#104: Are Psychedelic Drugs the Next Medical Breakthrough?

#104: Are Psychedelic Drugs the Next Medical Breakthrough?

Martin Polanco (@Martin_Polanco7), M.D., is the founder and program director of Crossroads Treatment Center, based in Rosarito, Mexico. Crossroads specializes in helping patients conquer powerful addictions (heroin, cocaine, etc.) by using the African hallucinogen ibogaine and 5-MeO-DMT, also referred to as “the God molecule.” Martin's areas of expertise also include addiction medicine and therapeutic neurotechnologies. Dan Engle (@drdanengle), M.D., is a psychiatrist and neurologist, who combines functional medicine with integrative psychiatry to enhance regenerative health and peak performance. His prior and relevant experience includes traumatic brain injury (TBI) and working in the Peruvian jungle with plant medicines such as ayahuasca. In this episode, we step outside the lines of traditional medicine to discuss impulse control, introspection, and self-awareness through the use of powerful psychedelic and hallucinogenic agents like iboga, ibogaine and 5-MeO-DMT. We also discuss flotation tanks, which can simulate or even replicate many of the benefits that can result from the use of psychedelic and psychotropic agents. So you don't have to be willing to experiment with these medicines to receive something valuable from this episode. If you are interested in optimizing your psychological performance, emotional control and exploring alternative medicine, then this episode is for you. Enjoy! Show notes and links for this episode can be found at www.fourhourworkweek.com/podcast. This podcast is brought to you by TrunkClub. I hate shopping with a passion. And honestly I’m not good at it, which means I end up looking like I'm colorblind or homeless. Enter TrunkClub, which provides you with your own personal stylist and makes it easier than ever to shop for clothes that look great on your body. Just go to trunkclub.com/tim and answer a few questions, and then you'll be sent a trunk full of awesome clothes. They base this on your sizes, preferences, etc. The trunk is then delivered free of charge both ways, so you only pay for clothes that you keep. If you keep none, it costs you nothing. To get started, check it out at trunkclub.com/tim. This podcast is also brought to you by Vimeo Pro, which is the ideal video hosting platform for entrepreneurs. In fact, a bunch of my start-ups are already using Vimeo Pro. WealthFront uses it to explain how WealthFront works. TaskRabbit uses it to tell the company’s story. There are many other names who you would recognize among their customers (AirBnB, Etsy, etc.) Why do they use it? Vimeo Pro provides enterprise level video hosting for a fraction of the usual cost. Features include: Gorgeous high-quality playback with no ads Up to 20 GB of video storage every week Unlimited plays and views A fully customizable video player, which can include your company logo, custom outro, and more You get all this for just $199 per year (that’s only $17 per/mo.). There are no complicated bandwidth calculations or hidden fees. Try it risk-free for 30 days. Just go to Vimeo.com/business to check it out. If you like it, you can use the promo code “Tim” to get 25% off. This is a special discount just for you guys.

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#839: Dr. Fei-Fei Li, The Godmother of AI — Asking Audacious Questions, Civilizational Technology, and Finding Your North Star

#839: Dr. Fei-Fei Li, The Godmother of AI — Asking Audacious Questions, Civilizational Technology, and Finding Your North Star

Dr. Fei-Fei Li (@drfeifei) is the inaugural Sequoia Professor in the Computer Science Department at Stanford University, a founding co-director of Stanford’s Human-Centered AI Institute, and the co-fo...

9 Joulu 20251h 18min

#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello

#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello

Welcome to another wide-ranging "Random Show" episode that I recorded with my close friend Kevin Rose (digg.com)!This episode is brought to you by:Qlosi prescription eye drop used to treat age-related...

3 Joulu 20251h 51min

#837: How to Simplify Your Life in 2026 — New Tips from Derek Sivers, Seth Godin, and Martha Beck

#837: How to Simplify Your Life in 2026 — New Tips from Derek Sivers, Seth Godin, and Martha Beck

As we head into the new year, many of us feel like we’re drowning in invisible complexity. So I wanted to hit pause and ask a simple question: What are 1-3 decisions that could dramatically simplify m...

26 Marras 202532min

#836: The 4-Hour Workweek Principles — 13 Mistakes to Avoid, The Art of Mini-Retirements, and Navigating the Dizziness of Freedom

#836: The 4-Hour Workweek Principles — 13 Mistakes to Avoid, The Art of Mini-Retirements, and Navigating the Dizziness of Freedom

This time around, we have a bit of a different format, featuring the book that started it all for me, The 4-Hour Workweek. Readers and listeners often ask me what I would change or update, but an equa...

19 Marras 20251h 37min

#835: Ben Patrick (KneesOverToesGuy) — 20-Minute Workouts That Produce Wild Results, From Chronic Knee Pain to Dunking Basketballs, Lessons from Charles Poliquin, Bulletproofing the Lower Body, and More

#835: Ben Patrick (KneesOverToesGuy) — 20-Minute Workouts That Produce Wild Results, From Chronic Knee Pain to Dunking Basketballs, Lessons from Charles Poliquin, Bulletproofing the Lower Body, and More

Ben Patrick, better known as “Kneesovertoesguy” (@kneesovertoesguy), is the founder of Athletic Truth Group (ATG), an online and brick-and-mortar training system rooted in rehabilitative strength and ...

12 Marras 20251h 37min

#834: David Baszucki, Co-Founder of Roblox — The Path to 150M+ Daily Users, Critical Business Decisions, Ketogenic Therapy for Brain Health, Daily Routines, The Roblox Economy, and More

#834: David Baszucki, Co-Founder of Roblox — The Path to 150M+ Daily Users, Critical Business Decisions, Ketogenic Therapy for Brain Health, Daily Routines, The Roblox Economy, and More

David Baszucki is the founder and CEO of Roblox. TIME named Roblox one of the “100 Most Influential Companies,” and it has been recognized by Fast Company for innovation on their “Most Innovative Comp...

5 Marras 20251h 55min

#833: Jack Canfield — Selling 600+ Million Books, Success Principles, and How He Made The 4-Hour Workweek Happen

#833: Jack Canfield — Selling 600+ Million Books, Success Principles, and How He Made The 4-Hour Workweek Happen

Jack Canfield is the coauthor of more than two hundred books, including, The Success Principles™: How to Get from Where You Are to Where You Want to Be and the Chicken Soup for the Soul® series, which...

29 Loka 20251h 37min

#832: The Return of The Lion Tracker — Boyd Varty on The Wild Man Within, Nature’s Hidden Wisdom, and How to Feel Fully Alive

#832: The Return of The Lion Tracker — Boyd Varty on The Wild Man Within, Nature’s Hidden Wisdom, and How to Feel Fully Alive

Boyd Varty is the founder of Track Your Life, which offers a limited number of premium retreats in South Africa’s bushveld, and author of one of my favorite books, The Lion Tracker’s Guide to Life. As...

22 Loka 20252h 2min

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