Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

At supraphysiological dosages, taking GH before going to sleep makes sense because there is a negative feedback loop on the growth hormone (GH)/insulin-like growth factor I (IGF-1) axis. In this study, IGF-1 was constantly infused, and the effect on endogenous GH secretion was assessed [R]. Overall, GH concentrations were suppressed during the rhIGF-I infusion by 85±3%, mainly by attenuating spontaneous GH pulse amplitude (77±4% suppression). The apparent GH pulse frequency was attenuated from 7.8±0.9 to 4.7±0.6 pulses/24h (P= 0.006). IGF-1 is the primary feedback, and the mechanism is similar to what you see with the HPTA axis. When there is enough Testosterone and Estrogen, your body has this mechanism in place to prevent you from making more. The same thing happens with exogenous GH use. When you administer exogenous GH, IGF-1 elevates. When your body recognizes that IGF-1 is elevated, it starts to suppress GH pulse amplitude in a dose dependent manner. If you are using supraphysiological amounts of GH for bodybuilding purposes, you can assume that your natural secretion is greatly inhibited during sleep as this negative feedback loop will prevent your body from secreting GH in your sleep like it normally would. When endogenous GH production is suppressed, administering exogenous GH at times that lipolysis or muscle growth can be optimized is the most logical approach to injection timing. https://youtu.be/8j9MGfQPeXg If fat loss is the goal, then taking GH in a fasted state prior to fasted cardio would be ideal. There is a ceiling on how much GH is needed to maximize lipolysis, so if your dosage exceeds 2 IU per day, then I would advise splitting up that dose into two (or more if needed) different periods of the day with as much time between them as possible. If muscle growth is the goal, GH should still be administered in a pulsatile fashion to mimic endogenous secretions. Topped out stimulation of autocrine IGF-1 in skeletal muscle can be achieved with fairly low dosages of exogenous GH, and administering a higher dose above and beyond that may just be a waste. This is why it would be wise to split up your daily GH dose into multiple administrations if you are using supraphysiological dosages. Learn more about your ad choices. Visit megaphone.fm/adchoices

Jaksot(1361)

DHB (Dihydroboldenone) | The Most Overhyped and Liver Toxic Injectable Steroid?

DHB (Dihydroboldenone) | The Most Overhyped and Liver Toxic Injectable Steroid?

DHB, also known as Dihydroboldenone or 1-Testosterone, has gotten a lot of hype in the past few years in the bodybuilding community. Guys are always looking for the new exotic steroid to try. It's almost like a form of shiny object syndrome.… Learn more about your ad choices. Visit megaphone.fm/adchoices

4 Syys 20194min

The REAL Half-Life Of S4 (Andarine) | It Is NOT Four Hours

The REAL Half-Life Of S4 (Andarine) | It Is NOT Four Hours

A common misconception about the Selective Androgen Receptor Modulator (SARM) S4 , also known as Andarine, is its half-life. The Human Equivalent Half-Life Of S4 In Preclinical Studies The preclinical data states that the half-life of S4 is only 4 hours in humans [R].… Learn more about your ad choices. Visit megaphone.fm/adchoices

30 Elo 20193min

How To Test For Hypothyroidism With A Thermometer | Temperature As A Reference Of Thyroid Health

How To Test For Hypothyroidism With A Thermometer | Temperature As A Reference Of Thyroid Health

Are you constantly tired, even when you’re well rested and haven't engaged in excessive amounts of strenuous activities? Do you have major brain fog, or perhaps even constantly feel cold, even in the summer? You know you are trying to stay healthy, but still feel constantly run down.… Learn more about your ad choices. Visit megaphone.fm/adchoices

29 Elo 20194min

Fast Drying, Non Greasy Minoxidil And The Best Ketoconazole Shampoo For Hair Loss

Fast Drying, Non Greasy Minoxidil And The Best Ketoconazole Shampoo For Hair Loss

Regenepure Reached Out To Me The owner of Regenepure personally reached out to me recently and expressed his gratitude for my posts I've made in the past where I spoke highly of their Ketoconazole shampoo. To this day, Regenepure DR is still the first thing I tell people to use if they're starting a hair loss prevention regimen because it's over-the-counter, the risk profile is very low, and there's an extremely low incidence of side effects.… Learn more about your ad choices. Visit megaphone.fm/adchoices

19 Elo 201924min

Reacting To And Analyzing Dennis Newman’s Steroid Cycle In The 90’s

Reacting To And Analyzing Dennis Newman’s Steroid Cycle In The 90’s

This interview discussing Dennis Newman's steroid cycle was recorded by Tom Platz in the 90's. There is some speculation as to whether this was Mike Matarazzo or Dennis Newman in the interview. Some even thought it was Bob Ciccarello. The consensus is that this is more than likely Dennis Newman, but we don't know for certain as this interview was meant to be anonymous after all.… Learn more about your ad choices. Visit megaphone.fm/adchoices

18 Elo 201945min

Reacting To And Analyzing Chris Cormier’s Steroid Cycle In The 90’s

Reacting To And Analyzing Chris Cormier’s Steroid Cycle In The 90’s

This interview discussing Chris Cormier's steroid cycle was recorded by Tom Platz in the 90's. The guys that can best shed light on exactly what happened in the bodybuilding community in the 90's are the same guys who've been at the Olympia level and have Olympia caliber physiques.… Learn more about your ad choices. Visit megaphone.fm/adchoices

17 Elo 20191h 12min

When Bodybuilders Retire… | Before And After Pictures

When Bodybuilders Retire… | Before And After Pictures

Videos are posted to YouTube all the time highlighting the shocking regression bodybuilders physiques undergo after they retire from competing. Rather than focus on the deterioration of their physiques, I prefer to look at the situation in a more positive light.… Learn more about your ad choices. Visit megaphone.fm/adchoices

15 Elo 20198min

Should You Weigh Your Meat Cooked Or Uncooked? | HUGE Macros Mistake

Should You Weigh Your Meat Cooked Or Uncooked? | HUGE Macros Mistake

Weigh your meat raw, and then weigh that same amount cooked so you know exactly how much it is being dehydrated during the cooking process. A big mistake I see people make all the time when calculating their macros is they weigh their meat cooked without factoring in the uncooked weight.… Learn more about your ad choices. Visit megaphone.fm/adchoices

15 Elo 20192min

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