Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

At supraphysiological dosages, taking GH before going to sleep makes sense because there is a negative feedback loop on the growth hormone (GH)/insulin-like growth factor I (IGF-1) axis. In this study, IGF-1 was constantly infused, and the effect on endogenous GH secretion was assessed [R]. Overall, GH concentrations were suppressed during the rhIGF-I infusion by 85±3%, mainly by attenuating spontaneous GH pulse amplitude (77±4% suppression). The apparent GH pulse frequency was attenuated from 7.8±0.9 to 4.7±0.6 pulses/24h (P= 0.006). IGF-1 is the primary feedback, and the mechanism is similar to what you see with the HPTA axis. When there is enough Testosterone and Estrogen, your body has this mechanism in place to prevent you from making more. The same thing happens with exogenous GH use. When you administer exogenous GH, IGF-1 elevates. When your body recognizes that IGF-1 is elevated, it starts to suppress GH pulse amplitude in a dose dependent manner. If you are using supraphysiological amounts of GH for bodybuilding purposes, you can assume that your natural secretion is greatly inhibited during sleep as this negative feedback loop will prevent your body from secreting GH in your sleep like it normally would. When endogenous GH production is suppressed, administering exogenous GH at times that lipolysis or muscle growth can be optimized is the most logical approach to injection timing. https://youtu.be/8j9MGfQPeXg If fat loss is the goal, then taking GH in a fasted state prior to fasted cardio would be ideal. There is a ceiling on how much GH is needed to maximize lipolysis, so if your dosage exceeds 2 IU per day, then I would advise splitting up that dose into two (or more if needed) different periods of the day with as much time between them as possible. If muscle growth is the goal, GH should still be administered in a pulsatile fashion to mimic endogenous secretions. Topped out stimulation of autocrine IGF-1 in skeletal muscle can be achieved with fairly low dosages of exogenous GH, and administering a higher dose above and beyond that may just be a waste. This is why it would be wise to split up your daily GH dose into multiple administrations if you are using supraphysiological dosages. Learn more about your ad choices. Visit megaphone.fm/adchoices

Jaksot(1361)

I Thought Leo Died...

I Thought Leo Died...

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28 Tammi 202217min

Where I've Been...

Where I've Been...

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27 Tammi 202227min

Dan Bilzerian - PED's, Magic Juice, Biohacking, Dating, Wealth and Fame

Dan Bilzerian - PED's, Magic Juice, Biohacking, Dating, Wealth and Fame

📌 You can purchase Dan's new book "The Setup" here: https://dbthesetup.co/ ———————————— Dan's Social Media: Instagram: https://www.instagram.com/danbilzerian Facebook: https://www.facebook.com/danbilzerianofficial Twitter: https://twitter.com/DanBilzerian TikTok: https://www.tiktok.com/@danbilzerian YouTube: https://www.youtube.com/c/danbilzerian ———————————— 📍 Sponsors: 💊 Use code DEREK at checkout for 15% off your first month's supply of Seed's Daily Synbiotic: https://thld.co/seed_derek 🥄 Go to https://magicspoon.com/derek and use code DEREK to get your own variety pack of macro friendly/high protein cereal for $5 off ———————————— 🕑 Time Stamps: 00:00:00 – What Caused Dan's Heart Attack 00:04:20 – The Mind Warping Effect of Fame and Wealth at a Young Age 00:12:00 – Taxes on High Stakes Poker Earnings and Losses 00:15:06 – NFTs, CryptoPunks & If He Regrets Cashing Out of Bitcoin at $16,500 00:34:37 – Floyd Mayweather's Instagram Promo's, Steve Aoki & Social Media Strategy 00:41:32 – The Media's Portrayal of Dan's Downfall 00:48:43 – "Magic Juice", PED Use (Tren?) and Stem Cells 01:10:49 – The Natty Legend Mike O'Hearn 01:16:53 – Trans Athletes, Doping and The Capabilities of a Natty Physique 01:23:34 – How Dan Bilzerian Trained Himself to do Well with Women in College and Frat Life 01:37:18 – "The Game", Mystery Method and the OG Pick Up Artists 01:46:29 – Banging the Former CEO of Bodybuilding.com's 22 Year Old Girlfriend 01:55:02 – How Age Impacts Your Appeal to Women, Racial Disparity 02:10:32 – Tinder, Bumble and If Going to College is still Worth It 02:20:08 – Social Media and Smartphones are Modern Day Distractions 02:27:51 – NEW Perspective on Smoking and Dating Older Women 02:35:01 – Small Nuts And How My Deca Video Gave Him ED 02:40:50 – Melanotan II Transformations, Peptides, Ice Baths & His Current Diet 02:50:31 – Dan Bilzerian's Unfiltered Opinion on Dwayne 'The Rock' Johnson ———————————— 📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Gorilla Mind - My Pre-Workout, Nootropic, Performance & Health Focused Formulas) discount code "MPMD" for 10% off your entire order ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic infused energy drinks) 💡 https://intelligent.shop/derek (Intelligent Shop - Gorilla Mind's Sister Company For Niche Products) discount code "MPMD" for 10% off your entire order ⚕️ My Preventive Medicine & HRT Clinic: https://bit.ly/373k791 🧪 Blood Work: https://bit.ly/2wI3k9J 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | discount code "MPMD" for 10% off your entire order 🧴 Intelligent Minoxidil | The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | discount code "MPMD" for 10% off your entire order ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 🧴 The Skincare Products I Use: https://bit.ly/3pdS2DO - discount code "MPMD" for 10% off your entire order 🥩 The Best Newbie Friendly Diet For Muscle Growth (hits macros and micros): https://bit.ly/2JmpTGv 🧵 https://www.youngla.com/ (YoungLA Fitness & Lifestyle Clothing) discount code "MPMD" for 15% off your entire order ———————————— Follow Me On ———————————— INSTAGRAM: https://www.instagram.com/moreplatesmoredates/ THREADS: https://www.threads.net/@moreplatesmoredates FACEBOOK: https://www.facebook.com/moreplates/ SNAPCHAT: https://www.snapchat.com/add/derek-fit TWITTER: https://twitter.com/Derek_Fitness TIKTOK: https://www.tiktok.com/@moreplates ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR ———————————— #MorePlatesMoreDates #DanBilzerian #Podcast ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

21 Joulu 20213h 5min

Top Placing 2021 Mr. Olympia Bodybuilder's Cycle - Full Protocol Dissection

Top Placing 2021 Mr. Olympia Bodybuilder's Cycle - Full Protocol Dissection

Go to https://thld.co/seed_dereknov and get 15% off your first month’s supply of Seed’s Daily Synbiotic by using code DEREK at checkout. Thanks to Seed for sponsoring today’s video. ———————————— 🕑 Time Stamps:  00:00 - NAFLD 05:47 - Joesthetics & rippling muscles disease 12:58 - Trap Lore Ross YouTube channel 15:56 - Merchandise 18:45 - Top Mr. Olympia bodybuilder cycle review intro 21:45 - Bloodwork review 37:35 - Recommendations for next blood test part 1 41:06 - Wearable technology 45:03 - Recommendations for next blood test part 2/prostate 46:24 - Scanning/How to get it Thailand & Dubai 48:31 - Liver notes/health/protocol 49:36 - Udca/tudca + rest of liver protocol 57:18 - Sponsor 1:06:03 - Ancillary medications 1:06:47 - Post cycle therapy/fertility and bodybuilders coming FULLY off cycle 1:18:08 - Bloodwork findings/LDL 1:23:57 - ApoeB 1:27:57 - Bloodwork findings/blood pressure 1:28:56 - Bloodwork findings/cardiovascular health 1:31:33 - Bloodwork findings/liver 1:32:13 - Bloodwork findings/kidney/creatine/cyastatin C 1:34:52 - Bostin Loyd's health 1:36:47 - Creatine for bodybuilding 1:39:57 - Changes on bloodwork/internal bleeding 1:42:54 - Mr. Olympia contest prep cycle review 2:00:58 - Our opinion on the cycle/heart problem 2:10:08 - Leo’s story of the guy in Dubai with synthol + Wesley Vissers + round shoulders 2:15:06 - Tony Huge, Nick Trigili 2:17:55 - Weeks 10 to 6 2:23:26 - Protocol design 14 weeks in advance 2:27:57 - Weeks 6 to 4 2:31:21 - Injectable winstrol, leaving cosmetic compounds to the end 2:34:43 - SERMs + AIs, overlapping AIs 2:42:26 - Empiricism vs. theory in cycle design 2:45:20 - Confirmation bias/sampling 2:50:24 - Multiple DHT-based compounds? 2:53:26 - End of Olympia cycle review 2:54:34 - Why we presented this information to the audience 3:01:09 - Having a positive calcium score at 40/Guy Cisternino and Lee Priest CAC scores 3:02:31 - The need for prophylactic lipid management for bodybuilders: ezetimibe, statins, PCSK9i 3:04:02 - Is Steve going bald? ———————————— 📩 My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW ———————————— 🦍 https://gorillamind.com/derek (Gorilla Mind - My Pre-Workout, Nootropic, Performance & Health Focused Formulas) discount code "MPMD" for 10% off your entire order ⚡ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic infused energy drinks) 💡 https://intelligent.shop/derek (Intelligent Shop - Gorilla Mind's Sister Company For Niche Products) discount code "MPMD" for 10% off your entire order ⚕️ My Preventive Medicine & HRT Clinic: https://bit.ly/373k791 🧪 Blood Work: https://bit.ly/2wI3k9J 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | discount code "MPMD" for 10% off your entire order 🧴 Intelligent Minoxidil | The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | discount code "MPMD" for 10% off your entire order ⚕️ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 🧴 The Skincare Products I Use: https://bit.ly/3pdS2DO - discount code "MPMD" for 10% off your entire order 🥩 The Best Newbie Friendly Diet For Muscle Growth (hits macros and micros): https://bit.ly/2JmpTGv 🧵 https://www.youngla.com/ (YoungLA Fitness & Lifestyle Clothing) discount code "MPMD" for 15% off your entire order ———————————— Follow Me On ———————————— INSTAGRAM: https://www.instagram.com/moreplatesmoredates/ THREADS: https://www.threads.net/@moreplatesmoredates FACEBOOK: https://www.facebook.com/moreplates/ SNAPCHAT: https://www.snapchat.com/add/derek-fit TWITTER: https://twitter.com/Derek_Fitness TIKTOK: https://www.tiktok.com/@moreplates ———————————— Subscribe To The More Plates More Dates Podcast ———————————— Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR ———————————— #MorePlatesMoreDates #MrOlympia #Bodybuilding ———————————— Learn more about your ad choices. Visit megaphone.fm/adchoices

30 Marras 20213h 11min

Watching Porn Between Sets To Improve Performance

Watching Porn Between Sets To Improve Performance

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25 Marras 202114min

The ONE THING Jacked Guys Over 50 Do (lol)

The ONE THING Jacked Guys Over 50 Do (lol)

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25 Marras 202125min

Women's Sports Were Just Killed

Women's Sports Were Just Killed

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25 Marras 202114min

Henry Cavill’s Stack Revealed - My Analysis

Henry Cavill’s Stack Revealed - My Analysis

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24 Marras 202135min

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