#225: John Crowley -- The Real-Life Captain America and Bruce Banner (Seriously)

#225: John Crowley -- The Real-Life Captain America and Bruce Banner (Seriously)

John F. Crowley is the Chairman and CEO of Amicus Therapeutics, a publicly traded biotechnology company, which he helped to found in 2005 and is now a 300+ person company in 22 countries. John's involvement with biotechnology stems from the 1998 diagnosis of two of his children with Pompe disease -- a severe and often fatal neuromuscular disorder. In his drive to find a cure for them, he left his job and became an entrepreneur as the Co-founder, President, and CEO of Novazyme Pharmaceuticals in 2000, a biotech start-up conducting research on a new experimental treatment for Pompe disease (which he credits as ultimately saving his children's lives). In 2001, Novazyme was acquired by Genzyme Corporation for nearly $200 million. John and his family have been profiled on the front page of The Wall Street Journal and are the subjects of a book by Pulitzer prize-winning journalist Geeta Anand, The Cure: How a Father Raised $100 Million -- and Bucked the Medical Establishment -- in a Quest to Save His Children. The major motion picture Extraordinary Measures, starring Brendan Fraser and Harrison Ford, is inspired by the Crowley family journey. John is the author of a personal memoir: Chasing Miracles: The Crowley Family Journey of Strength, Hope, and Joy. John also served as a commissioned intelligence officer in the U.S. Navy Reserve from 2005-2016. He was assigned to the Joint Special Operations Command (JSOC) and is a veteran of the global war on terrorism, with service in Afghanistan. He graduated with a B.S. in Foreign Service from Georgetown University, and earned a J.D. from the University of Notre Dame Law School and an M.B.A. from Harvard. He previously served (2014-2016) as the National Chairman of the Make-A-Wish Foundation of America and is a founding board member of the Global Genes Project. John is a Henry Crown Fellow at The Aspen Institute. This is an incredibly powerful episode. Enjoy! Show notes and links for this episode can be found at www.fourhourworkweek.com/podcast. This podcast is brought to you by iD Commerce + Logistics. I'm asked all the time about how to scale businesses quickly. Rule number one: remove unnecessary bottlenecks. Many businesses can do so by outsourcing inventory management and fulfillment to a company that makes this its primary focus. iD Commerce + Logistics is just such a company. It helps online retailers and entrepreneurs outgrow their competition by handling all types of details -- from inventory to packing and shipping. I depended on iD to handle these types of details when I launched The 4-Hour Chef so I could focus on promoting the book. As a listener of this podcast, you can get up to $10,000 off your start-up fees and costs waived by visiting tim.blog/scale or idcomlog.com/tim. This podcast is also brought to you by Wealthfront. Wealthfront is a massively disruptive (in a good way) set-it-and-forget-it investing service, led by technologists from places like Apple and world-famous investors. It has exploded in popularity in the last two years and now has more than $2.5B under management. In fact, some of my good investor friends in Silicon Valley have millions of their own money in Wealthfront. Why? Because you can get services previously limited to the ultra-wealthy and only pay pennies on the dollar for them, and it's all through smarter software instead of retail locations and bloated sales teams. Check out wealthfront.com/tim, take their risk assessment quiz, which only takes 2-5 minutes, and they'll show you -- for free -- exactly the portfolio they'd put you in. If you want to just take their advice and do it yourself, you can. Or, as I would, you can set it and forget it. Well worth a few minutes: wealthfront.com/tim.

***

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#847: Steve Young, from Super Bowl MVP to Managing Billions – Hall of Fame 49ers Quarterback on High Performance, Reinvention, Faith, and How to Blend Dreams and Plans

#847: Steve Young, from Super Bowl MVP to Managing Billions – Hall of Fame 49ers Quarterback on High Performance, Reinvention, Faith, and How to Blend Dreams and Plans

Steve Young (@steveyoung) is a Hall of Fame NFL quarterback who played more than 15 seasons, primarily with the San Francisco 49ers. Steve co-founded HGGC, which manages more than $6.9B in capital com...

14 Tammi 1h 49min

#846: Permission to Do Nothing — Guided Meditation with Zen Master Henry Shukman

#846: Permission to Do Nothing — Guided Meditation with Zen Master Henry Shukman

This episode is part of a series called Meditation Monday. The teacher, Henry Shukman, has been on my podcast twice before. He is one of only a few dozen masters in the world authorized to teach Sanbo...

12 Tammi 9min

#845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment)

#845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment)

Dr. Dominic D’Agostino (@DominicDAgosti2) is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and...

7 Tammi 2h 21min

#844: Be Still — Guided Meditation with Zen Master Henry Shukman

#844: Be Still — Guided Meditation with Zen Master Henry Shukman

This episode is part of a series called Meditation Monday. The teacher, Henry Shukman, has been on my podcast twice before. He is one of only a few dozen masters in the world authorized to teach Sanbo...

5 Tammi 8min

#843: Tactics and Strategies for a 2026 Reboot — Essentialism and Greg McKeown (Repost)

#843: Tactics and Strategies for a 2026 Reboot — Essentialism and Greg McKeown (Repost)

Greg McKeown is the author of two New York Times bestsellers, Essentialism: The Disciplined Pursuit of Less and Effortless: Make It Easier to Do What Matters Most. 200,000 people receive his weekly 1-...

1 Tammi 1h 47min

#842: The Story Behind EpiPen, The Rise of Food Allergies, and What Doctors Got Wrong

#842: The Story Behind EpiPen, The Rise of Food Allergies, and What Doctors Got Wrong

This time around, we have an experimental format, featuring the first episode of a brand-new podcast launching next week, Drug Story. I rarely feature episodes from other shows, but I think this one i...

30 Joulu 202558min

#841: Arthur Brooks — Finding The Meaning of Your Life, The Poet's Protocol, The Holy Half-Hour, and Why Your Suffering is Sacred

#841: Arthur Brooks — Finding The Meaning of Your Life, The Poet's Protocol, The Holy Half-Hour, and Why Your Suffering is Sacred

Arthur C. Brooks is a professor at the Harvard Kennedy School and the Harvard Business School, where he teaches courses on leadership and happiness. His next book, The Meaning of Your Life: Finding Pu...

23 Joulu 20252h 10min

#840: Bill Gurley — Investing in The AI Era, 10 Days in China, and Important Life Lessons from Bob Dylan, Jerry Seinfeld, MrBeast, and More

#840: Bill Gurley — Investing in The AI Era, 10 Days in China, and Important Life Lessons from Bob Dylan, Jerry Seinfeld, MrBeast, and More

Bill Gurley (@bgurley) is a general partner at Benchmark, a leading venture capital firm in Silicon Valley. His new book is Runnin’ Down a Dream: How to Thrive in a Career You Actually Love.This episo...

17 Joulu 20252h 10min

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