Podcast #261: Icatibant

Podcast #261: Icatibant

Author: Aaron Lessen, M.D.

Educational Pearls

  • Icatibant was introduced to treat ACE-inhibitor induced angioendema.
  • This type of angioedema is refractory to epinephrine and antihistamines, and is likely mediated by elevated bradykinin.(which is inactivated by ATII and ACE).
  • Icatibant initially was shown to reduce facial swelling and airway obstruction in the setting of ACE-I angioedema, but later, better-powered studies showed that it had no benefit compared to standard treatment.

References: Sinert R et al. Randomized Trial of Icatibant for Angiotensin-Converting Enzyme Inhibitor-Induced Upper Airway Angioedema. J Allergy Clin Immunol Pract 2017. PMID: 28552382

Jaksot(1146)

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Podcast # 363:  Ketamine for Alcohol Withdrawal

Podcast # 363: Ketamine for Alcohol Withdrawal

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Podcast # 362: Giant Hogweed

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Podcast # 361: Vertiginous Dizziness

Podcast # 361: Vertiginous Dizziness

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Podcast # 360: Epidural Abscess Screening

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