ALLG AMLM16: Does sorafenib plus intensive chemotherapy improve outcome in FLT3-ITD AML?
AML Hub2 Helmi 2021

ALLG AMLM16: Does sorafenib plus intensive chemotherapy improve outcome in FLT3-ITD AML?

During the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, the AML Hub spoke to Andrew Wei, The Alfred Hospital, Melbourne, AU, and Natasha S. Anstee, The Alfred Hospital & Monash University, Melbourne, AU. We asked, Does sorafenib plus intensive chemotherapy improve outcome in FLT3-internal tandem duplication (FLT3-ITD) AML?


Wei starts by introducing the clinical study data from AMLM16, a randomized, placebo-controlled trial evaluating sorafenib versus placebo in combination with intensive chemotherapy for previously untreated adult patients with FLT3-ITD AML. In this study, sorafenib did not improve event-free survival when combined with intensive chemotherapy; Wei discusses the possible causes of this result and the subgroups that did better in the sorafenib arm. Anstee then reports the results from the correlative studies evaluating the impact of sorafenib on phospho-FLT3 inhibition and the presence of FLT3-ITD measurable residual disease after chemotherapy.

Hosted on Acast. See acast.com/privacy for more information.

Tämä jakso on lisätty Podme-palveluun avoimen RSS-syötteen kautta eikä se ole Podmen omaa tuotantoa. Siksi jakso saattaa sisältää mainontaa.

Jaksot(40)

Menin inhibitors in AML: Where are we now, and where are we going?

Menin inhibitors in AML: Where are we now, and where are we going?

During a meeting of the AML Hub Steering Committee, held on February 19, 2026, Jorge Cortes chaired a discussion on the topic, Menin inhibitors in AML: Where are we now, and where are we going? The di...

22 Touko 30min

Managing side effects of menin inhibitors in clinical practice

Managing side effects of menin inhibitors in clinical practice

The AML Hub was pleased to speak with Gail Roboz, Weill Cornell Medicine, New York, US. We asked, What side effects are typically observed with menin inhibitor-based regimens, and how do you approach ...

21 Touko 7min

 Mechanisms and rationale for menin inhibitor combination strategies in AML

Mechanisms and rationale for menin inhibitor combination strategies in AML

The AML Hub was pleased to speak with Eunice Wang from Roswell Park Comprehensive Cancer Center, Buffalo, US. We asked, What are the mechanisms and rationale for menin inhibitor combination strategies...

20 Touko 4min

Treatment decisions in AML: Personalizing care with FLT3 inhibitor therapy

Treatment decisions in AML: Personalizing care with FLT3 inhibitor therapy

During a meeting of the AML Hub Steering Committee, held on February 19, 2026, Jorge Sierra chaired a discussion on the topic, Treatment decisions in acute myeloid leukemia (AML): Personalizing care w...

19 Touko 32min

What key insights are emerging from ongoing trials of menin inhibitor combination strategies in AML?

What key insights are emerging from ongoing trials of menin inhibitor combination strategies in AML?

The AML Hub was pleased to speak with Joshua Zeidner, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, US. We asked, What key insights are emerging from ongoing trials...

15 Touko 5min

Symposium | Understanding the differences between FLT3-ITD and -TKD mutations in AML: Q&A

Symposium | Understanding the differences between FLT3-ITD and -TKD mutations in AML: Q&A

The AML Hub held a virtual symposium on November 19, 2025, titled Understanding the differences between FLT3-ITD and -TKD mutations in AML: Implications for clinical practice. The symposium ended with...

12 Helmi 7min

Symposium | Implications for clinical practice: Managing AML with FLT3-ITD and -TKD mutations

Symposium | Implications for clinical practice: Managing AML with FLT3-ITD and -TKD mutations

The AML Hub held a virtual symposium on November 19, 2025, titled Understanding the differences between FLT3-ITD and -TKD mutations in AML: Implications for clinical practice. Here, we share a present...

11 Helmi 14min

Symposium | Comparing treatment options for patients with FLT3-ITD and -TKD mutations

Symposium | Comparing treatment options for patients with FLT3-ITD and -TKD mutations

The AML Hub held a webinar on November 19, 2025, titled, Understanding the differences between FLT3-ITD and -TKD mutations in AML: Implications for clinical practice. Here, we share a presentation fro...

19 Tammi 20min

Suosittua kategoriassa Koulutus

rss-murhan-anatomia
psykopodiaa-podcast
voi-hyvin-meditaatiot-2
rss-rahamania
adhd-podi
kesken
rss-liian-kuuma-peruna
rss-laadukasta-ensihoitoa
rss-vapaudu-voimaasi
psykologia
rss-narsisti
rss-niinku-asia-on
rss-valo-minussa-2
rss-arkea-ja-aurinkoa-podcast-espanjasta
rss-hereilla
rahapuhetta
aamukahvilla
ihminen-tavattavissa-tommy-hellsten-instituutti
rss-keho-mieli-ja-tekoaly-2
rss-tfa-8020-podcast