Gene Dosage Alterations in Evolution and Ageing (Claudia Keller Valsecchi)
Epigenetics Podcast29 Kesä 2023

Gene Dosage Alterations in Evolution and Ageing (Claudia Keller Valsecchi)

In this episode of the Epigenetics Podcast, we caught up with Claudia Keller Valsecchi from the Institute for Molecular Biology in Mainz to talk about her work on gene dosage alterations in evolution and ageing.

Claudia Keller-Valsecchi's team focuses on understanding the fundamental mechanisms of how cellular function in eukaryotes is influenced by gene copy number variation. Recent findings indicate that precise MSL2-mediated gene dosage is highly relevant for organismal development. Since 2020 Claudia Keller-Valsecchi runs her own lab at the IMB in Mainz, Germany, where she tries to understand from a molecular mechanistic point of view how gene dosage compensation works, with projects in mosquitoes and in Artemia franciscanagene, as well as dosage regulation in the mammalian system regarding development and disease.

References

  • Keller, C., Adaixo, R., Stunnenberg, R., Woolcock, K. J., Hiller, S., & Bühler, M. (2012). HP1Swi6 Mediates the Recognition and Destruction of Heterochromatic RNA Transcripts. Molecular Cell, 47(2), 215–227. https://doi.org/10.1016/j.molcel.2012.05.009

  • Valsecchi, C.I.K., Basilicata, M.F., Georgiev, P. et al. RNA nucleation by MSL2 induces selective X chromosome compartmentalization. Nature 589, 137–142 (2021). https://doi.org/10.1038/s41586-020-2935-z

  • Keller Valsecchi, C. I., Marois, E., Basilicata, M. F., Georgiev, P., & Akhtar, A. (2021). Distinct mechanisms mediate X chromosome dosage compensation in Anopheles and Drosophila. Life Science Alliance, 4(9), e202000996. https://doi.org/10.26508/lsa.202000996

Related Episodes

Jaksot(169)

H3K4me3, Set-Proteins, Isw1 and their Role in Transcription (Jane Mellor)

H3K4me3, Set-Proteins, Isw1 and their Role in Transcription (Jane Mellor)

In this episode of the Epigenetics Podcast, we caught up with Jane Mellor from the University of Oxford to talk about her work on H3K4me3, SET proteins, Isw1 and their role in transcription. Since the...

13 Tammi 202242min

The role of DNA Methylation in Epilepsy (Katja Kobow)

The role of DNA Methylation in Epilepsy (Katja Kobow)

In this episode of the Epigenetics Podcast, we caught up with Katja Kobow from the Universitätsklinikum Erlangen to talk about her work on the role of DNA methylation in Epilepsy. Katja Kobow started ...

16 Joulu 202135min

MacroH2A Function in Development and Disease (Emily Bernstein)

MacroH2A Function in Development and Disease (Emily Bernstein)

In this episode of the Epigenetics Podcast, we caught up with Emily Bernstein from Icahn Schoon of Medicine at Mount Sinai to talk about her work on MacroH2A function and the role of Polycomb proteins...

2 Joulu 202132min

Spatio-Temporal Alterations in Chromosome Dynamics (Jane Skok)

Spatio-Temporal Alterations in Chromosome Dynamics (Jane Skok)

In this episode of the Epigenetics Podcast, we caught up with Jane Skok from New York University School of Medicine to talk about her work on spatio-temporal alterations in chromosome dynamics. Studie...

18 Marras 202142min

Chromatin Organization During Development and Disease (Marieke Oudelaar)

Chromatin Organization During Development and Disease (Marieke Oudelaar)

In this episode of the Epigenetics Podcast, we caught up with Marieke Oudelaar from the Max Planck Institute for Biophysical Chemistry to talk about her work on chromatin organization during developme...

11 Marras 202138min

Enhancers and Chromatin Remodeling in Mammary Gland Development (Camila dos Santos)

Enhancers and Chromatin Remodeling in Mammary Gland Development (Camila dos Santos)

In this episode of the Epigenetics Podcast, we caught up with Camila dos Santos from Cold Spring Harbor Laboratories to talk about her work on enhancers and chromatin remodeling in mammary gland devel...

28 Loka 202137min

The Role of SMCHD1 in Development and Disease (Marnie Blewitt)

The Role of SMCHD1 in Development and Disease (Marnie Blewitt)

In this episode of the Epigenetics Podcast, we caught up with Marnie Blewitt from the Walter and Eliza Hall Institute of Medical Research to talk about her work on the role of SMCHD1 in Development an...

14 Loka 202130min

Single-Molecule Imaging of the Epigenome (Efrat Shema)

Single-Molecule Imaging of the Epigenome (Efrat Shema)

In this episode of the Epigenetics Podcast, we caught up with Efrat Shema from the Weizmann Institute of Science to talk about her work on Single Molecule Imaging of chromatin, and the analysis of nuc...

30 Syys 202139min

Suosittua kategoriassa Tiede

rss-poliisin-mieli
tiedekulma-podcast
rss-mita-tulisi-tietaa
docemilia
rss-luontopodi-samuel-glassar-tutkii-luonnon-ihmeita
rss-duodecim-lehti
utelias-mieli
radio-antro
filocast-filosofian-perusteet
rss-astetta-parempi-elama-podcast
rss-lapsuuden-rakentajat-podcast
rss-lihavuudesta-podcast
rss-sosiopodi