Neuromuscular Blocking Agents

Neuromuscular Blocking Agents

Author: Peter Bakes

Educational Pearls:

  • The Neuromuscular Junction (NMJ) is a neuronal synapse in skeletal muscle mediated by nicotinic acetylcholine receptors.
  • Paralytic agents, commonly used in the ED for intubation, include succinylcholine and rocuronium/vecuronium.
  • Succinylcholine is a depolarizing paralytic while rocuronium is a non-depolarizing agent.
  • A newly developed reversing agent, sugammadex, can be used to counter the effects of curonium based paralytics. This is especially helpful due to the long duration of action of rocuronium (45 minutes to 1 hour) as compared to succinylcholine (<15 minutes).

References: https://www.acep.org/Physician-Resources/Clinical/Thoracic-Respiratory/Rocuronium-vs--Succinylcholine--Which-Is-Best-/

Jaksot(1145)

Podcast 774: Maggots

Podcast 774: Maggots

Contributor: Chris Holmes, MD Educational Pearls: Maggots were discovered as a therapy to help wound healing in WWI, but this fell out of favor after the discovery of penicillin One study from Israel...

19 Huhti 20225min

Podcast 773: Atrial Fibrillation Medications

Podcast 773: Atrial Fibrillation Medications

Contributor: Aaron Lessen, MD Educational Pearls: Atrial fibrillation is an irregular heart rhythm that sometimes requires rate control in setting of rapid ventricular response (RVR) Calcium channel ...

18 Huhti 20223min

Podcast 772: Firearms in Suicidal Ideation

Podcast 772: Firearms in Suicidal Ideation

Contributor: Aaron Lessen, MD Educational Pearls: Firearms are a dangerous potential method of committing suicide Death occurs in about 5-15% of suicide attempts overall, but death in suicide attempt...

12 Huhti 20224min

Podcast 771: Intubation in Cardiac Arrest

Podcast 771: Intubation in Cardiac Arrest

Contributor: Don Stader, MD Educational Pearls: In a secondary analysis of the PART trial, the mortality effect of timing of airway management for patients in cardiac arrest was examined Study looked...

11 Huhti 20223min

Podcast 770: Xylazine

Podcast 770: Xylazine

Contributor: Don Stader, MD Educational Pearls: Xylazine, referred to as tranq dope colloquially, is an FDA approved animal tranquilizer that is circulating in the illicit drug markets of the northea...

5 Huhti 20223min

Podcast 769: Pressors After Cardiac Arrest

Podcast 769: Pressors After Cardiac Arrest

Contributor: Aaron Lessen, MD Educational Pearls: Hypotension after cardiac arrest often requires a vasopressor to improve blood pressure Recent observational study from France examined outcomes of p...

4 Huhti 20223min

Mental Health Monthly #11: De-escalation: Changing Confrontation to Collaboration

Mental Health Monthly #11: De-escalation: Changing Confrontation to Collaboration

Contributor: Dr. Kimberly Nordstrom De-escalation usually takes less time than physical and chemical restraints, which leads to decreased injury to staff members, better patient trust and increased p...

30 Maalis 202216min

Podcast 768: Takotsubo Cardiomyopathy

Podcast 768: Takotsubo Cardiomyopathy

Contributor: Peter Bakes, MD Educational Pearls: 3% of cases of acute coronary syndrome are due to Takotsubo Takotsubo cardiomyopathy or "broken heart syndrome" can occur with severe physiologic or ...

29 Maalis 20224min

Suosittua kategoriassa Tiede

tiedekulma-podcast
rss-mita-tulisi-tietaa
rss-poliisin-mieli
docemilia
radio-antro
utelias-mieli
rss-sosiopodi
ihanat-ipanat
mielipaivakirja
filocast-filosofian-perusteet
rss-bios-podcast
rss-laakaripodi
rss-radplus
rss-opeklubi