Scepticaemia - helping find meaning in science

We meet Paul Garner (prof. emerit. and one of the founding fathers of Cochrane) and Rebecca Kuehn (Cochrane infectious diseases) for a talk about evidence-based medicine, critical appraisal and all things related to how we interpret and find the "truth" within research.

Resources:

1.Ioannidis JP. Why most published research findings are false. PLoS Med. 2005;2(8):e124.

2.Garner P, Taylor-Robinson D, Sachdev HS. DEVTA: results from the biggest clinical trial ever. Lancet. 2013;381(9876):1439-41.

3.Gigerenzer G. Making sense of health statistics. Bull World Health Organ. 2009;87(8):567.

4.https://www.badscience.net/2010/07/yeah-well-you-can-prove-anything-with-science/

5.de Souza DK, Thomas R, Bradley J, Leyrat C, Boakye DA, Okebe J. Ivermectin treatment in humans for reducing malaria transmission. Cochrane Database Syst Rev. 2021;6(6):CD013117.

6.Foy BD, Alout H, Seaman JA, Rao S, Magalhaes T, Wade M, et al. Efficacy and risk of harms of repeat ivermectin mass drug administrations for control of malaria (RIMDAMAL): a cluster-randomised trial. Lancet. 2019;393(10180):1517-26.

7.Popp M, Reis S, Schiesser S, Hausinger RI, Stegemann M, Metzendorf MI, et al. Ivermectin for preventing and treating COVID-19. Cochrane Database Syst Rev. 2022;6(6):CD015017.

8.Hadinegoro SR, Arredondo-Garcia JL, Capeding MR, Deseda C, Chotpitayasunondh T, Dietze R, et al. Efficacy and Long-Term Safety of a Dengue Vaccine in Regions of Endemic Disease. N Engl J Med. 2015;373(13):1195-206.

9.Dans AL, Dans LF, Lansang MAD, Silvestre MAA, Guyatt GH. Controversy and debate on dengue vaccine series-paper 1: review of a licensed dengue vaccine: inappropriate subgroup analyses and selective reporting may cause harm in mass vaccination programs. J Clin Epidemiol. 2018;95:137-9.

10. Guyatt G, Oxman AD, Akl EA, Kunz R, Vist G, Brozek J, et al. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol. 2011;64(4):383-94.

11. https://bestpractice.bmj.com/info/toolkit/learn-ebm/what-is-grade/

12.Guyatt G, Vist G, Falck-Ytter Y, Kunz R, Magrini N, Schunemann H. An emerging consensus on grading recommendations? ACP J Club. 2006;144(1):A8-9.

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