Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

At supraphysiological dosages, taking GH before going to sleep makes sense because there is a negative feedback loop on the growth hormone (GH)/insulin-like growth factor I (IGF-1) axis. In this study, IGF-1 was constantly infused, and the effect on endogenous GH secretion was assessed [R]. Overall, GH concentrations were suppressed during the rhIGF-I infusion by 85±3%, mainly by attenuating spontaneous GH pulse amplitude (77±4% suppression). The apparent GH pulse frequency was attenuated from 7.8±0.9 to 4.7±0.6 pulses/24h (P= 0.006). IGF-1 is the primary feedback, and the mechanism is similar to what you see with the HPTA axis. When there is enough Testosterone and Estrogen, your body has this mechanism in place to prevent you from making more. The same thing happens with exogenous GH use. When you administer exogenous GH, IGF-1 elevates. When your body recognizes that IGF-1 is elevated, it starts to suppress GH pulse amplitude in a dose dependent manner. If you are using supraphysiological amounts of GH for bodybuilding purposes, you can assume that your natural secretion is greatly inhibited during sleep as this negative feedback loop will prevent your body from secreting GH in your sleep like it normally would. When endogenous GH production is suppressed, administering exogenous GH at times that lipolysis or muscle growth can be optimized is the most logical approach to injection timing. https://youtu.be/8j9MGfQPeXg If fat loss is the goal, then taking GH in a fasted state prior to fasted cardio would be ideal. There is a ceiling on how much GH is needed to maximize lipolysis, so if your dosage exceeds 2 IU per day, then I would advise splitting up that dose into two (or more if needed) different periods of the day with as much time between them as possible. If muscle growth is the goal, GH should still be administered in a pulsatile fashion to mimic endogenous secretions. Topped out stimulation of autocrine IGF-1 in skeletal muscle can be achieved with fairly low dosages of exogenous GH, and administering a higher dose above and beyond that may just be a waste. This is why it would be wise to split up your daily GH dose into multiple administrations if you are using supraphysiological dosages. Learn more about your ad choices. Visit megaphone.fm/adchoices

Jaksot(1360)

Why More Body Hair Growth Means More Hair Loss On Your Head

Why More Body Hair Growth Means More Hair Loss On Your Head

More Body Hair Growth Equates To More Hair Loss There's a huge misconception about how androgens affect hair growth. A lot of guys truly believe that androgenic hormones improve scalp hair growth because “more body hair growth” is a listed side effect.… Learn more about your ad choices. Visit megaphone.fm/adchoices

26 Touko 20193min

Do You Need To Be Sore After Working Out To Gain Muscle?

Do You Need To Be Sore After Working Out To Gain Muscle?

How Sore You Were When You First Started Working Out Vs Now When you first start working out as a newbie you'll notice after 24 to 48 hours you are absurdly sore. When a new type of stimulus/resistance is exerted upon your body you will inevitably experience “delayed onset muscle soreness” (DOMS), which is completely normal and expected.… Learn more about your ad choices. Visit megaphone.fm/adchoices

25 Touko 20193min

SARMs Are A Bad Idea If You Have Low Natural Testosterone Levels

SARMs Are A Bad Idea If You Have Low Natural Testosterone Levels

The Reasons Why SARMs Are A Bad Idea If You Have Low Natural Testosterone Levels I'm going to briefly break down why I think SARMs are a bad idea if you have low natural testosterone levels. I often get asked by bodybuilders in their 40's to 50's who are looking into SARM experimentation what my recommendations are.… Learn more about your ad choices. Visit megaphone.fm/adchoices

23 Touko 20197min

Will Melanotan II Permanently Darken Your Skin? | How Long Do The Results Last?

Will Melanotan II Permanently Darken Your Skin? | How Long Do The Results Last?

Melanotan II Results Can Be Permanent Whether or not Melanotan II permanently tans your skin is something that isn't discussed often in relation to its use. I felt the need to address this because I'm a very experienced Melanotan II user and have researched it a lot over the years.… Learn more about your ad choices. Visit megaphone.fm/adchoices

22 Touko 20193min

Natural Bodybuilding Vs. Enhanced Bodybuilding While Cutting | TRT Is NOT The Equivalent Of A Natural

Natural Bodybuilding Vs. Enhanced Bodybuilding While Cutting | TRT Is NOT The Equivalent Of A Natural

Natural bodybuilding vs. enhanced bodybuilding while cutting yield significantly different outcomes. Even just TRT is not the equivalent of being a natural, even if your Testosterone levels are in the therapeutic “natural” range. I saw a bodybuilder who posted his bloodwork while he was preparing for a competition, and it was super insightful into the effects intense dieting has on the body because he's a natural athlete.… Learn more about your ad choices. Visit megaphone.fm/adchoices

22 Touko 20195min

How Long Do Kits Of GH And Peptides Last Before Degrading?

How Long Do Kits Of GH And Peptides Last Before Degrading?

Shelf Life Of GH And Peptides There are a lot of strong opinions about how long kits of GH and peptides last before degrading in room temperature, versus in a fridge, versus in the freezer. Most people are getting these products through black market means.… Learn more about your ad choices. Visit megaphone.fm/adchoices

21 Touko 20194min

The First Product You Should Use For Hair Loss Prevention

The First Product You Should Use For Hair Loss Prevention

What's the first product you should use for hair loss prevention? Obviously, there are a lot of drugs and chemicals on the market when it comes to hair loss prevention. There's a lot of junk, there's some stuff that works, but they vary greatly in side effect profiles, and some make much more logical sense to use as introductory methods of intervention.… Learn more about your ad choices. Visit megaphone.fm/adchoices

15 Touko 20195min

CB-03-01 (Breezula) Topical Anti-Androgen For Hair Loss Prevention – Initial Perceptions Of Its Efficacy

CB-03-01 (Breezula) Topical Anti-Androgen For Hair Loss Prevention – Initial Perceptions Of Its Efficacy

What Is CB-03-01? Clascoterone, also known more commonly as its developmental code name CB-03-01 is a synthetic steroidal antiandrogen. It acts as an androgen receptor antagonist and is being developed by Cassiopea as a potential treatment of androgen-dependent conditions including acne vulgaris and androgenic alopecia (male-pattern baldness).… Learn more about your ad choices. Visit megaphone.fm/adchoices

15 Touko 20198min

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