Podcast #323: Calcium Channel Toxicity

Podcast #323: Calcium Channel Toxicity

Author: Jared Scott, M.D.

Educational Pearls:

  • Cardiac myocytes and vascular smooth muscle are dependent on an intracellular calcium influx for contraction. Pancreatic beta cells rely on calcium to release insulin.
  • Calcium channel blockers will decrease cardiac contractility and heart rate, but will also cause vascular smooth muscle relaxation with a subsequent decrease in systemic vascular resistance.
  • Resultant cardiac depression and hypotension.
  • Pancreatic beta cells also use calcium to release insulin, so calcium channel blockade can cause hyperglycemia.
  • Treatment for calcium channel toxicity include: fluid resuscitation, calcium gluconate, vasopressors, and high dose insulin.
  • Dosing for insulin therapy is usually 1-5 Units/kg/hr. Make sure to add dextrose!

References:

Boyer EW, Shannon M. (2001).Treatment of calcium-channel-blocker intoxication with insulin infusion. New England Journal of Medicine. 344:1721.

Proano L, Chiang WK, Wang RY. (1995).Calcium channel blocker overdose. American Journal of Emergency Medicine. 13:444.

St-Onge M, Dubé PA, Gosselin S, et al. (2014). Treatment for calcium channel blocker poisoning: a systematic review. Clinical Toxicology. 52:926.

Jaksot(1145)

Podcast #302: Flu

Podcast #302: Flu

Author: Jared Scott, M.D. Educational Pearls Flu is widespread throughout the US (through Jan 20th 2018). All age groups have seen surge in hospitalizations, but 65 + age group has seen the largest s...

7 Maalis 20183min

Podcast #301: Biliary Pathology

Podcast #301: Biliary Pathology

Author: Don Stader, M.D. Educational Pearls Common pathologies include cholecystitis, choledocholithiasis, and in concerningly ascending cholangitis. Cholecystitis is obstruction at the cystic duct l...

5 Maalis 20183min

Opioid Safety Summit: Admiral Winnefeld's Strategy to Wage War on the Opioid Epidemic

Opioid Safety Summit: Admiral Winnefeld's Strategy to Wage War on the Opioid Epidemic

Since the tragic overdose of his son, Admiral Winnefeld has developed an intriguing strategy on how to combat the Opioid Epidemic.

27 Helmi 20180s

Dreamland in Denver Part VI: "Dreamland"

Dreamland in Denver Part VI: "Dreamland"

Sam Quinones, American journalist and author of the critically acclaimed book, Dreamland: The True Tale of America's Opiate Epidemic, shares the story of how he discovered the truth about the Opiate E...

16 Helmi 201843min

Dreamland in Denver Part V: "Tales from a Harm Reductionist"

Dreamland in Denver Part V: "Tales from a Harm Reductionist"

Lisa Raville, executive director of The Harm Reduction Action Center in Denver, shares tales from her perspective as a Harm Reductionist.

16 Helmi 201810min

Dreamland in Denver Part IV: "Doing Harm: Medicine's Role in Creating the Opioid Crisis."

Dreamland in Denver Part IV: "Doing Harm: Medicine's Role in Creating the Opioid Crisis."

Emergency Medical Minute's very own Donald Stader, MD explains Medicine's contribution to the catastrophe that is the Opioid Epidemic.

16 Helmi 201819min

Dreamland in Denver Part III:  "Opioid Mythbusters: 10 Fallacies that Fueled the Opiate Crisis"

Dreamland in Denver Part III: "Opioid Mythbusters: 10 Fallacies that Fueled the Opiate Crisis"

Dr. Robert Valuck, director of the Colorado Consortium, presents 10 fallacies that have fueled the Opioid Epidemic.

16 Helmi 201819min

Dreamland in Denver Part II: "Why Calling it 'the Opioid Epidemic' Misses the Point

Dreamland in Denver Part II: "Why Calling it 'the Opioid Epidemic' Misses the Point

The Honorable Alby Zweig shares his impactful first-hand experience with addiction, recovery and triumph.

16 Helmi 20180s

Suosittua kategoriassa Tiede

tiedekulma-podcast
rss-mita-tulisi-tietaa
rss-poliisin-mieli
rss-duodecim-lehti
docemilia
filocast-filosofian-perusteet
rss-ammamafia
rss-luontopodi-samuel-glassar-tutkii-luonnon-ihmeita
rss-sosiopodi
utelias-mieli
radio-antro
rss-astetta-parempi-elama-podcast
rss-tiedetta-vai-tarinaa