Podcast #261: Icatibant

Podcast #261: Icatibant

Author: Aaron Lessen, M.D.

Educational Pearls

  • Icatibant was introduced to treat ACE-inhibitor induced angioendema.
  • This type of angioedema is refractory to epinephrine and antihistamines, and is likely mediated by elevated bradykinin.(which is inactivated by ATII and ACE).
  • Icatibant initially was shown to reduce facial swelling and airway obstruction in the setting of ACE-I angioedema, but later, better-powered studies showed that it had no benefit compared to standard treatment.

References: Sinert R et al. Randomized Trial of Icatibant for Angiotensin-Converting Enzyme Inhibitor-Induced Upper Airway Angioedema. J Allergy Clin Immunol Pract 2017. PMID: 28552382

Jaksot(1146)

Podcast #383: Prehospital Tubes

Podcast #383: Prehospital Tubes

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Podcast #382: Shoulder Separations

Podcast #382: Shoulder Separations

Author: Ryan Circh, MD Educational Pearls: A "shoulder separation" is when the clavicle separates from the scapula - also referred to as an acromio-clavicular (AC) separation Diagnosis is clinic...

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Podcast #381: MRI... Burns?

Podcast #381: MRI... Burns?

Author: Sam Killian, MD Educational Pearls: MRI machines can generate enough heat from the radiofrequency to cause thermal burns Patients with EKG stickers, medication patches, clothing impregna...

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Podcast #380: Oxygen for the kill

Podcast #380: Oxygen for the kill

Author: Ryan Circh, MD Educational Pearls: Review of 25 randomized control trials encompassing 16,037 acutely ill hospitalized patients Patients given oxygen with saturations > 94% on room air wer...

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Podcast #379: Patient Perspectives of the Flu

Podcast #379: Patient Perspectives of the Flu

Author: Sam Killian, MD Educational Pearls: Patients may have certain fears or expectations about the flu based on hearsay and other less reliable sources Taking extra time explaining the risks ...

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Podcast #378: Is That a Brown Recluse Spider Bite?

Podcast #378: Is That a Brown Recluse Spider Bite?

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Podcast #377: Endocarditis

Podcast #377: Endocarditis

Author: Nick Tsipis, MD Educational Pearls: Persistent fever or positive blood cultures should raise suspicion for endocarditis Patients with recent dental procedures, recent cardiac surgeries a...

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Podcast #376: Alcohol Intoxication

Podcast #376: Alcohol Intoxication

Educational Pearls: Blood concentrations over 0.4 mg/dL is associated with respiratory depression and possible death in alcohol naive patients Alcohol overdose accounts to 2,200 deaths per year ...

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