#164 – Kevin Esvelt on cults that want to kill everyone, stealth vs wildfire pandemics, and how he felt inventing gene drives

#164 – Kevin Esvelt on cults that want to kill everyone, stealth vs wildfire pandemics, and how he felt inventing gene drives

"Imagine a fast-spreading respiratory HIV. It sweeps around the world. Almost nobody has symptoms. Nobody notices until years later, when the first people who are infected begin to succumb. They might die, something else debilitating might happen to them, but by that point, just about everyone on the planet would have been infected already.

And then it would be a race. Can we come up with some way of defusing the thing? Can we come up with the equivalent of HIV antiretrovirals before it's too late?" — Kevin Esvelt

In today’s episode, host Luisa Rodriguez interviews Kevin Esvelt — a biologist at the MIT Media Lab and the inventor of CRISPR-based gene drive — about the threat posed by engineered bioweapons.

Links to learn more, summary and full transcript.

They cover:

  • Why it makes sense to focus on deliberately released pandemics
  • Case studies of people who actually wanted to kill billions of humans
  • How many people have the technical ability to produce dangerous viruses
  • The different threats of stealth and wildfire pandemics that could crash civilisation
  • The potential for AI models to increase access to dangerous pathogens
  • Why scientists try to identify new pandemic-capable pathogens, and the case against that research
  • Technological solutions, including UV lights and advanced PPE
  • Using CRISPR-based gene drive to fight diseases and reduce animal suffering
  • And plenty more.

Producer and editor: Keiran Harris
Audio Engineering Lead: Ben Cordell
Technical editing: Simon Monsour
Additional content editing: Katy Moore and Luisa Rodriguez
Transcriptions: Katy Moore

Jaksot(320)

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If digital minds could suffer, how would we ever know? (Article)

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“I want everyone to understand that I am, in fact, a person.” Those words were produced by the AI model LaMDA as a reply to Blake Lemoine in 2022. Based on the Google engineer’s interactions with the ...

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#132 Classic episode – Nova DasSarma on why information security may be critical to the safe development of AI systems

#132 Classic episode – Nova DasSarma on why information security may be critical to the safe development of AI systems

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#138 Classic episode – Sharon Hewitt Rawlette on why pleasure and pain are the only things that intrinsically matter

What in the world is intrinsically good — good in itself even if it has no other effects? Over the millennia, people have offered many answers: joy, justice, equality, accomplishment, loving god, wisd...

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#134 Classic episode – Ian Morris on what big-picture history teaches us

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#140 Classic episode – Bear Braumoeller on the case that war isn’t in decline

#140 Classic episode – Bear Braumoeller on the case that war isn’t in decline

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2024 Highlightapalooza! (The best of The 80,000 Hours Podcast this year)

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#211 – Sam Bowman on why housing still isn't fixed and what would actually work

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