Biohacking Alzheimers, Age Reversal, Young Blood, Stem Cells, Exosomes & More!
Boundless Life20 Syys 2018

Biohacking Alzheimers, Age Reversal, Young Blood, Stem Cells, Exosomes & More!

You've no doubt heard of it by now...

In an attempt to live longer, some anti-aging enthusiasts are getting themselves injected with the blood of young humans, via a process deemed: plasmaphoresis.

This podcast is about several age reversal therapies. It's also about biohacking Alzheimers. It's about all these therapies (senolytics, exosomes, gdf-11, etc) that scientists have been talking about for age reversal. The podcast is about biological aging clocks and biomarkers to measure them. You'll learn about ways that you can biohack Alzheimer's disease, how to measure your biological age, how to reverse aging, what the biggest obstacle to age reversal is, how to get more involved in the anti-aging community and more.

About the Guests

Mark Urdahl, is a technology entrepreneur from the Silicon Valley. He has numerous patents and has worked in big data. He began his career at IBM's medical instruments subsidiary that pioneered plasmaphoresis. Mark founded the Youngblood Institute to advance new uses for well established therapeutic plasma exchange therapies which have recently evidenced a previously undocumented potential to rejuvenate the body's own stem cells, restore aging immune systems, and prevent the onset of many age-related disease condition, so that we might live healthy as we age and ultimately live longer lives.

Tom Ingloglia first appeared on this podcast in the episode "The Next Big Anti-Aging Drug: Everything You Need To Know About “NAD”." As you learn in that episode, Tom is a private investor with a master’s degree in finance. In the midst of trading, investing in technology and developing real estate in Costa Rica, Tom became very sick. He was initially prescribed antibiotics, suffered from an adverse reaction and was told that he’d have stomach problems for the rest of his life. In the years that followed, Tom also developed severe food allergies. His symptoms worsened, and he next began dealing with insomnia, anxiety, muscle pain, tendinopathies, joint pain, chronic fatigue syndrome, altered and clouded cognition and headaches. He finally had a mental breakdown in 2008.

After a prolonged period of taking antibiotics, Tom began experiencing tendonitis throughout his fingers, hands, wrists and ankles and feet, so he started taking pain medications to relieve this pain. He had to give up his career in trading because his sole focus for the next eight years would be on finding a cure to his growing symptoms. His life consisted of working with physical therapists, going to the gym, going to new doctors, and trying new foods to see if it would help. Throughout Tom’s eight-year battle, he was prescribed consistently and persistently more medication.

For six years, he was taking excessive amounts of Hydrocodone and Tramadol every day. Tom became obsessed with researching symptoms and treatments, and learned about the NAD+ treatment. He visited a clinic, and on Day 7 of his treatment, “It hit me. I started feeling better. I felt amazing. There was a calm that came over me. I felt safe. I just had no cravings for drugs or pain meds. There was no need for them. I just didn’t have the excruciating pain that I had before. I felt eight years of pain melting away.” Tom has nearly fully recovered, using related treatments to NAD+, and has engaged two cofounders to assist him in building out a facility to help bring this treatment to others in similar situations.

In my conversation with Mark and Tom, you'll discover:

-The history of The Young Blood Institute and how "heterochronic plasma exchange" works...16:00

  • Heterochronic plasma means simply removing old plasma and replacing it with "young" plasma.
  • Others are experimenting with this concept.
  • What Mark does is different from a plasma "infusion."
  • Plasma is approximately half of our blood volume.
  • Mark began with IBM Biomedical Systems, who had invented what we now call the "blood cell processor."

-The intricate means of testing used on mice...22:15

  • Basically creating "siamese twins" with mice by stitching them together.
  • Similar procedures have been conducted on humans for over 50 years.
  • Mark wanted to recruit the best medical professionals to the Young Blood Institute. Many of them have been doing it for 30-40 years.

-What, if any, are the risks of these plasma exchanges...29:10

  • Roughly a 4% risk of a transfusion reaction, which is akin to what you might experience donating blood.
  • One of the safer procedures in the medical field today.
  • You go through 6 exchanges as part of a protocol.

-The network of doctors that Mark and Tom have built to do a plasma exchange...32:42

  • There are medical professionals all over the U.S. that can do the procedure.
  • Submit an inquiry on the Young Blood Institute website to find a doctor that is near you.

-What anti-aging biomarkers Mark is tracking at the Young Blood Institute...34:51

  • They have more technology testing capability than Stanford, Johns Hopkins and Harvard combined.
  • Key technology: time of flight mass cytometry. Single cell proteionomics.
  • They are trying to develop early detection biomarkers that enables them to prevent the onset of diseases before they become significant.

-The lowest hanging fruit for people to track...46:15

  • The YBI's concern is the function of the body, rather than the age.
  • Your cells are not aware of your "age".

-What a biological aging clock is...50:20

  • Zymo is a lab that has worked with Steven Horvath. Zymo DNA Methylation Aging Clock
  • Looked at DNA, and seen a pattern from methyl groups attached to certain parts of the genome.

-How can we track biological aging, or slow down our biological aging clock?...52:30

  • Inflammatory markers, heart age, brain age, lung age, skin elasticity.

-The anti-aging booth that Mark and Tom will be operating at a conference called RAAD Fest...54:45

  • Revolution Against Aging and Death
  • Want to have a contest where people calculate their age, and track their progress.
  • Mark and Tom have one of the largest booths at the conference.

-Whether NAD actually gets absorbed into a cell via injections or IV...1:00:30

  • How does Ben feel with an injection? Answer: Incredible.
  • Tom doesn't recommend the injection due to the level of discomfort.

-Why compounded formulas such as glutathione and Vitamin B could be taken off the market soon...1:07:30

  • There's a review similar to a court hearing, where people argue for and against glutathione.
  • Taken off the market for compounding pharmacies.
  • Tom "has his own reasons" for why this could be deemed unsafe.
  • Core problem: the vitamins don't have any intellectual property. Could affect the costs of healthcare.

-How to use technologies such as Vielight and exosomes to address Alzheimer's...1:14:30

  • Alzheimers is a $500 billion industry; the 6th leading cause of death.
  • A Vielight is basically a laser light for your nose and head; photobiomodulation on your skull.

-What GDF11 mRNA is and how it works to improve hearing, smell and sight...1:25:30

  • GDF11 is a DNA repair molecule; makes stem cells active again.
  • Patients see improvements in sex drive, vision, smell, hearing, etc.
  • Legal hurdles to being able to administer it.
  • "Unofficial" results are very positive.

-How senolytics works as a therapy for aging and Alzheimer's, and the importance of quercetin and tocotrienols...1:33:45

  • Describes small molecules that lead to the death of "zombie" cells that don't help the rest of your body.
  • Life Extension article "Natural Compounds that Remove Aging Cells"

-And much more...

Resources from this episode:

-The NAD Treatment Center -NAD conference -Brain Research Center -The Revolutionary RX Podcast -Beyond NAD Conference - Use discount code "BenlovesNAD" at check out

-Connexin 43 hemi channels mediate Ca2+-regulated transmembrane NAD+ fluxes in intact cells

-3T3 L1 Cell Line from mouse

-PRESERVING PATIENT ACCESS TO COMPOUNDED MEDICATIONS H.R. 2871 -Bulk Drug Substances Nominated for Use in Compounding Under Section 503B of the Federal Food, Drug, and Cosmetic Act

-Forecasting the global burden of Alzheimer’s disease

-Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer’s mouse models

-Activation of SIRT3 by the NAD⁺ precursor nicotinamide riboside protects from noise-induced hearing loss.

-Nicotinamide restores cognition in AD transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau

-Dr Nady Braidy

-Alzheimer’s Disease Statistics

-The Bredesen Protocol

-Book: The End of Alzheimer’s: The First Program to Prevent and Reverse Cognitive Decline by Dr. Dale Bredesen -The Vielight -Exosomes Podcast: The Single, Most Comprehensive Stem Cell Procedure Known To Humankind: How A "Full Body Stem Cell & Exosome Makeover" Works.

-Umbilical cord mesenchymal stem cells derived extracellular vesicles can safely ameliorate the progression of chronic kidney diseases

-Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. -Steve Perry's GDF11 Presentation at RAADFest 2017

-Stressed, toxic, zombie cells seen for 1st time in Alzheimer's

-Tau protein aggregation is associated with cellular senescence in the brain

-Quercetin and Tocotrienols - 500-800mg Quercetin and 150mg tocotrienols per day for 3 months -New study on whether NAD is absorbed into cell via IV

Episode Sponsors:

-Kion Aminos Whether you’re looking to stimulate faster muscle growth, recover more rapidly from exercise, become more resistant to fatigue during a grueling workout, or just benefit from additional amino acids in their most absorbable form to support aging or a vegan, vegetarian, or ketosis diet, Kion Aminos essential amino acids has you covered.

-Gluten Guardian "How to eat gluten and get away with it..." Get 10% off the already discounted price when you use my link!

-Thrive Market Makes healthy living easy and affordable at 25-50% off traditional retail prices. Use my link and get an additional $60 off your order.

-Gainswave The revolutionary bedroom biohack for guys who want optimal sexual performance.

Do you have questions, thoughts or feedback for Tom, Mark or me? Leave your comments below and one of us will reply!

See omnystudio.com/listener for privacy information.

Jaksot(1746)

Anti-Aging Secrets Of The World's Longest-Lived Woman, The Top Longevity "Drugs", Fat Loss & Muscle Gain Tips & Much More! Q&A 494

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Full Show Notes: https://bengreenfieldlife.com/494 In this episode, I dig into the fascinating story of the world’s oldest woman—a vibrant supercentenarian from Spain who made it to 117 years old. I break down what researchers discovered about her genes, lifestyle, and daily habits (you might be surprised by some of the things she ate and didn’t do!). I also get nerdy about the newest longevity drugs and supplements—like curcumin, spermidine, taurine, and a few others you might not expect—and explain which ones actually work, according to the science in mammals. Plus, I share some updates from my own life, like the weirdly exciting health setting I just found on my new iPhone, and spill the beans on why I microdose alcohol (and sometimes other things) instead of going on a bender. If you’re curious about muscle gain (do you really need to be in a calorie surplus?), soft-shell vs hardshell hyperbaric chambers, or how certain supplements might actually help you live longer, you’re in the right place. There’s a lot of info coming your way, and I’ve tried to translate all the geeky science into practical tips for you to use. Episode Sponsors: Health Lighting: If you want to see and feel the difference better light can make in your life, give Chromalux® full spectrum light bulbs a try. Go to healthlighting.com and use code Ben10 at checkout to save 10% off your order. Sunlighten: Sunlighten's patented infrared sauna technology delivers the highest quality near, mid, and far infrared wavelengths to reduce inflammation, boost mitochondrial function, enhance detox pathways, and optimize recovery—backed by 25+ years of clinically proven, non-toxic innovation. Save up to $1,400 at Sunlighten.com/BEN with code BEN. IM8: Ditch the cabinet full of supplements—IM8 packs 92 powerhouse ingredients into one delicious scoop for all-day energy, gut health, and cellular support. Go to IM8Health.com and use code BEN for an exclusive gift—fuel your body the right way! Gameday Men’s Health: Gameday Men's Health offers science-backed, physician-led men's health optimization with personalized protocols for testosterone, peptide therapy, ED treatment, and more—helping you perform at your best whether you're training hard or keeping up with life. Visit gamedaymenshealth.com/bengreenfield for a free testosterone test and consultation at a clinic near you. LMNT: Everyone needs electrolytes, especially those on low-carb diets, who practice intermittent or extended fasting, are physically active, or sweat a lot. Go to DrinkLMNT.com/BenGreenfield to get a free sample pack with your purchase!See omnystudio.com/listener for privacy information.

30 Loka 202538min

Women — You Need To Hear THIS! Testosterone & Steroids For a Better Body, How To Have *Mind-Blowing,* Juicy Sex (Throughout Menopause and Beyond!) & Much More With Dr. Amie Hornaman (Best of LIFE Network's Experts!)

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25 Loka 202551min

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18 Loka 202552min

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11 Loka 20251h 14min

A Fascinating Fireside Chat with Actor Luke Cook: Cyclical Keto, Ketones, Cold Plunges, Nootropics, Peptides & Living VITAL to the End!

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Can a Cultured Mushroom Extract *REALLY* Shrink Tumors, Clear HPV & Supercharge Immunity?, with Meagan Lindquist

Can a Cultured Mushroom Extract *REALLY* Shrink Tumors, Clear HPV & Supercharge Immunity?, with Meagan Lindquist

In this episode with Meagan Lindquist, you’ll discover the world of AHCC, a cultured mushroom extract with a remarkable range of health benefits. We explore its origins, patented culturing process in Japan, and what makes AHCC uniquely bioavailable compared to other mushroom supplements. Meagan shares her health journey, her experiences supporting patients, and her passion for spreading awareness about AHCC’s research-backed potential—from cancer and HPV to Lyme disease and overall immune function. The conversation highlights AHCC’s role as an immunomodulator, antioxidant, and anti-inflammatory compound, reviewing studies that demonstrate its benefits for general immune support and as complementary therapy for serious conditions, such as cancer and chronic infections. Practical topics include supplement quality, dosing, and how to find credible sources. By the end, you’ll have insights and actionable information to evaluate AHCC as part of a thoughtful, science-driven approach to immune optimization and integrative health. Meagan (Mimi) Lindquist (@mimi_themedicin) is the co-founder of The Medicin, alongside her husband Chase. Together, they provide high-quality mushroom products to the world. With her background as a clinical dental hygienist, nutrition guide, and AHCC educator, she has been helping others prevent disease for over 12 years. Now, Mimi is dedicated to sharing the benefits of Immune Intel AHCC, a mushroom product unlike any other, to as many people as possible. She hosts monthly live calls with Dr. Nathan Riley for women trying to clear HPV naturally using AHCC. In her words, it is her "life's passion to spread the word about how powerful it is." Full show notes: bengreenfieldlife.com/ahccpodcast Episode Sponsors: Organifi Shilajit Gummies: Harness the ancient power of pure Himalayan shilajit anytime you want with these convenient and tasty gummies. Get them now for 20% off at organifi.com/Ben. BlockBlueLight: BlockBlueLight BioLights are the only lights extensively tested and recommended by building biologist Brian Hoyer as truly flicker-free, ultra-low EMF, and circadian-friendly, with three modes (day, evening, night) that support natural rhythms and optimize sleep quality. Get 10% off your first order at blockbluelight.com/Ben (discount autoapplied at checkout). Fatty15: Fatty15 is on a mission to optimize your C15:0 levels and help you live healthier, longer. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/BEN and using code BEN at checkout. LVLUP Health: I trust and recommend LVLUP Health for your peptide needs as they third-party test every single batch of their peptides to ensure you’re getting exactly what you pay for and the results you’re after! Head over to bengreenfieldlife.com/lvluphealth and use code BEN15 for a special discount on their game-changing range of products. BiOptimizers Magnesium Breakthrough: The 7 essential forms of magnesium included in this full spectrum serving help you relax, unwind, and turn off your active brain after a long and stressful day so you can rest peacefully and wake up feeling refreshed, vibrant, and alert. Go to bioptimizers.com/ben and use code ben15 for 15% off any order.See omnystudio.com/listener for privacy information.

4 Loka 202552min

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