Influence of Histone Variants on Chromatin Structure and Metabolism (Markus Buschbeck)
Epigenetics Podcast16 Joulu 2019

Influence of Histone Variants on Chromatin Structure and Metabolism (Markus Buschbeck)

In this episode of the Epigenetics Podcast, we sat down with Marcus Buschbeck, Group Leader at the Josep Carreras Leukaemia Research Institute in Barcelona, to talk about his work on the histone variant macroH2A, its role in metabolism and how it contributes to the regulation of chromatin structure.

Histone variants equip chromatin with unique properties and show a specific genomic distribution. The histone variant macroH2A is unique in having a tripartite structure consisting of a N-terminal histone-fold, an intrinsically unstructured linker domain and a C-terminal macro domain. Recent discoveries show that macroH2A proteins have a major role in the nuclear organization which has the potential to explain how these proteins can act as tumor suppressors, promoters of differentiation and barriers to somatic cell reprogramming.

We discuss these topics, the mission of the Josep Carreras Leukaemia Research Institute, and much more in this episode.

References

Contact

Jaksot(168)

Advanced Optical Imaging in 3D Nuclear Organisation (Lothar Schermelleh)

Advanced Optical Imaging in 3D Nuclear Organisation (Lothar Schermelleh)

In this episode of the Epigenetics Podcast, we talked with Lothar Schermelleh from the University of Oxford about his work on advanced optical imaging in 3D nuclear organisation.  The interview start...

27 Kesä 202446min

DNA Replication, Transcription and R-loops (Stephan Hamperl)

DNA Replication, Transcription and R-loops (Stephan Hamperl)

In this episode of the Epigenetics Podcast, we talked with Dr. Stephan Hamperl from the Helmholtz Zentrum Munich about his work on how conflicts between transcription, replication, and R-loop formatio...

13 Kesä 202434min

Mutations of Gene Regulatory Elements in Human Disease (Nadav Ahituv)

Mutations of Gene Regulatory Elements in Human Disease (Nadav Ahituv)

In this episode of the Epigenetics Podcast, we talked with Nadav Ahituv from University of California, San Francisco about his work on mutations of gene regulatory elements in human disease. Using mas...

30 Touko 202449min

Using Single-Cell Multiomics to Characterize Human Developmental Hematopoiesis (Ana Cvejic)

Using Single-Cell Multiomics to Characterize Human Developmental Hematopoiesis (Ana Cvejic)

In this episode of the Epigenetics Podcast, we talked with Ana Cvejic from the Biotech Research & Innovation Centre at the University of Copenhagen about her work on using sc-multiomics to characteris...

16 Touko 202437min

The Impact of Sequence Variation on Transcription Factor Binding (Sven Heinz)

The Impact of Sequence Variation on Transcription Factor Binding (Sven Heinz)

In this episode of the Epigenetics Podcast, we talked with Sven Heinz from the University of California in San Diego about his work on the impact of sequence variation on transcription factor binding ...

2 Touko 202440min

Comparing CUT&Tag to ENCODE ChIP-Seq in Alzheimer's Disease Samples (Sarah Marzi)

Comparing CUT&Tag to ENCODE ChIP-Seq in Alzheimer's Disease Samples (Sarah Marzi)

In this episode of the Epigenetics Podcast, we talked with Sarah Marzi from the UK Dementia Research Institute at Imperial College London about her work on epigenetic changes in Alzheimer's Disease, a...

18 Huhti 202446min

The Role of Hat1p in Chromatin Assembly (Mark Parthun)

The Role of Hat1p in Chromatin Assembly (Mark Parthun)

In this episode of the Epigenetics Podcast, we talked with Mark Parthun from Ohio State University about his work on the role of Hat1p in chromatin assembly. Mark Parthun shares insights into his pivo...

4 Huhti 202447min

The Impact of Paternal Diet on Offspring Metabolism (Upasna Sharma)

The Impact of Paternal Diet on Offspring Metabolism (Upasna Sharma)

In this episode of the Epigenetics Podcast, we talked with Upasna Sharma from UC Santa Cruz about her work on a number of interesting projects on H2A.Z and telomeres, the impact of paternal diet on of...

21 Maalis 202436min

Suosittua kategoriassa Tiede

tiedekulma-podcast
rss-mita-tulisi-tietaa
rss-poliisin-mieli
docemilia
radio-antro
utelias-mieli
rss-sosiopodi
ihanat-ipanat
mielipaivakirja
filocast-filosofian-perusteet
rss-bios-podcast
rss-laakaripodi
rss-radplus
rss-opeklubi