#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer

#117: Dom D'Agostino on Fasting, Ketosis, and The End of Cancer

Dr. Dominic “Dom" D’Agostino (@DominicDAgosti2) is an Assistant Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine, and a Senior Research Scientist at the Institute for Human and Machine Cognition (IHMC). He has also deadlifted 500 pounds for 10 reps after a seven-day fast. He’s a beast and — no big surprise — he’s a good buddy of Dr. Peter Attia, my MD friend who drinks "jet fuel" in search of optimal athletic performance. The primary focus of Dom's laboratory is developing and testing metabolic therapies, including ketogenic diets, ketone esters and ketone supplements to induce nutritional/therapeutic ketosis. D’Agostino’s laboratory uses in vivo and in vitro techniques to understand the physiological, cellular and molecular mechanism of metabolic therapies and nutritional strategies for peak performance and resilience. His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and foundations. Show notes and links for this episode can be found at www.fourhourworkweek.com/podcast. This podcast is brought to you by Audible. I have used Audible for years and I love audio books. I have 2 to recommend: The Graveyard Book by Niel Gaiman Vagabonding by Rolf Potts All you need to do to get your free audiobook and a free 30-day trial is go to Audible.com/tim. Choose one of the above books, or choose between more than 180,000 audio programs. That could be a book, a newspaper, a magazine or even a class. It's that easy. Go to Audible.com/Tim and get started today. Enjoy! This podcast is also brought to you by 99Designs, the world’s largest marketplace of graphic designers. I have used them for years to create some amazing designs. When your business needs a logo, website design, business card, or anything you can imagine, check out 99Designs. I used them to rapid prototype the cover for The 4-Hour Body, and I've also had them help with display advertising and illustrations. If you want a more personalized approach, I recommend their 1-on-1 service, which is non-spec. You get original designs from designers around the world. The best part? You provide your feedback, and then you end up with a product that you're happy with or your money back. Click this link and get a free $99 upgrade. Give it a test run… Enjoy!

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Jaksot(867)

#863: Elad Gil, Consigliere to Empire Builders — How to Spot Billion-Dollar Companies Before Everyone Else, The Misty AI Frontier, How Coke Beat Pepsi, When Consensus Pays, and Much More

#863: Elad Gil, Consigliere to Empire Builders — How to Spot Billion-Dollar Companies Before Everyone Else, The Misty AI Frontier, How Coke Beat Pepsi, When Consensus Pays, and Much More

Elad Gil (@eladgil) is CEO of Gil & Co, a multi-stage investment firm, holding company, and operating company working on the world’s most advanced technologies. Elad is a serial entrepreneur, operatin...

29 Huhti 1h 51min

#862: Cathy Lanier, Chief Security Officer of the NFL — From 9th-Grade Dropout to DC's Longest-Serving Police Chief, Protecting the Super Bowl, and Resilience Under Extreme Pressure

#862: Cathy Lanier, Chief Security Officer of the NFL — From 9th-Grade Dropout to DC's Longest-Serving Police Chief, Protecting the Super Bowl, and Resilience Under Extreme Pressure

Cathy Lanier is the Chief Security Officer of the National Football League, where she oversees security across the league office and all 32 clubs. Before the NFL, she served as Chief of Police of Wash...

23 Huhti 1h 35min

#861: 4-Hour Workweek Success Story Brian Dean — From Dad’s Basement to Selling Two Companies

#861: 4-Hour Workweek Success Story Brian Dean — From Dad’s Basement to Selling Two Companies

Brian Dean is the founder of Backlinko and Exploding Topics, both acquired by Semrush, which itself was recently acquired by Adobe for $1.9 billion. Brian's story starts exactly where a lot of great s...

16 Huhti 1h 2min

#860: Daredevil Michelle Khare — How to Become a YouTube Superstar, Open Impossible Doors (FBI, Secret Service, etc.), Craft Jedi-Level Cold Emails, and Use Fear-Setting to Change Your Life

#860: Daredevil Michelle Khare — How to Become a YouTube Superstar, Open Impossible Doors (FBI, Secret Service, etc.), Craft Jedi-Level Cold Emails, and Use Fear-Setting to Change Your Life

Daredevil Michelle Khare lives life to the extreme in Challenge Accepted, amassing more than 6 million followers and more than 1 billion views. Across the show, you'll see Michelle attempt everything ...

7 Huhti 3h 10min

#859: Q&A with Tim — The Upcoming AI Tsunami and Building Offline Advantage, Book Recommendations, Spotting Psychedelic Red Flags, Courage as a Learnable Skill, and More

#859: Q&A with Tim — The Upcoming AI Tsunami and Building Offline Advantage, Book Recommendations, Spotting Psychedelic Red Flags, Courage as a Learnable Skill, and More

Welcome back to another in-between-isode, with one of my favorite formats: the good old-fashioned Q&A.This episode is brought to you by:Our Place’s Titanium Always Pan® Pro using nonstick technology t...

26 Maalis 1h 23min

#858: The Random Show, Couch Edition! — Supplements, Hummingbirds, Cock Rings, Optimizing Mitochondria, Breathing and Balance Training, Cool Grip Strength Tools, and More

#858: The Random Show, Couch Edition! — Supplements, Hummingbirds, Cock Rings, Optimizing Mitochondria, Breathing and Balance Training, Cool Grip Strength Tools, and More

Welcome to another wide-ranging "Random Show" episode that I recorded with my close friend Kevin Rose (digg.com)!This episode is brought to you by:Eight Sleep Pod Cover 5 sleeping solution for dynamic...

18 Maalis 1h 36min

#857: How to Simplify Your Life in 2026 — New Tips from Maria Popova, Morgan Housel, Cal Newport, Craig Mod, and Debbie Millman

#857: How to Simplify Your Life in 2026 — New Tips from Maria Popova, Morgan Housel, Cal Newport, Craig Mod, and Debbie Millman

Many of us feel like we’re drowning in invisible complexity. So I wanted to hit pause and ask a simple question: What are 1-3 decisions that could dramatically simplify my life in 2026? To explore tha...

10 Maalis 42min

#856: Jim Collins — What to Make of a Life and How to Maximize Your Return on Luck

#856: Jim Collins — What to Make of a Life and How to Maximize Your Return on Luck

Jim Collins has published multiple international bestsellers that have sold in total more than eleven million copies worldwide, including the perennial favorite Good to Great. His new book is What to ...

5 Maalis 2h 49min

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