The Interchromatin Network Model (Ana Pombo)

The Interchromatin Network Model (Ana Pombo)

In this Episode of the Epigenetics Podcast our guest Ana Pombo from the Max-Delbrück-Center in Berlin provides insight in her work on the interplay between gene regulation and genome architecture. To do so she and her team use different state of the art methods, including cryo-sectioning to unravel this regulatory network. In 2006, they proposed the Interchromatin Network Model of chromosome organization which postulates that chromosome folding is driven by contacts between different genomic regions and between chromatin and nuclear landmarks, such as the nuclear lamina. And later on they used polymer physics modeling to study those mechanisms, which lead to the development of the Strings & Binders Switch (SBS) model. And this is just a glimpse of the topics that are discussed in this Episode.

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Epigenetic Consequences of DNA Methylation in Development (Maxim Greenberg)

Epigenetic Consequences of DNA Methylation in Development (Maxim Greenberg)

In this episode of the Epigenetics Podcast, we talked with Maxim Greenberg from the Institute Jacob Monot about his work on epigenetic consequences of DNA methylation in development. In this interview...

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R-Loop Biology in Health and Disease (Natalia Gromak)

R-Loop Biology in Health and Disease (Natalia Gromak)

In this episode of the Epigenetics Podcast, we talked with Natalia Gromak from the University of Oxford about her work on R-Loop biology in health and disease. In this interview Dr. Gromak delves into...

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The Menin-MLL Complex and Small Molecule Inhibitors (Yadira Soto-Feliciano)

The Menin-MLL Complex and Small Molecule Inhibitors (Yadira Soto-Feliciano)

In this episode of the Epigenetics Podcast, we talked with Yadira Soto-Feliciano from MIT about her work on the Menin-MLL complex and the effect of small molecules on its stability in leukemia. We exp...

21 Marras 202440min

Grant Writing in Academia and Industry – Tips for Success (Mary Anne Jelinek)

Grant Writing in Academia and Industry – Tips for Success (Mary Anne Jelinek)

In this episode of the Epigenetics Podcast, we talked with Mary Anne Jelinek Associate Director of R&D at Active Motif about writing and reviewing grants in academia and industry. Learn from Dr. Jelin...

14 Marras 202439min

DNase Hypersensitive Sites and Chromatin Remodeling Enzymes (Carl Wu)

DNase Hypersensitive Sites and Chromatin Remodeling Enzymes (Carl Wu)

In this episode of the Epigenetics Podcast, we talked with Carl Wu from John's Hopkins University about his work on nucleosome remodeling, histone variants, and the role of single-molecule imaging in ...

31 Loka 202455min

Epigenetic Mechanisms of Mammalian Germ Cell Development (Mitinori Saitou)

Epigenetic Mechanisms of Mammalian Germ Cell Development (Mitinori Saitou)

In this episode of the Epigenetics Podcast, we talked with Mitinori Saitou from Kyoto University about his work on germ cell development, focusing on proteins like BLIMP1 and PRDM14, reprogramming iPS...

17 Loka 202439min

Malaria Chromatin Structure and its Transcriptional Regulation (Karine Le Roch)

Malaria Chromatin Structure and its Transcriptional Regulation (Karine Le Roch)

In this episode of the Epigenetics Podcast, we talked with Karine Le Roch from the University of California at Riverside about her work on malaria chromatin structure and its transcriptional regulatio...

3 Loka 202441min

Characterizing Chromatin at the Nuclear Lamina (Bas van Steensel)

Characterizing Chromatin at the Nuclear Lamina (Bas van Steensel)

In this episode of the Epigenetics Podcast, we talked with Bas van Steensel from the Netherlands Cancer Institute about his work on characterizing chromatin at the Nuclear Lamina. The Interview starts...

19 Syys 202440min

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