Structural Analysis of Nucleosomes During Transcription (Lucas Farnung)
Epigenetics Podcast15 Kesä 2023

Structural Analysis of Nucleosomes During Transcription (Lucas Farnung)

In this episode of the Epigenetics Podcast, we caught up with Lucas Farnung from Harvard Medical School to talk about his work on the structural analysis of nucleosomes during transcription.

Lucas Farnung started his scientific career in Patrick Cramer's lab, trying to solve the cryo-EM structure of RNA polymerase II transcribing through a nucleosome. This project spanned some time before being published in 2018, during which time Dr. Farnung accomplished several other goals. The team solved the cryo-electron microscopy structure of Chd1 from the yeast Saccharomyces cerevisiae bound to a nucleosome at a resolution of 4.8 Å, solved the structure of the nucleosome-CHD4 chromatin remodeler, and investigated the structural basis of nucleosome transcription mediated by Chd1 and FACT. In 2021, he started his own lab and is now working on structural analysis of nucleosomes during transcription and how chromatin remodelers work on the chromatin template.

References

  • Farnung, L., Vos, S. M., Wigge, C., & Cramer, P. (2017). Nucleosome-Chd1 structure and implications for chromatin remodelling. Nature, 550(7677), 539–542. https://doi.org/10.1038/nature24046

  • Farnung, L., Vos, S. M., & Cramer, P. (2018). Structure of transcribing RNA polymerase II-nucleosome complex. Nature communications, 9(1), 5432. https://doi.org/10.1038/s41467-018-07870-y

  • Filipovski, M., Soffers, J. H. M., Vos, S. M., & Farnung, L. (2022). Structural basis of nucleosome retention during transcription elongation. Science (New York, N.Y.), 376(6599), 1313–1316. https://doi.org/10.1126/science.abo3851

Related Episodes

Jaksot(167)

Malaria Chromatin Structure and its Transcriptional Regulation (Karine Le Roch)

Malaria Chromatin Structure and its Transcriptional Regulation (Karine Le Roch)

In this episode of the Epigenetics Podcast, we talked with Karine Le Roch from the University of California at Riverside about her work on malaria chromatin structure and its transcriptional regulatio...

3 Loka 202441min

Characterizing Chromatin at the Nuclear Lamina (Bas van Steensel)

Characterizing Chromatin at the Nuclear Lamina (Bas van Steensel)

In this episode of the Epigenetics Podcast, we talked with Bas van Steensel from the Netherlands Cancer Institute about his work on characterizing chromatin at the Nuclear Lamina. The Interview starts...

19 Syys 202440min

Nucleosome Positioning in Cancer Diagnostics (Vladimir Teif)

Nucleosome Positioning in Cancer Diagnostics (Vladimir Teif)

In this episode of the Epigenetics Podcast, we caught up with Vladimir Teif from the University of Essex to talk about his work on nucleosome positioning in development and disease. Vladimir's researc...

5 Syys 202440min

The Effect of Histone Demethylases on Gene Expression and Cancer Cell Stability (Johnathan Whetstine)

The Effect of Histone Demethylases on Gene Expression and Cancer Cell Stability (Johnathan Whetstine)

In this episode of the Epigenetics Podcast, we talked with Johnathan Whetstine from Fox Chase Cancer Center about his work on how histone demethylases affect gene expression and cancer cell stability....

29 Elo 202439min

Stem Cell Transcriptional Regulation in Naive vs. Primed Pluripotency (Christa Buecker)

Stem Cell Transcriptional Regulation in Naive vs. Primed Pluripotency (Christa Buecker)

In this episode of the Epigenetics Podcast, we talked with Christa Buecker from the Max Perutz Laboratories in Vienna about her work on transcriptional regulation during early embryonic development. D...

8 Elo 202436min

Gene Expression Control and Intricacies of X-chromosome Inactivation (Claire Rougeulle)

Gene Expression Control and Intricacies of X-chromosome Inactivation (Claire Rougeulle)

In this episode of the Epigenetics Podcast, we talked with Claire Rougeulle from the Epigenetics and Cell Fate Center at Université Paris City about her work on gene expression control, the intricacie...

25 Heinä 202438min

Epigenetic Mechanisms in Genome Regulation and Developmental Programming (James Hackett)

Epigenetic Mechanisms in Genome Regulation and Developmental Programming (James Hackett)

In this episode of the Epigenetics Podcast, we talked with James Hackett from the EMBL in Rome about his work on epigenetic mechanisms in genome regulation and developmental programming. One of James ...

11 Heinä 202437min

Advanced Optical Imaging in 3D Nuclear Organisation (Lothar Schermelleh)

Advanced Optical Imaging in 3D Nuclear Organisation (Lothar Schermelleh)

In this episode of the Epigenetics Podcast, we talked with Lothar Schermelleh from the University of Oxford about his work on advanced optical imaging in 3D nuclear organisation.  The interview start...

27 Kesä 202446min

Suosittua kategoriassa Tiede

rss-mita-tulisi-tietaa
rss-poliisin-mieli
rss-lihavuudesta-podcast
utelias-mieli
tiedekulma-podcast
rss-duodecim-lehti
rss-opeklubi
docemilia
hippokrateen-vastaanotolla
mielipaivakirja
radio-antro
rss-laakaripodi
rss-mental-race
rss-luontopodi-samuel-glassar-tutkii-luonnon-ihmeita