnoury | Undercover with a Muslim FBI Agent here! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15 Marras 20221h 19min