
This Is How the AI Bubble Could Burst
This year, American tech companies will spend $300 billion to $400 billion on artificial intelligence, which is in nominal dollars more than any group of companies have ever spent to do anything. Notably, these companies are not remotely close to earning $400 billion on artificial intelligence. That's why you’re starting to hear some people wonder if the AI build-out is turning into the mother of all economic bubbles. The prospect of an AI bubble should scare us. Roughly half of last quarter's GDP growth came from infrastructure spending on AI, and more than half of stock market appreciation in the last few years has come from companies associated with AI. If the AI spending project blows up in the next few years, as our next guest says it might, the implications for technology, the economy, and politics would be immense. Paul Kedrosky is an investor and writer. Today we talk about the AI capex boom: how it works, who’s financing it, how its financing works. We put the AI build-out in historical context. And then we spend a great deal of time walking through what could go wrong and when it might go wrong. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Paul Kedrosky Producer: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices
23 Syys 202559min

The Jimmy Kimmel Saga and America's Free-Speech Crisis
Matt Belloni, the host of the Town podcast and the author of Puck’s 'What I’m Hearing' newsletter, joins the show to talk about Jimmy Kimmel's punishment, what happened behind the scenes at ABC and Disney, Bob Iger's legacy, and what this means at a moment when media companies are bending the knee to the Trump administration, which is clearly using its position to punish free speech despite rising to power by promising to do the opposite. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Matt Belloni Producer: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices
19 Syys 202540min

If GLP-1 Drugs Are Good for Everything, Should We All Be on Them?
To read more of Derek's reporting on GLP-1 drugs, you can subscribe to his Substack here. GLP-1 drugs like Ozempic and Zepbound don't just help with Type 2 diabetes and weight loss. They seem to curb alcohol, cocaine, and tobacco use among addicts. In some studies, they prevent strokes, heart attacks, chronic kidney disease, sleep apnea, and Parkinson's disease. They’re associated with a lower risk of several cancers, including pancreatic cancer and multiple myeloma. Arthritic patients on the drugs experienced relief from knee pain that was “on par with opioid drugs.” A small study found that they reduce migraine headaches by 50 percent. And emerging research suggests they might even slow the rate of memory loss among people diagnosed with Alzheimer’s. Is all of this real? And if it’s real, how is one drug doing so many different things? And if it is doing all those things, why shouldn’t we be developing versions of the drug for just about everyone? Today we have two guests: David D’Alessio, chief of endocrinology and metabolism at the Duke University School of Medicine; and Randy Seeley, a professor of surgery, internal medicine, and nutritional sciences at the University of Michigan. We talk about how these drugs work—why they seem to do everything—and how our understanding of them could make them better, more effective, more broadly useful. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guests: David D’Alessio and Randy Seeley Producer: Devon Baroldi Disclosure: Dr. Seeley has received research support from several pharmaceutical companies, including Eli Lilly, Diasome, and Amgen. Learn more about your ad choices. Visit podcastchoices.com/adchoices
16 Syys 202554min

Charlie Kirk's Killing and America's Age of "Salad-Bar Extremism"
In the past few years, we have witnessed a frightening spiral of political violence. We’ve seen the killing of Charlie Kirk; the killing of Brian Thompson, the health insurance executive; the assassination of a Minnesota House Speaker and her husband; the shooting of a Minnesota state senator and his wife; several attempted assassinations of Donald Trump; an attack on Nancy Pelosi’s home and husband; a plot to kidnap the governor of Michigan, Gretchen Whitmer; and calls to lynch Vice President Mike Pence on January 6. As The Atlantic’s Adrienne LaFrance writes, this is looking to be "an age of assassinations." LaFrance, the executive editor of The Atlantic, has written tens of thousands of words, including cover stories for the magazine, on the history of political violence in the U.S. Today, we talk about media coverage of political violence before getting to the hardest question: How can America survive a period of mass delusion, deep division, and political violence without seeing the permanent dissolution of the ties that bind us? If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Adrienne LaFrance Producer: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices
12 Syys 202552min

America in the Age of Diagnosis
America is sicker than ever. That’s what the data says, anyway. Psychological and psychiatric diagnoses have soared. Between the 1990s and the mid-2000s, bipolar disorder among American youth grew by a factor of 40, while the number of children diagnosed with ADHD increased by a factor of 7. Rates of PTSD, anxiety, and depression have soared, too. Perhaps in previous decades doctors missed millions of cases of illness that we’re now catching. Or perhaps, as the New York Times writer David Wallace Wells has written, “we are not getting sicker—we are attributing more to sickness.” We used to be merely forgetful. Now we have ADHD. We used to lack motivation. Now we’re depressed. We used to be introverted. Now we experience social anxiety. Today’s guest is Suzanne O’Sullivan, a neurologist and the author of 'The Age of Diagnosis: How Our Obsession with Medical Labels Is Making Us Sicker'. O’Sullivan argues that too many doctors today are pathologizing common symptoms in a way that’s changing the experience of the body for the worse. When doctors turn healthy people into patients, it’s not always clear if they’re reducing the risk of future disease or introducing anxiety and potentially harmful treatments to a patient who's basically fine. Rather than see the age of diagnosis as something all good or all bad—a mitzvah or a disease—I want to see it as a social phenomenon, something that is good and bad and all around us. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Suzanne O’Sullivan Producer: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices
9 Syys 202557min

Trumponomics Explained, Part 2: The Enshittification of American Power
In the second of our two-episode series on Donald Trump, economics, and power, we talk to Henry Farrell, a professor of political science at Johns Hopkins. Farrell has written extensively on how the United States has in the last few years weaponized its economic power to force other countries to do its bidding, through sanctions or the freezing of bank accounts. Today, we consider the many ways that Trump has weaponized the office of the presidency against American interests and how his authoritarian style matches up against China as both countries race toward superintelligence. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Henry Farrell Producer: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices
5 Syys 202552min

What Is Trumponomics? Part 1: How Donald Trump Is Breaking American Capitalism
Today is the first of two interviews this week trying to answer this question: What is Trumponomics? From the 1980s to the 2010s, it was generally assumed that Republicans and Democrats had settled differences in economic policy. Republicans wanted lower taxes and less spending on welfare. Democrats wanted higher taxes and more social spending. Reality didn’t always conform to those differences. George H.W. Bush famously raised some taxes, and Bill Clinton famously reduced some welfare spending. But generally speaking, the socialists voted for Democrats and the corporate libertarians and free-market folks found their home in the GOP. What’s interesting about Trump's theory of power and economics is that he doesn’t just scramble this divide. He obliterates it. Some of Trump’s measures are so classically Republican, you could imagine the ghost of Ronald Reagan signing off on them. After all, his signature legislative accomplishment in both terms are two huge corporate income tax cuts. But when Trump announced that the government was taking a stake in Intel, Bernie Sanders cheered the news and Gavin Newsom called him a socialist. Trump has single-handedly instituted the biggest tariffs in 100 years—tariffs that are so unusual and extralegal that a federal court just ruled that most of them are, in fact, against the law. He’s waging war on the Federal Reserve, grabbing at an institution that has historically enjoyed independence when it comes to setting interest rates and managing monetary policy. Trumponomics is capitalist and socialist; it’s obsessed with defeating China and also obsessive about copying China; it’s sometimes focused on keeping America from getting ripped off and sometimes focused on issues so personal they have nothing to do with the national interest at all. Today’s guest is Greg Ip, the chief economics commentator at The Wall Street Journal. According to Greg, the best way to see clearly what Trump is up to is to see his economic policy as what he calls “state capitalism.” If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Greg Ip Producer: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices
3 Syys 202549min

The Healthiest "Super-Agers" Have One Thing in Common, According to a 25-Year Study
Memory is the glue of life. Without it, our focus softens, our experience of the world blurs, and our identities melt away. But as people age, their memory declines. Many billions of dollars have been spent to understand the biological basis of dementia and to devise a cure. In most cases, they have failed spectacularly. But what if, rather than study the brains of people with advanced memory loss, we instead studied the brains of people with the opposite condition: extraordinary memory and brain health in old age? For the past few decades, Sandra Weintraub, a scientist at Northwestern University, has been part of a team studying the brains of "super-agers," people 80 and older who have the memory ability of people in their 50s. In a new paper published this year to considerable fanfare, she found that super-agers didn't have much in common. They didn't share a diet, or an exercise regimen, or a set of maladies or medications. One thing, however, united them: their social relationships. Today's guest is Sandra Weintraub. We talk about the science of memory and the brain and the protective benefit of social connection for our minds and ourselves. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Dr. Sandra Weintraub Producer: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices
27 Elo 202541min






















