Podcast # 470: Zofran and Pregnancy

Podcast # 470: Zofran and Pregnancy

Author: Jared Scott, MD

Educational Pearls:

  • Ondansetron (Zofran) is one of the latest drugs that has had concerns raised about side effects, particularly in pregnancy
  • 2018 study probed two birth defect databases to assess increases in 51 major birth defects with increased exposure to ondansetron
  • Only two of the 51 had even a modest increase, which is unclear in causation (cleft palate and renal agenesis)
  • When administering ondansetron (or any drug) to pregnant women, be able to discuss any potential risks for an informed decision by the patient

Editor's note: in this study, adjusted odds ratios for risk of birth defects from exposure to ondansetron were: cleft palate 1.6 (95% CI 1.1-2.3) and renal agenesis 1.8 (95% CI 1.1-3.0)

References

Parker SE, Van Bennekom C, Anderka M, Mitchell AA. Ondansetron for Treatment of Nausea and Vomiting of Pregnancy and the Risk of Specific Birth Defects. Obstet Gynecol. 2018 Aug;132(2):385-394. doi: 10.1097/AOG.0000000000002679. PubMed PMID: 29995744.

Summarized by Will Dewispelaere, MS3 | Edited by Erik Verzemnieks, MD



Tämä jakso on lisätty Podme-palveluun avoimen RSS-syötteen kautta eikä se ole Podmen omaa tuotantoa. Siksi jakso saattaa sisältää mainontaa.

Jaksot(1169)

Podcast 1014: Eating and Drinking on Shift

Podcast 1014: Eating and Drinking on Shift

Contributor; Aaron Lessen, MD Educational Pearls: A 2026 survey asked Canadian emergency medicine (EM) physicians about their eating and drinking habits while on shift. Among 527 respondents, 35%...

27 Heinä 2min

Podcast 1013: Thoracotomy Indications

Podcast 1013: Thoracotomy Indications

Contributor; Taylor Lynch, MD Educational Pearls: Thoracotomy  Thoracotomy is used in traumatic cardiac arrest to replace conventional CPR with direct access to the chest. Goals include identif...

20 Heinä 3min

Podcast 1012: Meth Sedation

Podcast 1012: Meth Sedation

Contributor: Aaron Lessen, MD Educational Pearls:    Agitated patients who are intoxicated with methamphetamine pose a unique challenge when selecting a sedative to counter their symptoms. Is there ...

13 Heinä 1min

Podcast 1011: Creepy Crawlies

Podcast 1011: Creepy Crawlies

Contributor: Meghan Hurley, MD Educational Pearls: What animal is the most lethal to humans?  Depending on how we define lethal, and animal, this answer is actually not straight forward.  Globall...

6 Heinä 7min

Podcast 1010: First Pass Intubation Success

Podcast 1010: First Pass Intubation Success

Contributor: Travis Barlock, MD Educational Pearls:   First-pass success is critical to limit complications from apnea, hypoxia, and airway trauma.  Complication rate for patients intubated on the f...

29 Kesä 3min

On the Streets- Zero to Rodeo

On the Streets- Zero to Rodeo

Dan Orbidan, OMS-II and Dr. Travis Barlock, MD discuss a real out of hospital call. This episode covers the implications of a pharmacologically abnormal patient presentation and the pre and post hospi...

22 Kesä 35min

Carepoint Journal Club- Neurology

Carepoint Journal Club- Neurology

Carepoint Journal Club is a quarterly series with discussions about a medical topic, brought to you by Carepoint's Emergency Physicians.

15 Kesä 36min

Podcast 1009: Prevention for Recurrent UTI

Podcast 1009: Prevention for Recurrent UTI

Contributor: Aaron Lessen, MD Educational Pearls:   UTIs are commonly seen in older women We often see them taking long-term prophylactic antibiotics because of common recurrence. Around 20-30% of...

8 Kesä 1min

Suosittua kategoriassa Tiede

tiedekulma-podcast
utelias-mieli
rss-mita-tulisi-tietaa
hippokrateen-vastaanotolla
rss-hereilla
mielipaivakirja
radio-antro
rss-poliisin-mieli
menologeja-tutkimusmatka-vaihdevuosiin
rss-laakaripodi
rss-astetta-parempi-elama-podcast
rss-totuuden-liepeilla
docemilia
filocast-filosofian-perusteet
rss-tiedetta-vai-tarinaa
rss-murremyytin-murtajat
rss-ylistys-elaimille