Beyond 23&Me: A Deep Dive Into Ben Greenfield's Personal DNA Results (& How To Get Your Own Genes Interpreted).
Boundless Life13 Kesä 2019

Beyond 23&Me: A Deep Dive Into Ben Greenfield's Personal DNA Results (& How To Get Your Own Genes Interpreted).

I'm constantly blown away by the amount of genetic data and actionable information one can garner from a simple bit of saliva.

In today's episode, you're going to get an insider glimpse into how to go way beyond something as simple as 23AndMe or Ancestry and instead learn how to get truly useful health information that you can use to enhance health, performance, sleep, gut function, neurotransmitters and cognition and much more.

My guest on this podcast, Dr. Mansoor Mohammed, has an extremely impressive background in the field of genetics.

His credentials include:

-BSc. Specialized Honours in Molecular Genetics | University of Guelph | Guelph -Doctor of Philosophy with Distinction in Molecular Genetics & Immunology | University of Guelph | Guelph -Postdoctoral Clinical Cytogenetics Fellowship | University of California | Los Angeles -Postdoctoral Clinical Cytogenetics Fellowship | Baylor College of Medicine | Houston

Dr. Mansoor is now the President and CSO of The DNA Company, a leading and innovative provider of comprehensive Functional Genomics testing and consulting and an industry first: individually customized supplements based on your genetics. He is widely regarded as a pioneer in medical genomics and has been the recipient of multiple academic and industry awards. He is the holder of several patents in the general fields of molecular diagnostics and genomics research and is one of the most sought-after national and international conference speakers in the genre of personalized medicine.

Prior to his role at The DNA Company, Dr. Mansoor was:

- Founder and President of ManaGene (2010-2018)

- CEO of Combimatrix (Nasdaq traded leader in diagnostic genomic microarrays) (2006-2010)

- Director of Genomics at Quest Diagnostics (The world’s largest reference laboratory with a market capitalization of over $10 billion US) (2003-2006)

- Director of Research and Development at Spectral Genomics (one of the industry’s first commercial genomic microarray developers spun out of Baylor College of Medicine under Dr. Mansoor’s scientific leadership)

Dr. Mansoor maintains an active clinical practice as a genomics consultant to some of the leading executive health clinics in Canada and abroad.

During our discussion, you'll discover: -What makes each DNA test different and how to choose what's right for you...9:30
  • Consider the various elements of genetic testing:
    • SNPs (pronounce "snips"; single nucleotide polymorphisms)
    • Copy number variation (CNV)
    • INDEL (insertion/deletion polymorphism)
  • Understand how the various labs go about testing the elements
  • Humans have two identical copies of the DNA code (from each parent)
  • When testing for SNPs, the genetic paragraph is "read" and looks for variations between the two
  • The more paragraphs you try to query simultaneously, the greater risk of error (false negatives/positives)
  • Characteristics of a proper DNA test:
    • Concern is for the physical manifestation of the genes, not the genes themselves
    • Cellular function is key indicator
    • Identify the genes that influence the desired outcome
    • Pinpoint the specific DNA to test vs. "shotgun" approach
    • Avoid drawing data for data's sake
-A review of Ben's DNA test and how they compare to his two sons...25:00
  • Two different reports: Genome Pulse Report and Hormone Pulse Report (looking at the GPR)
  • Vascular function
    • Cells that line the vascular system receive the most wear and tear
    • 9P21 markers (not genes) are correlated with the lining of the blood vessels; "the heart of the human genome"
    • A alleles and G alleles
    • The more G alleles you have, the less resilient is the endothelial lining
    • Increase good quality vegetable matter
    • People with multiple G alleles benefit less from vegetable matter (like red wine) than those with none
    • Smokers are more likely to die of vascular disease than lung disease
    • Glutathione S-Transferase (GST) pathway is one of the key pathways in the body
    • Glutathionization: the cellular process that neutralizes toxins in the body
  • What happens when someone doesn't have 2 copies of a gene...
    • You sometimes have genes you didn't inherit from either parent
    • Talking about SNPs in the gene is irrelevant;
    • As is epigenetics (alter the expression of the genes, not the genes itself)
  • 3 vitally important GST genes:
    • Theta 1,
    • Pai 1,
    • Nu1
  • Should a person only have 1 copy of a gene, they will produce 50% less than someone with 2 copies
  • Ben Greenfield has 1 copy of the GSTT1 gene (as does 60% of the population)
    • Important to not exceed a healthy toxicity threshold
  • Ben Greenfield does not have the GSTM1 gene at all
    • Useless to discuss SNPs for that gene
    • The M1 gene is a backup: it can be lost with less consequence than other genes (such as the T1)
  • What this means is that Ben Greenfield has low to average glutathione detox capacity
    • Must be more cognizant of diet, environment, etc.
  • Ben's two boys are missing the GSTT1 gene completely
-Personalizing diet and/or supplements based on DNA test results...57:25
  • Youtrients [link]
  • Nothing compares to an optimal diet (eating whole foods)
  • Customized based on dietary limitations (lactose intolerance)
  • Ethnic and geographic factors, as well as the environment during weaning, affect how to interpret test results
  • Elites of Victorian era England adjusted their lifestyle (living in Scottish highlands in the autumn months)
  • Reduce, not promote, supplementation, to where only necessary
  • Our bodies are not designed to accommodate many of the supplements on the market
  • "Is there a cellular function that is dysfunctional?" Then address that through supplementation
  • More is not always better when it comes to genetics
  • 3 disparate aspects of cellular function:
    • Endothelial quality
    • Detox capacity
    • Insulin productivity and function in response to diet
-Differences between the hormone pulse report and the genome pulse report...1:18:25
  • BDNF (brain-derived neurotropic factor) is one of the most important genes in our body
  • First thing looking at: How does the body (male or female) convert progesterones into androgens, into estrogens
  • t-intersection (4 points):
    • How efficiently converting progesterone into androgens
  • 3 things happen when you make testosterone:
    • Use it
    • Convert some of it into DHT
    • Metabolize (glucuronidation)
  • Ben has the perfect balance of the t-intersection
  • Ben's boys are identical, except have a higher predisposed conversion of testosterone into estrogen
-About the ACTN3 gene and its relation to exercise types...1:28:50 -And much more... Resources from this episode:

- Click here for testing with Youtrients through the TheDNACompany. They offer their complete functional genomics test package for $399 USD (that’s a savings of $50 from retail price), and your test package includes both Hormone and Genome Pulse panel tests as well as a clinical report for each panel, along with full access to their webinar series, which introduces the science and interpretation of your genomic results with regards to key biological systems and processes. Click here for that special offer from YouTrients for Ben Greenfield listeners.

- Ben's Hormone Pulse results from TheDNA Company [pdf-embedder url="/wp-content/uploads/2019/06/Ben-Greenfield-HORMONE-PULSE-REPORT.pdf" title="Ben Greenfield HORMONE PULSE REPORT"]

- Ben's Genome Pulse results from TheDNA Company [pdf-embedder url="/wp-content/uploads/2019/06/Ben-Greenfield-GENOME-PULSE-REPORT.pdf" title="Ben Greenfield GENOME PULSE REPORT"]

Episode sponsors:

-Kion: My personal playground for new supplement formulations. Ben Greenfield Fitness listeners receive a 10% discount off your entire order when you use discount code: BGF10.

-Trusii: Contains a host of anti-inflammatory, anti-obesity, and anti-allergy benefits. For this reason, I have decided to now make consumption of hydrogen-rich water an important part of my daily nutritional routine...and I highly recommend it! Enter code: BEN at checkout and get 30% off your order!

-Halo Sport: Halo Sport revolutionized physical training by being the first-ever product that can increase your neuroplasticity by putting your brain into a state that neuroscientists called hyperlearning. The fully upgraded Halo Sport 2 was just announced and it’s pre-selling for just $279 (less than half the price of the first model) when you use code: GREENFIELD.

-Birdwell Beach Britches: Quality is our Gimmick isn’t just our slogan, it’s a commitment we honor with every stitch we sew. 100% money back guarantee. Get 10% off your order, PLUS free shipping on any order over $99 when you use discount code: BENG.

Do you have questions, thoughts or feedback for Dr. Mansoor or me? Leave your comments below and one of us will reply!

See omnystudio.com/listener for privacy information.

Jaksot(1746)

Vaccines?! Between a Shot & a Hard Place: Are Childhood Vaccines SAFE, How Many Do Kids Really Need & What Parents Should Ask, with Dr. Joel Warsh

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20 Syys 202559min

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18 Syys 20251h 6min

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Low-Carb Vs. High-Carb Battle — What's BETTER For Your Health & Metabolism: Fats or Sugar? with Dr. Eric Westman and Jay Feldman

Low-Carb Vs. High-Carb Battle — What's BETTER For Your Health & Metabolism: Fats or Sugar? with Dr. Eric Westman and Jay Feldman

Jay Feldman is a health coach, independent health researcher, and the host of The Energy Balance Podcast. With degrees in neuroscience and exercise physiology from the University of Miami, he chose not to pursue medical school after realizing conventional medicine often fails to address the root causes of common health issues. After exploring both conventional and alternative paradigms and experimenting with diets from vegetarian to keto, Jay discovered that cellular energy is the foundation of health. He now uses a bioenergetic approach to help people worldwide overcome symptoms of low energy, including chronic hunger, poor sleep, and stubborn weight gain. Dr. Eric Westman is an Associate Professor of Medicine at Duke University. He is board-certified in Obesity Medicine and Internal Medicine, and founded the Duke Keto Medicine Clinic with Dr. William S. Yancy Jr. in 2006 after 8 years of clinical research regarding low-carbohydrate ketogenic diets. A past president and master fellow of the Obesity Medicine Association and fellow of The Obesity Society, Dr. Westman co-authored The New Atkins for a New You, Cholesterol Clarity, and Keto Clarity, and co-founded Adapt Your Life, a low-carb education and product company. Full show notes: bengreenfieldlife.com/lowhighcarb Episode Sponsors: Hiya: Give your kids the full-body nourishment they need to grow into healthy adults. I’ve secured a special deal with Hiya on their best-selling children's vitamin—get 50% off your first order today! To claim this deal, you must go to hiyahealth.com/BEN (it is not available on their regular website). Health Lighting: If you want to see and feel the difference better light can make in your life, give Chromalux® full spectrum light bulbs a try. Go to healthlighting.com and use code Ben10 at checkout to save 10% off your order. Organifi: Get the restful sleep you need with the most soothing ingredients! Organifi is a delicious superfood tea with powerful superfoods and mushrooms to help you sleep and recover so you can wake up refreshed and energized. Go to Organifi.com/Ben for 20% off your order. Prolon: Prolon's 5-Day Fasting Nutrition Program is scientifically tested and patented to nourish your body while keeping it in a physiological fasted state. Right now, you can save 15% on your 5-day nutrition program when you go to prolonlife.com/GREENFIELD. Pique: Pique Teas is where plants and science intersect to produce teas and supplements of unrivaled efficacy, purity, and convenience. Go to Piquelife.com/Ben to get 20% off for life, plus a free starter kit with a rechargeable frother and glass beaker to elevate your ritual. Seatopia: Seatopia delivers lab-tested, sushi-grade seafood that’s verified to be mercury-safe and free from detectable microplastics. Frozen at peak freshness, you'll receive the benefits of super nutrients like EPA, DHA, selenium, zinc, and vitamin D. Right now, you can save 15% on your first box and get a FREE 1:1 chef-led cooking class to kick-start your journey to cooking gourmet seafood at home by going to seatopia.fish/ben or by using code BEN at checkout.See omnystudio.com/listener for privacy information.

11 Syys 20251h 6min

Could This “Bible Secret” Be The Cure For Cancer? The WISEST Meal In The World, Pork & Shellfish *Confusion* & Much More With Jordan Rubin

Could This “Bible Secret” Be The Cure For Cancer? The WISEST Meal In The World, Pork & Shellfish *Confusion* & Much More With Jordan Rubin

In this episode with repeat guest Jordan Rubin, you’ll uncover a holistic plan for building strength, health, and longevity from one of the world’s most recognized natural health experts. Jordan shares how his family tradition of reciting Psalm 91 and insights from his new book, The Biblio Diet, reveal timeless biblical wisdom for vibrant living. He also highlights his groundbreaking research on “healing leaves” from fruit trees—their potential to fight cancer, balance blood sugar, reduce inflammation, and support longevity—and how to turn them into a daily healing tea. Jordan Rubin is the founder of Garden of Life, Beyond Organic, and Ancient Nutrition, and the New York Times bestselling author of The Maker’s Diet and over 30 other titles, including The Biblio Diet. An eco-entrepreneur and global lecturer, he has shared his message of natural health worldwide, formulated nearly 1,000 bestselling supplements and functional foods, and operates Regenerative Organic Certified farms in Missouri and Tennessee. Full show notes: https://bengreenfieldlife.com/biblio Episode Sponsors: MASA Chips: Introducing the best guilt-free snack on the market: classic, seed oil free tortilla chips with only 3 natural ingredients. Go to masachips.com/greenfield and get 25% off your first order! Quantum Upgrade: Recent research has revealed that the Quantum Upgrade was able to increase ATP production by a jaw-dropping 20–25% in human cells. Unlock a 15-day free trial with the code BEN15 at quantumupgrade.io. Ketone-IQ: Ketone-IQ delivers science-backed performance fuel that increases power output by 19%, reduces fatigue by 10%, and naturally boosts EPO production for better oxygen delivery—trusted by elite athletes like Jon Jones and Olympic champions. Save 30% on your subscription plus get a free gift with your second shipment at Ketone.com/BENG. Fatty15: Fatty15 is on a mission to optimize your C15:0 levels and help you live healthier, longer. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/BEN and using code BEN at checkout. LVLUP Health: I trust and recommend LVLUP Health for your peptide needs as they third-party test every single batch of their peptides to ensure you’re getting exactly what you pay for and the results you’re after! Head over to lvluphealth.com/BGL and use code BEN15 for a special discount on their game-changing range of products. ZBiotics Pre-Alcohol Probiotic: The world's first genetically engineered probiotic that helps break down the toxic byproduct of alcohol, Zbiotics Pre-Alcohol allows you to enjoy your night out and feel great the next day. Order with the confidence of a 100% money-back guarantee and 15% off your first order at zbiotics.com/BEN15.See omnystudio.com/listener for privacy information.

6 Syys 20251h 6min

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