Podcast 529: Hemophilia

Podcast 529: Hemophilia

Contributor: Aaron Lessen, MD

Educational Pearls:

  • Hemophilia is characterized by bleeding (A /B) A is is 8, B (chrstmas, 9)
  • Hemophilia refers to a group of bleeding disorders caused by a deficiency in a certain clotting factor. The two most common are hemophilia A (caused by a lack of factor VIII), and B (caused by a lack of factor 9)
  • Most cases are inherited in an X-linked recessive manner. Therefore, males are the most commonly affected. However, spontaneous cases do occur in all sexes.
  • People with hemophilia can present to the ED with a variety of bleeding complications including hemarthrosis, intracranial hemorrhage, and GI bleeds.
  • Treatment is guided by the type of hemophilia and the degree of bleeding, with the most severe cases being treated with replacement of 100% of that person's deficient clotting factor.
  • Timely treatment improves outcomes, so consider empiric therapy in those with known hemophilia

References

Hemophilia A in the third millennium.Franchini M, Mannucci PM Blood Rev. 2013 Jul;27(4):179-84. Epub 2013 Jun 28.

Rheumatic manifestations of hematologic disorders.Aviña-Zubieta JA, Galindo-Rodriguez G, Lavalle C Curr Opin Rheumatol. 1998;10(1):86.

The molecular genetics of hemophilia: blood clotting factors VIII and IX.Lawn RM Cell. 1985;42(2):405.

Guidelines for the management of hemophilia.Srivastava A, Brewer AK, Mauser-Bunschoten EP, Key NS, Kitchen S, Llinas A, Ludlam CA, Mahlangu JN, Mulder K, Poon MC, Street A, Treatment Guidelines Working Group on Behalf of The World Federation Of Hemophilia Haemophilia. 2013 Jan;19(1):e1-47. Epub 2012 Jul 6.

Summarized by Will Dewispelaere, MS4 | Edited by Erik Verzemnieks, MD

Jaksot(1147)

Podcast # 416: Wide Complex Tachycardia

Podcast # 416: Wide Complex Tachycardia

Author: Aaron Lessen, MD Educational Pearls: Defined as QRS over 120 ms and rate over 120 Two major rhythms = Vetricular tachycardia (VT) or SVT with aberrancy Safest approach is to assume it is VT S...

12 Joulu 20183min

Podcast # 415: Myofascial Pain Syndrome & Fibromyalgia

Podcast # 415: Myofascial Pain Syndrome & Fibromyalgia

Author: Ryan Circh, MD Educational Pearls: Myofascial pain syndrome (MFPS) is typically unilateral with discrete points of palpable pain Often secondary to repeated use and poor posture. MFPS typical...

10 Joulu 20182min

Podcast # 414: Acute Limb Ischemia

Podcast # 414: Acute Limb Ischemia

Author: Dylan Luyten, MD Educational Pearls: Symptoms of acute limb ischemia are the 5 P's: Pulselessness, pain, pallor, paresthesias, and poikilothermia Sudden onset of non-traumatic extremity pai...

8 Joulu 20184min

Podcast # 413: Fascia Iliaca Block

Podcast # 413: Fascia Iliaca Block

Author: Katie Sprinkle, MD Educational Pearls: The fascia iliaca block is useful for hip and proximal femur fractures. Typically involves injecting 40-60 mL of diluted bupivacaine (0.25%) under the...

6 Joulu 20186min

Podcast #412: tPa Mission Creep

Podcast #412: tPa Mission Creep

Author: Aaron Lessen, MD Educational Pearls: Patients with "minor" strokes with NIHSS 0 to 5 can still end up having poor long-term outcomes Recent study compared use of alteplase vs. aspirin for th...

3 Joulu 20182min

Podcast #411: Mass Casualty Incident

Podcast #411: Mass Casualty Incident

Author: Dylan Luyten, MD Educational Pearls: Early recognition that the current situation is a mass casualty incident (MCI) is essential with establishing a sole provider/nurse to oversee Team memb...

30 Marras 20184min

Podcast #410: FAmbulance

Podcast #410: FAmbulance

Author: Aaron Lessen, MD Educational Pearls: Retrospective study looking at type of transportation and mortality outcomes for patients with penetrating trauma Mortality was 2.2 % for those brought in...

28 Marras 20182min

Podcast #409:  Acute CHF Second Liners

Podcast #409: Acute CHF Second Liners

Author: Nick Hatch, MD Educational Pearls:   Quick review on typical treatments for acute CHF: Nitrates are a mainstay to reduce preload Furosemide has fallen out of favor in regards to urgency but ...

26 Marras 20183min

Suosittua kategoriassa Tiede

rss-mita-tulisi-tietaa
rss-poliisin-mieli
utelias-mieli
tiedekulma-podcast
docemilia
rss-luontopodi-samuel-glassar-tutkii-luonnon-ihmeita
rss-duodecim-lehti
rss-tervetuloa-tervemenoa
rss-ylistys-elaimille
rss-tervetta-skeptisyytta