#214 - Is fructose a driver of Alzheimer’s disease? | Dr. Richard Johnson & Dr. Rob Lustig

#214 - Is fructose a driver of Alzheimer’s disease? | Dr. Richard Johnson & Dr. Rob Lustig

Fructose and its byproduct uric acid may play a role in the development of Alzheimer’s, thanks to an evolutionary adaptation hijacked by the modern diet. Fructose can be directly consumed, or the body can convert high-glycemic carbohydrates and other foods to fructose. Fructose suppresses some cognitive functions. Dr. Richard Johnson and Dr. Rob Lustig discuss a new study, of which Johnson was an author, on how fructose may be a potential driver in Alzheimer’s, and they hypothesize about fructose’s potential connection to the development of other conditions.


Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl


🎙 What Richard Johnson, MD, & Rob Lustig, MD, discuss:

(09:50) — Fructose is the driver of some diseases that are on the rise in kids

(11:53) — Fructose is a driver of obesity and metabolic syndrome

(15:36) — Pharmaceutical treatments for Alzheimer’s disease aren’t as effective as researchers had hoped

(17:32)— The research focus of Alzheimer’s is slowly shifting to understanding insulin resistance in the brain

(20:41) — Is fructose a root cause of Alzheimer’s?

(26:26) — New research suggests fructose induces a foraging response

(28:20) — Fructose inhibits areas of the brain to encourage successful foraging

(46:48) — We need more research on fructose

(1:03:10) —Is fructose a factor in violence?


Transcripts & Show notes


Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health.


Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health.


👋 WHO WE ARE:

Levels helps you see how food affects your health. With real-time, personalized data gathered through biosensors like continuous glucose monitors (CGM), you learn which diet and lifestyle choices improve your metabolic health so you can live a longer, fuller, healthier life.


🔗 LINKS:

Could Alzheimer’s disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?: https://www.sciencedirect.com/science/article/abs/pii/S0002916523000047?dgcid=author

Subscribe here on YouTube: https://youtube.com/levelshealth?sub_confirmation=1


📲 CONNECT:

Connect with Richard Johnson, MD, on Instagram: https://www.instagram.com/drrichardjjohnson/

Connect with Robert Lustig, MD, on Instagram: https://www.instagram.com/robertlustigmd/

Jaksot(286)

#46 - Running a playbook for international expansion (Andy Schabelman & Ben Grynol)

#46 - Running a playbook for international expansion (Andy Schabelman & Ben Grynol)

Levels' Head of Growth, Ben Grynol, and Andy Schabelman, one of the first 30 employees at Airbnb who led their international expansion initiatives, sat down to discuss the nuances and complexities of scaling companies in new markets. Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. (3:11) - The grassroots growth of Airbnb (4:45) - Looking beyond transactional growth (10:08) - Tailing product to different cultures (11:59) - Go beyond localization (15:23) - Two methods of international growth (18:14) - Different countries need a unique order of operations (21:17) - Embrace a period of exploration (30:23) - Keep an open mind (32:07) - Learn from user behavior Transcripts & Show Notes

26 Marras 202135min

#45 - How to read a nutrition paper (Matt Laye & Mike Haney)

#45 - How to read a nutrition paper (Matt Laye & Mike Haney)

Mike Haney, Head of Content at Levels, sat down with Dr. Matt Laye, to discuss Matt's approach to deconstructing research based articles and what it means to actually digest a scientific based article.  Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. (8:19) - The importance of scientific literacy (11:29) - Determine the relevance of a study (13:00) - Identify the question the study is exploring (16:25) - Consider if the study is blind (19:17) - Controlled versus observational studies (22:21) - Take questionnaire data with a grain of salt (28:43) - Consider funding sources (34:21) - Take biases into account (47:34) - The meaning of statistical significance (54:17) - Studies provide a starting point for individual experimentation Transcripts & Show Notes

24 Marras 202156min

#44 - Creating engagement in a world of ever changing attention (Ali Spagnola & Ben Grynol)

#44 - Creating engagement in a world of ever changing attention (Ali Spagnola & Ben Grynol)

Levels Head of Growth, Ben Grynol, sat down with long-time Levels friend and content creator, Ali Spagnola, to discuss how she strikes a balance with her content in order to serve the ever-changing audiences and algorithms of social media. Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. (05:58) - What do you do when no diet works? (10:58) - The breakthrough moment with Levels (14:27) - Curating a list of 30 foods (18:39) - There's no recipe for health (24:52) - Let food take a backseat (27:34) - The freedom of food pairing (41:05) - Levels is (almost) a silver bullet (45:14) - Levels can teach something to everyone Transcripts & Show Notes

22 Marras 202150min

#43 - One CEO's 81 pound weight loss using a Levels CGM (Betsy McLaughlin & Casey Means)

#43 - One CEO's 81 pound weight loss using a Levels CGM (Betsy McLaughlin & Casey Means)

For 40 years, Betsy McLaughlin (former CEO of Hot Topic) worked out consistently and tried several diets—even bespoke nutrition programs—to change her metabolism and lose weight, but nothing worked. It all clicked when Betsy’s life coach and trainer introduced her to wearing a CGM through Levels. In this clip, Betsy shares her inspiring health journey and how Levels helped her understand what to eat and when to eat in order to optimize her metabolic health and see big changes quickly. Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. Blog post: https://www.levelshealth.com/blog/how-betsy-mclaughlin-changed-her-diet-and-lost-81-pounds-through-glucose-monitoring Transcript & Show Notes

18 Marras 202152min

#42 - Why remote and async teams should use Loom (Vinay Hiremath & Sam Corcos)

#42 - Why remote and async teams should use Loom (Vinay Hiremath & Sam Corcos)

Levels CEO, Sam Corcos, sat down with Vinay Hiremath, CEO of Loom, to discuss their outlook on remote and asynchronous communication and how Loom will benefit everyone in the workplace. Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. (07:51) - Meetings have an emotional appeal (09:30) - Tag people in (10:59) - Video is affective and temporal (23:33) - Assume positive intent (27:32) - Find creative ways to scale (33:14) - Make information discoverable (37:29) - Perfect is the enemy of done (59:21) - Overwriting the role of writing Transcripts & Show Notes

17 Marras 20211h 4min

#41 - The role of design in behavior change (Alan McLean & Ben Grynol)

#41 - The role of design in behavior change (Alan McLean & Ben Grynol)

Levels Head of Growth, Ben Grynol, sat down with Alan McLean, Head of Design at Levels, to discuss Alan's design philosophy, his approach to re-designing the Levels app, as well as his past experience with The New York Times, Fitbit and Google. Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. (07:27) - The importance of design for health products (09:40) - Generalists vs. specialists (10:19) - The value of technical expertise (12:33) - The value of constraints (19:00) - The print/digital divide (21:26) - Expectations are high for productivity tools (23:52) - Seek out magic moments (26:39) - Consider user context (28:55) - Focus on positive reinforcement (31:26) - Personalization is not a hack Transcripts & Show Notes

15 Marras 202148min

#40 - Stay off my operating table (Philip Ovadia & Casey Means)

#40 - Stay off my operating table (Philip Ovadia & Casey Means)

Levels' Chief Medical Officer, Dr. Casey Means, sat down with Dr. Philip Ovadia to discuss the key factors that lead to poor metabolic health. As well, they discussed their views on how to solve the metabolic crisis, and Dr. Ovadia's new book, "Stay Off My Operating Table." Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. (04:42) - Medicine will not fix metabolic health (14:32) - The benefit of continuous glucose monitors (17:14) - Why are CGMs not in hospitals? (20:49) - Eat whole foods (23:53) - It's time to talk about what we eat (26:01) -Take one step at a time (28:03) - Substitute, don't eliminate (30:29) - Read your food labels (51:19) - Don't rely on exercise alone (01:00:34) - Pay attention to the metrics of metabolic health Transcripts & Show Notes

11 Marras 20211h 14min

#39 - The Levels cultural handbook (Sam Corcos & Josh Clemente)

#39 - The Levels cultural handbook (Sam Corcos & Josh Clemente)

Sam Corcos, CEO of Levels, and Josh Clemente, Founder of Levels, sat down to discuss their outlook on a cultural handbook which was created by Miz, Head of Operations at Levels. The handbook dives into the values at Levels, and how to effectively build culture in an asynchronous and remote team. Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. (05:51) - Avoid paternalistic rules (08:22) - Companies must create structure from chaos (11:19) - Foster a productive environment (18:57) - Make decisions for the good of the organization (28:02) - Leave personal lives in the control of employees (31:59) - The definition of project debt (37:24) - Maintain a tolerance for risk (39:27) - Don't Be a Blocker (48:57) - The role of constructive criticism (59:53) - Take action instead of complaining Transcripts & Show Notes

9 Marras 20211h 5min

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