Structural Analysis of Nucleosomes During Transcription (Lucas Farnung)
Epigenetics Podcast15 Kesä 2023

Structural Analysis of Nucleosomes During Transcription (Lucas Farnung)

In this episode of the Epigenetics Podcast, we caught up with Lucas Farnung from Harvard Medical School to talk about his work on the structural analysis of nucleosomes during transcription.

Lucas Farnung started his scientific career in Patrick Cramer's lab, trying to solve the cryo-EM structure of RNA polymerase II transcribing through a nucleosome. This project spanned some time before being published in 2018, during which time Dr. Farnung accomplished several other goals. The team solved the cryo-electron microscopy structure of Chd1 from the yeast Saccharomyces cerevisiae bound to a nucleosome at a resolution of 4.8 Å, solved the structure of the nucleosome-CHD4 chromatin remodeler, and investigated the structural basis of nucleosome transcription mediated by Chd1 and FACT. In 2021, he started his own lab and is now working on structural analysis of nucleosomes during transcription and how chromatin remodelers work on the chromatin template.

References

  • Farnung, L., Vos, S. M., Wigge, C., & Cramer, P. (2017). Nucleosome-Chd1 structure and implications for chromatin remodelling. Nature, 550(7677), 539–542. https://doi.org/10.1038/nature24046

  • Farnung, L., Vos, S. M., & Cramer, P. (2018). Structure of transcribing RNA polymerase II-nucleosome complex. Nature communications, 9(1), 5432. https://doi.org/10.1038/s41467-018-07870-y

  • Filipovski, M., Soffers, J. H. M., Vos, S. M., & Farnung, L. (2022). Structural basis of nucleosome retention during transcription elongation. Science (New York, N.Y.), 376(6599), 1313–1316. https://doi.org/10.1126/science.abo3851

Related Episodes

Jaksot(168)

Influence of Histone Variants on Chromatin Structure and Metabolism (Markus Buschbeck)

Influence of Histone Variants on Chromatin Structure and Metabolism (Markus Buschbeck)

In this episode of the Epigenetics Podcast, we sat down with Marcus Buschbeck, Group Leader at the Josep Carreras Leukaemia Research Institute in Barcelona, to talk about his work on the histone varia...

16 Joulu 201931min

Epigenetic Mechanisms of Aging and Longevity (Shelley Berger)

Epigenetic Mechanisms of Aging and Longevity (Shelley Berger)

In this Episode we sat down with Shelley Berger, Keynote Speaker at the "EMBO | EMBL Symposium: Metabolism Meets Epigenetics" to talk about her work on Epigenetic Mechanisms of Aging and Longevity. On...

21 Marras 201938min

Epigenetics & Glioblastoma: New Approaches to Treat Brain Cancer (Lucy Stead)

Epigenetics & Glioblastoma: New Approaches to Treat Brain Cancer (Lucy Stead)

In this Episode of the Epigenetics Podcast our guest Lucy Stead from the University of Leeds provides insight into her work on intratumor heterogeneity in Glioblastoma. In order to tackle this area sh...

15 Loka 201943min

The Past, Present, and Future of Epigenetics (Joe Fernandez, founder of Active Motif)

The Past, Present, and Future of Epigenetics (Joe Fernandez, founder of Active Motif)

Joe Fernandez, the founder of Active Motif, has played a significant role in the evolution of the biotechnology industry. He’s seen where the industry has been, and he has a good idea where it’s going...

5 Syys 201923min

The Interchromatin Network Model (Ana Pombo)

The Interchromatin Network Model (Ana Pombo)

In this Episode of the Epigenetics Podcast our guest Ana Pombo from the Max-Delbrück-Center in Berlin provides insight in her work on the interplay between gene regulation and genome architecture. To ...

12 Elo 201929min

Dosage Compensation in Drosophila (Asifa Akhtar)

Dosage Compensation in Drosophila (Asifa Akhtar)

Dosage compensation is an essential process to regulate the gene expression of the X-chromosome in female and male flies. Thereby the mechanism of regulation in humans and in drosophila is different. ...

16 Heinä 201936min

Spatial Organization of the Human Genome (Wendy Bickmore)

Spatial Organization of the Human Genome (Wendy Bickmore)

In recent years it has become more and more evident, that genome folding and chromatin packaging into the nucleus plays a pivotal role in the regulation of gene expression. In this Episode of our Podc...

11 Kesä 201931min

Heterochromatin and Phase Separation (Gary Karpen)

Heterochromatin and Phase Separation (Gary Karpen)

Heterochromatin plays a pivotal role in organizing our genome in the nucleus and separating active from inactive genomic regions. In this Podcast Episode our Guest Gary Karpen from UC Berkeley sits do...

9 Touko 201934min

Suosittua kategoriassa Tiede

tiedekulma-podcast
rss-mita-tulisi-tietaa
rss-poliisin-mieli
docemilia
rss-duodecim-lehti
rss-sosiopodi
radio-antro
filocast-filosofian-perusteet
rss-ammamafia
utelias-mieli
mielipaivakirja
rss-bios-podcast
rss-astetta-parempi-elama-podcast
rss-tiedetta-vai-tarinaa
rss-luontopodi-samuel-glassar-tutkii-luonnon-ihmeita