The Truth About Ketamine: Depression Cure, Health Fad, or Placebo?

The Truth About Ketamine: Depression Cure, Health Fad, or Placebo?

One week ago, Matthew Perry’s autopsy report came back, finding that the ‘Friends’ actor died from the acute effects of ketamine overdose. His death has sharpened focus on the popular and controversial drug. Ketamine has been hailed as a miracle cure for depression and anxiety, criticized as a VC-fueled fad, and investigated as a placebo. But what is ketamine, what is its history, what do we know about how and why it works, and how could it help hundreds of millions of people with depression and anxiety? Today’s guest is Boris Heifets. He is an assistant professor of anesthesiology at Stanford University and the author of a much talked about and utterly fascinating study on ketamine that came up with a brilliant way to test the effects of ketamine. The study's surprising results raise big questions about not only ketamine, but the curative power of belief. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guest: Boris Heifets Producer: Devon Baroldi Learn more about your ad choices. Visit podcastchoices.com/adchoices

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How Metrics Make Us Miserable

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The Future of GLP-1 Drugs and AI Medicine, With Eli Lilly CEO David Ricks

The Future of GLP-1 Drugs and AI Medicine, With Eli Lilly CEO David Ricks

The GLP-1 drug revolution has taken the medicine world by storm. I’ve done several episodes on the science of GLP-1s. But we’ve never done an episode like this before, where we talk to one of the most...

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The Supreme Court Strikes Down Trump’s Tariffs. Now What?

The Supreme Court Strikes Down Trump’s Tariffs. Now What?

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The Media Theory That Explains “99% of Everything”

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In the mid-20th century, a group of media and communications scholars proposed that the shift from spoken to written language—from orality to literacy—transformed our politics, our media, our social r...

17 Helmi 1h 3min

"America Isn’t Ready for What AI Will Do to Jobs"

"America Isn’t Ready for What AI Will Do to Jobs"

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The Meltdown at The Washington Post—and the Crisis in News

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Hello! I’m back from paternity leave just in time to talk about the biggest media earthquake of the year (so far): the Washington Post meltdown. For decades, the Post was a journalistic gem with super...

11 Helmi 1h 11min

Plain English BEST OF: What’s the Matter With America’s Food?

Plain English BEST OF: What’s the Matter With America’s Food?

Throughout December and January, we’ve been re-airing some of our favorite episodes of the past year and beyond, and today's episode marks the end of our "best of" series for this year! This list incl...

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Plain English BEST OF: This Is How the AI Bubble Could Burst

Plain English BEST OF: This Is How the AI Bubble Could Burst

Throughout December and January, we’re going to be re-airing some of our favorite episodes of the past year and beyond. This list includes interviews that really stuck with me and some others that you...

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